NCT05413083

Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis

Dynamic Assessment of Cardiac Function in Acutely Decompensated Cirrhosis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Clinical Hospital Colentina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This project aims to investigate cardiac function in patients with cirrhosis in the acute setting. Acute decompensation and acute-on-chronic liver failure are major events in the life of a patient as they herald disease progression and negative prognosis. Cardiocirculatory function will be assessed by serial assessments in patients admitted for acute decompensation of cirrhosis.

Detailed description

In this project we aim to investigate the dynamic role of cardiac function in the short-term evolution of patients with AD of cirrhosis through noninvasive and accessible tests and validate prognostic imaging and serum biomarkers. The main objectives are: 1. To describe changes and evolution of cardiac function in AD of cirrhosis 2. To investigate associations between echocardiographic parameters and serum biomarkers 3. To investigate the association between ACLF and cardiac dysfunction 4. To assess the short-term prognostic impact of cardiac function in AD and ACLF; 5. To evaluate the added predictive value of cardiac markers to current scores (CLIF-C).

Conditions

• Cirrhosis
• Acute Liver Failure
• Cardiomyopathies

Timeline

• Start date: 2022-06-06
• Primary completion: 2024-08-31
• Completion: 2024-10-31
• First posted: 2022-06-09
• Last updated: 2024-06-04

Locations

1 site across 1 country: Romania