| Not Yet Recruiting | Sevoflurane Sedation in Patients With Septic Shock NCT03643367 | University of Zurich | Phase 2 |
| Terminated | Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator NCT06426407 | The Cleveland Clinic | — |
| Not Yet Recruiting | "Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools" NCT04934943 | Humanitas Clinical and Research Center | — |
| Not Yet Recruiting | Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock NCT06581172 | Assiut University | — |
| Recruiting | Types of Photoplethysmographic Waves in Adult Patients with Septic Shock NCT06786364 | Hospital General de México Dr. Eduardo Liceaga | — |
| Recruiting | Early Intravenous Hydrocortisone in Sepsis NCT06217939 | Siriraj Hospital | N/A |
| Completed | Comparison of Peripheral Perfusion Indicators and Lactate Levels NCT06727318 | Gulhane Training and Research Hospital | — |
| Recruiting | Early Severe Illness TrAnslational BioLogy InformaticS in Humans NCT05591924 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Not Yet Recruiting | Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock NCT06306001 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 2 / Phase 3 |
| Unknown | Impact of an Echographic Algorithm on Hemodynamic Optimization in the First 4 Days of Septic Shock Management NCT06043505 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Recruiting | Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK NCT06062303 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Multimodal Vasopressor Strategy in Septic Shock NCT06155812 | University Medical Centre Maribor | Phase 2 / Phase 3 |
| Recruiting | Early Initiated Vasopressor Therapy in the Emergency Department NCT05931601 | Odense University Hospital | Phase 3 |
| Unknown | Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medi NCT04910841 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Pituitary Function After Recovery From Septic Shock Among ICU Survivors NCT05990491 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Completed | The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients With Septic Sho NCT05902273 | Bezmialem Vakif University | — |
| Completed | Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial NCT05249088 | Region Skane | N/A |
| Recruiting | Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting NCT05688774 | Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps | — |
| Active Not Recruiting | Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis NCT04569942 | Australian and New Zealand Intensive Care Research Centre | Phase 3 |
| Recruiting | Management of Shock in Children With SAM or Severe Underweight and Diarrhea NCT04750070 | International Centre for Diarrhoeal Disease Research, Bangladesh | Phase 3 |
| Completed | Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures NCT05961137 | Orange Park Medical Center | N/A |
| Completed | Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis NCT04576819 | University of Florida | — |
| Completed | Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shoc NCT04647552 | Inonu University | — |
| Unknown | 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension NCT05441878 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 4 |
| Unknown | Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in P NCT04182737 | Massimo Girardis | Phase 3 |
| Unknown | Peer Support for Post Intensive Care Syndrome Self-Management NCT03788096 | University of Texas at Austin | N/A |
| Completed | Fluid Overload Quantification in Septic Shock NCT04114162 | Centre Hospitalier Universitaire de Besancon | — |
| Unknown | Early Identification of Sepsis in Children NCT03884595 | Brno University Hospital | — |
| Completed | Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic NCT04178148 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Active Not Recruiting | Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock NCT04055909 | Inotrem | Phase 2 |
| Unknown | Postoperative Respiratory Abnormalities NCT04079829 | Efficacy Care R&D Ltd | — |
| Unknown | Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery NCT04388267 | Central Hospital, Nancy, France | — |
| Unknown | Usefulness of Capillary Refill Time and Skin Mottling Score to Predict Intensive Care Unit Admission NCT03831022 | Hôpital Necker-Enfants Malades | — |
| Suspended | Neuromuscular Electrical Stimulation and Septic Shock NCT03193164 | University of Sao Paulo | N/A |
| Terminated | Vitamin C, Hydrocortisone and Thiamine for Septic Shock NCT03592693 | University of Athens | Phase 2 |
| Completed | The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial NCT03333278 | Australian and New Zealand Intensive Care Research Centre | Phase 2 |
| Terminated | L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury NCT02664753 | Centre Hospitalier Universitaire de Nīmes | Phase 3 |
