Trials / Conditions / Tobacco Use Disorder

Tobacco Use Disorder

339 registered clinical trials studyying Tobacco Use Disorder — 35 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Chatbot for Online Support Groups to Treat Tobacco Addiction NCT06952725	University of California, Irvine	N/A
Not Yet Recruiting	Facilitation to Increase Tobacco Treatment NCT07455526	VA Office of Research and Development	N/A
Not Yet Recruiting	Varenicline for Smoking Reduction in Veterans Not Ready To Quit NCT06966362	VA Office of Research and Development	Phase 4
Not Yet Recruiting	Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily NCT07425119	Duke University	N/A
Not Yet Recruiting	Effects of Nicotine Dependence on Multidimensional Health Outcomes NCT07474623	Izmir Democracy University	N/A
Not Yet Recruiting	Quit-Smoking Study for Native Hawaiians NCT07075575	University of Hawaii	N/A
Recruiting	Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients NCT07466875	Chiao-Chiao Liao	N/A
Not Yet Recruiting	Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia NCT07198828	Gadjah Mada University	N/A
Not Yet Recruiting	Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study NCT07001371	Loma Linda University	N/A
Enrolling By Invitation	Engaging Pharmacists to Advance Tobacco Treatment Service Delivery NCT07501624	Medical University of South Carolina	N/A
Not Yet Recruiting	Accelerated dTMS Smoking Cessation NCT07292883	Waypoint Centre for Mental Health Care	Phase 2
Active Not Recruiting	Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients NCT07164404	Medical University of South Carolina	N/A
Recruiting	Contingency Management for Veteran Smokers Undergoing Major Elective Surgery NCT06678672	University of California, San Francisco	N/A
Unknown	Theta-burst Repetitive Transcranial Magnetic Stimulation (TBS) of the Right Inferior Frontal Gyrus for Treatme NCT05389670	University of Missouri-Columbia	N/A
Active Not Recruiting	Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 NCT06006143	Yale University	Phase 2
Completed	Family and Peer Influences on Nicotine Dependence in Medical Students of South Punjab NCT07123389	Nishtar Medical University	—
Recruiting	Cannabis-Tobacco Co-Use Treatment Study NCT06883162	Medical University of South Carolina	Phase 3
Recruiting	tDCS Plus Varenicline for Smoking Cessation NCT06798324	Centre for Addiction and Mental Health	Phase 4
Recruiting	E-cigarette Cessation in Adults Who Co-use Cannabis NCT06688539	Medical University of South Carolina	Phase 4
Recruiting	Smoking Cessation CM for Veterans With or at Risk for Cancer NCT06432985	VA Office of Research and Development	N/A
Recruiting	Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics NCT06624137	Yale University	—
Active Not Recruiting	A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder NCT06609902	Massachusetts General Hospital	N/A
Recruiting	Effectiveness of Smoking Cessation Education NCT06930547	Erzurum Technical University	N/A
Recruiting	Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity NCT06617312	University of California, Los Angeles	Phase 2
Recruiting	Beta-Adrenergic Modulation of Drug Cue Reactivity NCT05587361	University of Oklahoma	Phase 4
Recruiting	Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes NCT06614504	University of Vermont	Phase 2
Recruiting	Cannabidiol for Reducing Cigarette Use NCT06218056	University of California, Los Angeles	Phase 2
Completed	Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smok NCT07366294	Titin Andri Wihastuti	N/A
Recruiting	Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial NCT06534047	Centre for Addiction and Mental Health	Phase 4
Withdrawn	Emergency Department Management of Tobacco Use Disorder NCT06350175	West Virginia University	Phase 4
Recruiting	Young Adult Tobacco/Nicotine and Cannabis Co-use NCT06239350	Medical University of South Carolina	N/A
Active Not Recruiting	Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study NCT07192601	Florida International University	N/A
Recruiting	Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation NCT05726045	Central Institute of Mental Health, Mannheim	N/A
Not Yet Recruiting	Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism NCT05947162	Shenzhen Kangning Hospital	N/A
Recruiting	5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder NCT05452772	Johns Hopkins University	Phase 2
