NCT06893042

Clinical Study of Pediatric Acute Liver Failure

A Prospective Study on the Real Word of Acute Liver Failure in Children

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 7 (estimated)
• Sponsor: Fansen Zeng · Academic / Other
• Sex: All
• Age: 1 Minute – 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to understand the etiology, prognosis and influencing factors of acute liver failure in children, evaluate the predictive value of children's SOFA score, PELD score and LIU score for the short-term mortality rate of children's liver failure and the infection of children's acute liver failure; analyze the bleeding and kidney damage of children's acute liver failure, and evaluate the quality of life of children's acute liver failure.

Detailed description

PALF is a seriously life-threatening acute disease with a rapid onset, rapid progression and high mortality rate. Especially under the influence of multiple organ dysfunction syndrome (MODS) or other serious complications, clinical prognosis evaluation and treatment decision-making face great challenges.It aims to accurately evaluate the survival probability or liver transplantation needs of patients based on clinical data and biological indicators, and deeply reveal the impact of different factors on the prognosis of PALF from the perspective of etiology, treatment mode (such as mechanical ventilation and plasma replacement) and complications (such as MODS and its score), so as to provide a scientific basis for identifying high-risk groups, optimizing personalized treatment strategies and early diagnosis.

Conditions

• Acute Liver Failure

Timeline

• Start date: 2024-09-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-03-25
• Last updated: 2025-03-25

Locations

1 site across 1 country: China