Recruiting	Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessatio NCT05723588	VA Office of Research and Development	Phase 2
Withdrawn	Equitable Smoking Relapse Prevention NCT05625685	Bryan W. Heckman	N/A
Enrolling By Invitation	Enhancing Equity in Smoke-free Housing NCT06042361	Harvard School of Public Health (HSPH)	N/A
Recruiting	Smoking Cessation Program for Adults With Type 2 Diabetes Mellitus (DiMe-SALUD2 Project) NCT05885659	University of Seville	N/A
Recruiting	Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation NCT05766553	Centre Hospitalier Henri Laborit	N/A
Withdrawn	Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans NCT05294263	VA Office of Research and Development	Phase 2
Active Not Recruiting	fMRI Study of the Neural Mechanism of rTMS in the Treatment of Nicotine Dependence NCT06762535	Tang-Du Hospital	N/A
Terminated	Tobacco Treatment Using EMDR (ToTEM) NCT05594810	IrisZorg	N/A
Completed	Cytisine for Smoking Cessation NCT05729243	Centre for Addiction and Mental Health	Phase 4
Unknown	TinCat LGBTQ+ Smoking Cessation Via Asynchronous Telehealth NCT05499364	University of Texas at Austin	N/A
Completed	QuitGuide for American Indians: Aims 2 & 3 NCT05447156	Masonic Cancer Center, University of Minnesota	N/A
Recruiting	Oral Cannabidiol for Tobacco Cessation NCT05445804	Johns Hopkins University	Phase 1
Unknown	Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations NCT05875194	University Hospital Tuebingen	N/A
Completed	Effects of Semaglutide on Nicotine Intake NCT05530577	University of North Carolina, Chapel Hill	Phase 2
Withdrawn	Adaptive Treatment Strategies for Improving Engagement With a Web-Based Smoking Intervention in Socially Anxio NCT04260776	Fred Hutchinson Cancer Center	Phase 1
Recruiting	Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula NCT06405074	Washington D.C. Veterans Affairs Medical Center	N/A
Completed	Reduced Nicotine Cigarette Purchasing Decisions NCT04999644	Johns Hopkins University	EARLY_Phase 1
Active Not Recruiting	A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers NCT05044546	M.D. Anderson Cancer Center	N/A
Completed	Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings NCT05030272	Wake Forest University Health Sciences	N/A
Completed	Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder NCT05049460	Gopalkumar Rakesh	N/A
Completed	A Bioequivalence Study of 21 Milligram (mg) Nicotine Transdermal Patches (NicoDerm CQ, GlaxoSmithKline [GSK] D NCT05024747	HALEON	Phase 1
Completed	N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use NCT04627922	Ellen Herbst	Phase 4
Completed	Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace NCT05110872	Virginia Polytechnic Institute and State University	N/A
Completed	Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes NCT04996940	University of Kansas Medical Center	N/A
Terminated	Study of EMB-001 as a Potential Smoking Cessation Treatment NCT04933916	Embera NeuroTherapeutics, Inc.	Phase 1 / Phase 2
Unknown	Effectiveness of a Smoking Cessation Intervention in a Mental Health Day Hospital NCT05045326	Hospital Clinic of Barcelona	N/A
Unknown	Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment NCT04868253	Rose Research Center, LLC	Phase 2 / Phase 3
Completed	Switching to Potential Reduced Exposure Products in Adult Smokers NCT04250727	Yale University	N/A
Completed	Implementation of Genomics in Substance Use Disorder Treatment NCT04768114	Washington University School of Medicine	N/A
Completed	Smoking Reduction In Gravid Substance Use Disorders NCT04132232	University of Alabama at Birmingham	N/A
Completed	Learn to Quit-HIV Pilot Study NCT04609514	Duke University	N/A
Completed	Development of a mHealth Intervention for Ambivalent Smokers NCT04560868	Kaiser Permanente	Phase 1
Completed	Evaluation of the Addictive Potential of E-Cigarettes NCT04772014	Central Institute of Mental Health, Mannheim	—
Active Not Recruiting	Omega-3 Fatty Acids for Smoking Cessation in Pregnancy NCT04417595	Vanderbilt University Medical Center	Phase 2
Completed	Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders NCT04090879	Brown University	Phase 2
Completed	Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age NCT04092387	University of Vermont	N/A
Completed	Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder NCT04092101	University of Vermont	Phase 2
Completed	Smoking Cessation Treatment for Smokers With Obesity NCT04332029	University of Oviedo	N/A
Completed	Comparative Abuse Liability Among African American and White Smokers NCT04646668	University of Kansas Medical Center	N/A
Completed	Impact of Cigar Flavor in Dual Users NCT04487470	UConn Health	N/A
Completed	Flexiquit+: Web Program to Promote Smoking Cessation in Sexual and Gender Minority Young Adult Smokers NCT04194918	Fred Hutchinson Cancer Center	Phase 1
Unknown	A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder NCT04419922	BrightView LLC	—
Completed	Modification of Alternative Reward Cue Reactivity and Cognitive Control Through Physical Activity in Human Tob NCT04251936	Charite University, Berlin, Germany	N/A
Completed	Cannabis and Tobacco Co-use Study NCT04228965	Medical University of South Carolina	Phase 4
Completed	Modification of Goal-directed and Habitual Behavior in Addiction NCT03764969	Central Institute of Mental Health, Mannheim	N/A
Recruiting	Smoking Cessation Behavioral Treatment Study NCT03948893	University of Missouri-Columbia	N/A
Completed	Brain Imaging in Tobacco Smokers During a Quit Attempt NCT04055467	Johns Hopkins University	Phase 1
Terminated	Mechanisms of Lorcaserin for Smoking Cessation NCT04396834	The Mind Research Network	Phase 2
Completed	Examining the Effects of Neural Stimulation on Inhibitory Control and Cigarette Smoking NCT03960138	University of Missouri-Columbia	N/A
Completed	Deep rTMS and Varenicline for Smoking Cessation NCT04083144	Centre for Addiction and Mental Health	N/A
Completed	Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women NCT04033237	University of Vermont	Phase 1 / Phase 2
Completed	PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness NCT03950427	University of California, San Francisco	Phase 4
Completed	The Effects of Sedatives on Tobacco Use Disorder NCT03813121	Wake Forest University Health Sciences	Phase 1 / Phase 2
Completed	Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI) NCT03873337	Rutgers, The State University of New Jersey	N/A
Recruiting	An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction NCT03713424	University of Missouri-Columbia	Phase 2
Completed	Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck Cancer NCT03788785	Assistance Publique - Hôpitaux de Paris	N/A
Completed	Transcranial Magnetic Stimulation and Tobacco Use Disorder NCT03827265	University of California, Los Angeles	N/A
Completed	An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03553992	University of California, San Francisco	N/A
Completed	A Trial of Directly Observed and Long-term Varenicline NCT03365362	Albert Einstein College of Medicine	Phase 4
Completed	Innovative Digital Therapeutic for Smoking Cessation NCT03694327	My Digital Study	N/A
Completed	Transcranial Direct Current Stimulation - Tobacco Use Disorder NCT03691805	Central Institute of Mental Health, Mannheim	N/A
Completed	Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence NCT03841292	Centre for Addiction and Mental Health	N/A
Withdrawn	Effects of GTS-21 on Smoking Behavior and Neurocognitive Functions NCT02432066	University of Florida	Phase 2
Completed	Addictive Potential of LCCs in Dual Users NCT03496077	UConn Health	N/A
Completed	Text Message Support to Prevent Smoking Relapse NCT02968095	Miami University	N/A
Withdrawn	Combining rTMS With Varenicline to Prevent Smoking Lapse in Schizophrenia NCT03497299	Centre for Addiction and Mental Health	Phase 2
Completed	To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) i NCT03543137	GlaxoSmithKline	Phase 1
Completed	A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers NCT03541044	GlaxoSmithKline	Phase 1
Active Not Recruiting	Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment NCT03519451	M.D. Anderson Cancer Center	N/A
Completed	A Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03259360	University of California, San Francisco	N/A
Completed	Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers NCT03337113	Kent State University	Phase 2
Completed	Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use NCT03402243	University of Minnesota	N/A
Terminated	Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment NCT03213418	New York State Psychiatric Institute	N/A
Completed	Personalized Dosing of Nicotine Replacement (NRT to Effect) NCT03000387	Centre for Addiction and Mental Health	Phase 4
Completed	Smoking Cessation Treatment for Substance Use Dependents NCT03551704	University of Oviedo	N/A
Completed	Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors NCT03386253	University of Minnesota	N/A
Unknown	Smartphone-based Financial Incentives NCT03922360	University of Vermont	N/A
Completed	Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions NCT02888249	Johns Hopkins University	N/A
Completed	Text Messaging and Telephone Counseling for Supporting Post-discharge Quit Attempts NCT03237949	Federal University of Juiz de Fora	N/A
Completed	Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers NCT02906995	Friends Research Institute, Inc.	Phase 1
Completed	Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes NCT03164668	University of Minnesota	N/A
Completed	Optimizing Tobacco Dependence Treatment in the Emergency Department NCT02896400	Yale University	Phase 3
Completed	Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day NCT03060083	University of Vermont	Phase 2 / Phase 3
Completed	Tobacco Pilot Study for Low Income Smokers NCT03017092	University of Wisconsin, Madison	N/A
Completed	Cardiovascular Risk Screening and Risk Reduction in Women Vets NCT02991534	VA Office of Research and Development	N/A
Completed	Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women NCT02952703	University of Wisconsin, Madison	N/A
Completed	Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Diso NCT02232737	Brown University	Phase 1 / Phase 2
Completed	Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women NCT02250534	University of Vermont	Phase 1 / Phase 2
Completed	Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers NCT02250664	University of Vermont	Phase 1 / Phase 2
Active Not Recruiting	Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation NCT02697227	M.D. Anderson Cancer Center	N/A
Completed	RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers NCT02781090	Montefiore Medical Center	N/A
Unknown	Effects of Non-invasive Brain Stimulation in Tobacco Use Disorder NCT02776319	Laval University	N/A
Completed	A Bioequivalence Study of Three, 2 mg Nicotine Chewing Gums (Two Tests and One Reference) in Healthy Adult Smo NCT02688374	GlaxoSmithKline	Phase 1
Unknown	Combining Noninvasive Brain Stimulation and Cognitive Training on Tobacco Craving NCT02810574	Laval University	N/A
Completed	Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers NCT02348203	National Cancer Institute (NCI)	Phase 2
Completed	Effects of Electronic Cigarette Use on the Lungs NCT02596685	Ohio State University Comprehensive Cancer Center	N/A
Completed	Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers NCT02439255	Ohio State University Comprehensive Cancer Center	N/A
Completed	Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc. NCT02601521	Massachusetts General Hospital	N/A
Completed	Effect of Ramelteon on Smoking Abstinence NCT02560324	University of Pennsylvania	Phase 2
Completed	Financial Incentives for Smoking Treatment NCT02506829	NYU Langone Health	N/A
Terminated	Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement NCT02439944	Centre for Addiction and Mental Health	Phase 2 / Phase 3
Completed	The Study of AZD8529 for Smoking Cessation in Female Smokers NCT02401022	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	Text Messaging for Supporting Quit Attempts NCT02571244	Federal University of Juiz de Fora	N/A
Active Not Recruiting	Varenicline and Combined NRT for Smoking Cessation NCT02271919	M.D. Anderson Cancer Center	Phase 4
Completed	Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy NCT02628964	NYU Langone Health	N/A
Completed	Social and Monetary Incentives for Smoking Cessation at Large Employers NCT02421224	University of California, Berkeley	N/A
Completed	Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001) NCT02406066	Embera NeuroTherapeutics, Inc.	Phase 1
Completed	Smoking Cessation Treatment for Depressed Smokers NCT03163056	University of Oviedo	N/A
Completed	Novel Medication as a Potential Smoking Cessation Aid NCT02265367	University of Minnesota	N/A
Unknown	Computer Adaptation of Screening, Brief MET Intervention to Reduce Teen Drinking NCT01881841	Boston Children's Hospital	N/A
Completed	Clinical Trial Tobacco Marijuana NCT02277665	Dartmouth-Hitchcock Medical Center	N/A
Completed	Volitional Dysfunction in Self-control Failures and Addictive Behaviors NCT04498988	Technische Universität Dresden	—
Completed	Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules NCT02169271	National Cancer Institute (NCI)	Phase 2
Completed	Smoking Cessation in Menthol Flavored Cigarette Smokers NCT02342327	University of Minnesota	N/A
Completed	Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers NCT02245308	VA Office of Research and Development	Phase 4
Completed	Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers NCT02123849	National Cancer Institute (NCI)	Phase 2
Completed	The PROMPT Pilot Study NCT03626064	Ottawa Hospital Research Institute	N/A
Completed	Progesterone & Postpartum Relapse to Smoking NCT01798394	University of Minnesota	N/A
Completed	The MATCH (Medication Aids for Tobacco Cessation and Health) Study NCT02146911	Centre for Addiction and Mental Health	N/A
Completed	A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers NCT02188563	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	N/A
Completed	Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers NCT02148445	University of Kansas Medical Center	Phase 3
Completed	Smoking Cessation and a Teachable Moment in Patients With Acute Fractures NCT02781038	University of Pennsylvania	N/A
Withdrawn	Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation NCT02004171	New York State Psychiatric Institute	N/A
Completed	Progesterone for Smoking Relapse Prevention Following Delivery NCT01972464	Yale University	Phase 2
Completed	Medicinal Nicotine for Preventing Cue Induced Craving NCT02347605	University of Minnesota	N/A
Completed	Lorcaserin for Preventing Weight Gain Among Smokers NCT02393547	Mayo Clinic	Phase 1 / Phase 2
Completed	Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers NCT01691105	Yale University	N/A
Completed	Effect of Transcranial Direct Current Stimulation (tDCS) on Tobacco Consumption NCT01930422	University Hospital, Toulouse	N/A
Completed	SBIRT Implementation for Adolescents in Urban Federally Qualified Health Centers NCT01829308	Friends Research Institute, Inc.	N/A
Completed	Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers NCT01796951	Vanderbilt University	EARLY_Phase 1
Completed	Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers NCT01714323	Massachusetts General Hospital	N/A
Completed	Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers NCT01771627	Roswell Park Cancer Institute	N/A
Completed	Effectiveness of Mindfulness Based Relapse Prevention for Tobacco Dependents NCT02327104	Federal University of São Paulo	N/A
Completed	Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking NCT01535040	Wake Forest University Health Sciences	Phase 2
Completed	Effect of Galantamine on Short-term Abstinence NCT01669538	University of Pennsylvania	Phase 2
Completed	Persistence-Targeted Smoking Cessation NCT01654107	Rutgers, The State University of New Jersey	Phase 1
Completed	Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer NCT01673711	University of Minnesota	—
Completed	Tobacco Approach Avoidance Training for Adolescent Smokers-2 NCT01625637	Yale University	Phase 2
Unknown	Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation NCT01566097	Seoul National University Hospital	N/A
Completed	Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 NCT01067599	University of Minnesota	N/A
Completed	Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures NCT01526265	University of Pennsylvania	N/A
Completed	Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms NCT01522963	University of Minnesota	N/A
Completed	Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients NCT01434342	Wake Forest University Health Sciences	EARLY_Phase 1
Completed	Screening to Augment Referral to Treatment- Project START NCT01539525	Yale University	N/A
Completed	Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to S NCT01428310	Rock Creek Pharmaceuticals, Inc.	Phase 1
Terminated	Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers NCT01800500	Roswell Park Cancer Institute	N/A
Completed	Positively Smoke Free on the Web (PSFW) for Smokers Living With HIV NCT01570595	Georgetown University	Phase 1 / Phase 2
Completed	Tobacco Approach Avoidance Training for Adolescent Smokers-1 NCT01625767	Yale University	Phase 2
Completed	Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth NCT01442753	University of Minnesota	N/A
Completed	Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients NCT01378858	Albert Einstein College of Medicine	N/A
Completed	Bupropion for Smoking Cessation During Pregnancy NCT01390246	The University of Texas Medical Branch, Galveston	Phase 4
Completed	Pilot Randomized Control Trial of Financial Incentives for Smoking Cessation NCT01303081	University of Pennsylvania	N/A
Unknown	Standard Medical Care or Urgent Chest X-ray in Diagnosing Lung Cancer in Smokers With Chest Symptoms Who Are O NCT01344005	Wales Cancer Trials Unit	N/A
Completed	Electronic Decision Support Systems for Smokers With Severe Mental Illness NCT01412866	Dartmouth-Hitchcock Medical Center	N/A
Completed	Efficacy of Varenicline for Smokeless Tobacco Use in India NCT01098305	University of Pennsylvania	Phase 2
Completed	A Randomized Trial of Internet Access to Nicotine Patches NCT00534404	University of Michigan	N/A
Completed	Cognitive Training for Nicotine Dependence NCT01252966	University of Pennsylvania	N/A
Completed	Smoking-induced Dopamine Release: a [11C]-(+)-PHNO PET Study in Humans NCT01302262	Centre for Addiction and Mental Health	—
Unknown	QuitAdvisorMD: A Point-of-care Tool for Brief Smoking Cessation Interventions NCT01065493	Silverchair Science & Communications, LLC	Phase 2
Completed	Team-based Financial Incentives for Smoking Cessation NCT01323725	St.Paul's Hospital, Korea	N/A
Completed	Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer NCT01457469	Wake Forest University Health Sciences	Phase 1
Completed	Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit NCT01308736	Rutgers, The State University of New Jersey	N/A
Unknown	Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin Schools NCT01306552	Charite University, Berlin, Germany	N/A
Completed	Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in NCT01337830	Star Scientific, Inc	Phase 1
Completed	Treating Low-Income Smokers in the Hospital Emergency Department NCT01328431	Yale University	N/A
Completed	Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers NCT01021215	National Cancer Institute (NCI)	Phase 1 / Phase 2
Completed	Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts NCT01023659	Centre for Addiction and Mental Health	Phase 4
Completed	A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers NCT01262170	Rock Creek Pharmaceuticals, Inc.	Phase 1
Completed	Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine NCT00710034	University of Minnesota	Phase 2
Completed	Neural Substrates in Nicotine Withdrawal NCT01001520	University of Pennsylvania	Phase 2
Completed	Screening Protocol for Research Participants NCT01010620	University of Maryland, Baltimore	—
Completed	Tobacco Zero: Interactive Tobacco Education for Teens NCT00670995	Deschutes Research, Inc.	Phase 2
Completed	Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving NCT01329614	Columbia University	EARLY_Phase 1
Completed	Lung HIV Microbiome Project (Michigan Site) NCT02392182	University of Michigan	—
Completed	N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers NCT00967005	University of Chicago	Phase 2
Completed	A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers NCT01337817	Star Scientific, Inc	Phase 1
Completed	Tobacco Treatment Medical Education in 10 Medical Schools NCT01905618	University of Massachusetts, Worcester	N/A
Completed	Examining a Text Message Intervention for Smoking Cessation NCT01166464	The Miriam Hospital	N/A
Completed	A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge NCT01336816	Star Scientific, Inc	Phase 1
Completed	Acceptability of Less Harmful Alternatives to Cigarettes NCT00957424	Roswell Park Cancer Institute	N/A
Completed	Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls NCT01214005	Brown University	Phase 2
Completed	Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users NCT00820495	Oregon Research Institute	Phase 2
Completed	Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy NCT00888979	Hartford Hospital	N/A
Completed	p16 Methylation for Smoking Cessation NCT01038492	Duke University	N/A
Unknown	Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes NCT00865553	University of Vermont	Phase 2
Completed	Fresh Lime Alone for Smoking Cessation NCT01333202	Thai Health Professional Alliance Against Tobacco	N/A
Completed	Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers NCT00691132	University of Minnesota	Phase 2
Completed	Treatment of Smoking Among Individuals With PTSD NCT00937235	University of Pennsylvania	Phase 2
Completed	A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward NCT00830739	National Institute on Drug Abuse (NIDA)	—
Completed	Innovative Interventions for Smoking Cessation NCT01050569	University of Minnesota	Phase 2
Unknown	Screening Methods in Finding Lung Cancer Early in Current or Former Smokers NCT00751660	British Columbia Cancer Agency	N/A
Completed	Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smokin NCT00790569	Butler Hospital	N/A
Completed	Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction NCT00871637	University of Nebraska	—
Completed	Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers NCT00711100	University of Minnesota	N/A
Completed	Calcitriol in Preventing Lung Cancer in Smokers and Former Smokers at High Risk of Lung Cancer NCT00690924	Roswell Park Cancer Institute	N/A
Completed	Acute Effects of Smoking on Airway Dendritic Cells NCT00740896	University of Rostock	N/A
Completed	Smoking Termination Opportunity for inPatients NCT01141855	The Queen Elizabeth Hospital	Phase 2 / Phase 3
Completed	Nicotine Patch Pretreatment for Smoking Cessation in PTSD NCT00625131	US Department of Veterans Affairs	EARLY_Phase 1
Unknown	Biomarkers for Early Detection of Lung Cancer in Patients With Lung Cancer, Participants at High-Risk for Deve NCT00899262	South West Wales Cancer Institute	—
Completed	Treating Tobacco Dependence in Adolescents With Co-occurring Psychiatric Disorders NCT00618943	University of California, San Francisco	Phase 3
Completed	Efficacy of Varenicline in Ambivalent Smokers NCT00595868	University of Vermont Medical Center	Phase 2
Completed	Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum NCT00573885	British Columbia Cancer Agency	Phase 2
Completed	Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail NCT00618280	Heinrich-Heine University, Duesseldorf	Phase 1 / Phase 2
Completed	Tobacco Use Intervention Among Radiation Oncology Patients NCT00587353	Mayo Clinic	Phase 2
Unknown	Cancer Risk Reduction Through Combined Treatment for Tobacco and Alcohol Use NCT00799669	M.D. Anderson Cancer Center	—
Completed	Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking NCT00666978	Lisa Sanderson Cox, PhD	Phase 4
Completed	Clinical Effort Against Secondhand Smoke (CEASE) Program or Standard Care in Helping Parents Stop Smoking NCT00664261	Massachusetts General Hospital	N/A
Active Not Recruiting	Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at R NCT00542373	M.D. Anderson Cancer Center	N/A
Unknown	A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers. NCT00396669	Hadassah Medical Organization	N/A
Completed	Chantix & Bupropion for Smoking Cessation NCT00587769	Mayo Clinic	Phase 3
Completed	Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults NCT01497158	University of Minnesota	N/A
Completed	Varenicline Effects In Schizophrenic Smokers NCT00548470	Nathan Kline Institute for Psychiatric Research	Phase 4
Unknown	Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers NCT00429208	Hadassah Medical Organization	N/A
Completed	Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3 NCT00136786	New York State Psychiatric Institute	Phase 1
Completed	Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use NCT00218296	University of Minnesota	Phase 2
Unknown	Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation NCT00419731	University of Minnesota	Phase 2 / Phase 3
Terminated	Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia NCT00611650	British Columbia Cancer Agency	Phase 2
Completed	Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci NCT00365209	National Cancer Institute (NCI)	Phase 2
Completed	Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia NCT00368927	National Cancer Institute (NCI)	Phase 2
Completed	Lung Rehabilitation in Treating Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Surgery NCT00363428	Mayo Clinic	N/A
Completed	Treating Tobacco Dependence in Inpatient Psychiatry - 1 NCT00136812	Stanford University	N/A
Completed	Intensive Intervention for Smokers - 6 NCT00217984	University of California, San Francisco	N/A
Completed	Computer-Based Stop Smoking Program in Assisting Doctors in Helping Adults Stop Smoking NCT00383461	Brigham and Women's Hospital	N/A
Completed	Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking NCT00365508	Fox Chase Cancer Center	Phase 4
Completed	Bupropion in Helping Adults Stop Smoking NCT00534001	Roswell Park Cancer Institute	Phase 2
Unknown	CHERL, Connecting Primary Care Patients With Community Resources to Facilitate Behavior Change NCT00269009	Great Lakes Research Into Practice Network	Phase 1
Completed	Pharmacogenetics, Emotional Reactivity and Smoking NCT00507728	M.D. Anderson Cancer Center	Phase 2 / Phase 3
Terminated	Baclofen Effects on Smoking Urge and Withdrawal NCT00257894	VA Office of Research and Development	Phase 2
Completed	Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1 NCT00218439	University of Minnesota	N/A
Completed	Randomized Trial Assessing the Effectiveness of a Pharmacist-Delivered Program for Smoking Cessation NCT00670904	University of Montana	N/A
Completed	Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2 NCT00158145	National Institute on Drug Abuse (NIDA)	—
Completed	Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2 NCT00158158	National Institute on Drug Abuse (NIDA)	Phase 2 / Phase 3
Completed	Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1 NCT00218179	University of Minnesota	—
Completed	A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches NCT00134927	National Institute on Drug Abuse (NIDA)	—
Completed	Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia NCT01213524	Brown University	Phase 2
Completed	Selegiline Patch for Treatment of Nicotine Dependence NCT01330030	Stanford University	Phase 2
Completed	Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction NCT00264342	University of California, San Francisco	—
Completed	Smoking Treatment of Prisoners NCT00110630	National Institute on Drug Abuse (NIDA)	Phase 3
Completed	Financial Incentives for Smoking Cessation NCT00128375	University of Pennsylvania	N/A
Terminated	Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women NCT00119210	Massachusetts General Hospital	Phase 4
Completed	Nicotine Lozenge to Reduce Smokeless Tobacco Use NCT00218283	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving NCT00208858	Emory University	Phase 2
Completed	Registration of Tobacco, Coffee and Substance Use Among Acutely Admitted Psychiatric Patients NCT00184184	Norwegian University of Science and Technology	—
Completed	Effect of Progesterone on Smoking Behavior in Male and Female Smokers NCT00271206	Yale University	Phase 1
Completed	Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence NCT00178685	University of Rochester	Phase 4
Completed	Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Postt NCT00118534	US Department of Veterans Affairs	N/A
Completed	Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2 NCT00135746	National Institute on Drug Abuse (NIDA)	N/A
Completed	Effectiveness of Bupropion for Treating Nicotine Dependence in Young People NCT00129272	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	Behavioral Smoking Cessation Treatment - 1 NCT00110825	National Institute on Drug Abuse (NIDA)	N/A
Completed	The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1 NCT00136747	New York State Psychiatric Institute	Phase 1
Completed	Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia NCT00218231	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals NCT00308763	University of Tennessee	N/A
Completed	Zinc Supplements in Lowering Cadmium Levels in Smokers NCT00376987	Wake Forest University Health Sciences	Phase 2
Completed	Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2 NCT00135772	National Institute on Drug Abuse (NIDA)	—
Completed	Non-Nicotine Agents for Smoking Cessation NCT00108537	US Department of Veterans Affairs	Phase 3
Completed	Dental Tobacco Control.Net:Improving Practice NCT00627185	University of Alabama at Birmingham	EARLY_Phase 1
Completed	Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia NCT00136760	Brown University	Phase 2
Completed	Comparing Smoking Treatment Programs for Lighter Smokers - 1 NCT00086411	University of Pennsylvania	Phase 2
Completed	Improving Smoking Cessation Outcomes in Heavy Drinkers - 1 NCT00107575	Brown University	Phase 2
Completed	Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents NCT00258479	Catherine Martin, MD	Phase 1
Completed	Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1 NCT00067158	New York University	Phase 3
Completed	Tobacco Cessation Field Study for Adults in Recovery - 1 NCT00109460	Inflexxion, Inc.	Phase 2
Completed	Primary Care Physicians' Use of Stop-Smoking Plans to Help Patients Who Are Smokers NCT00227786	Kaiser Permanente	N/A
Completed	Maintaining Abstinence in Chronic Cigarette Smokers - 1 NCT00087880	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use NCT00218270	National Institute on Drug Abuse (NIDA)	Phase 2

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