| Completed | Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study NCT03340805 | Children's Hospital of Philadelphia | Phase 1 |
| Withdrawn | Midodrine During Recovery From Septic Shock NCT02771158 | Northwell Health | Phase 4 |
| Completed | Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients Wit NCT03158948 | Inotrem | Phase 2 |
| Completed | Fluid Responsiveness in HFNC Patients NCT03817996 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Withdrawn | Thiamine Supplementation in Patients With Septic Shock NCT03122678 | The Cleveland Clinic | Phase 1 |
| Withdrawn | Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Sh NCT02609152 | Centre Hospitalier Universitaire de Nīmes | Phase 3 |
| Completed | Targeted Tissue Perfusion Versus Macrocirculatory-guided Standard Care in Patients With Septic Shock NCT02579525 | Helsinki University Central Hospital | N/A |
| Terminated | Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock NCT02716597 | Alexander Flannery, 859-323-4011 | Phase 1 |
| Completed | Strain Echocardiography During Septic Shock : an Observational Pilot Study NCT03663192 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Place of Echocardiography in IV Fluid Therapy in Patients With Septic Shock and Left Ventricular Systolic Dysf NCT02899897 | Centre Hospitalier Universitaire, Amiens | — |
| Withdrawn | NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock NCT02454348 | University of Arkansas | Phase 4 |
| Completed | Clinical Practice Guidelines and Impact of Audit and Feedback in the Emergency Department NCT02427048 | Denver Health and Hospital Authority | N/A |
| Terminated | Sepsis Assessment in Belgian Emergency Rooms NCT02424721 | Axis Shield Diagnostics Ltd | — |
| Completed | Anticholium® Per Se NCT03013322 | University Hospital Heidelberg | N/A |
| Completed | Balanced Salt Solution VS. Normal Saline Solution in Septic Shock NCT02336620 | Ramathibodi Hospital | Phase 3 |
| Unknown | Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients NCT02842983 | Peking Union Medical College Hospital | Phase 2 / Phase 3 |
| Terminated | Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test NCT02301585 | Karolinska Institutet | N/A |
| Terminated | COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2 NCT01639664 | Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva | N/A |
| Unknown | Polydatin Injectable (HW6) for Shock Treatment NCT01780129 | Neptunus Pharmaceuticals Inc. | Phase 2 |
| Completed | Can Shock Indices Be Prognostic Indicators in Sepsis/Septic Shock? NCT06415006 | Başakşehir Çam & Sakura City Hospital | — |
| Withdrawn | Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients NCT01601938 | Gil Joon Suh | Phase 2 |
| Completed | Mitochondrial Function of Immune Cells in Sepsis NCT01600989 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial NCT01453270 | National University Hospital, Singapore | N/A |
| Unknown | Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients Wit NCT01213914 | American Burn Association | N/A |
| Completed | Medical Education for Sepsis Source Control and Antibiotics NCT01187134 | Center for Sepsis Control and Care, Germany | N/A |
| Completed | Study of Progression of Community Acquired Pneumonia in the Hospital NCT02782013 | Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps | — |
| Completed | Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Predicti NCT01231672 | Centre Hospitalier Universitaire de Nīmes | — |
| Terminated | COMPACT - COMbining Plasma-filtration and Adsorption Clinical Trial NCT00332371 | Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva | N/A |
| Completed | Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock NCT01310790 | Chinese Septic Shock Network | Phase 4 |
| Unknown | Protocol-driven Hemodynamic Support for Patients With Septic Shock NCT00335907 | National Institute of General Medical Sciences (NIGMS) | N/A |
| Unknown | Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests NCT00258869 | National Center for Genome Resources | — |
| Completed | Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care) NCT00241228 | University Hospital, Bordeaux | N/A |
| Completed | Tryptophan, Serotonin and Kynurenine in Septic Shock NCT00684736 | Versailles Hospital | — |
| Completed | Corticosteroid Therapy of Septic Shock - Corticus NCT00147004 | Hadassah Medical Organization | Phase 3 |
| Completed | A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis NCT00046072 | Eisai Inc. | Phase 2 |
| Completed | Comparison of Vasopressin and Other Pressors in Septic Shock NCT00269685 | Université de Sherbrooke | Phase 2 / Phase 3 |
| Completed | Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis NCT00406198 | Hopital Lariboisière | Phase 4 |
| Completed | Ibuprofen in Sepsis Study NCT00000574 | Vanderbilt University | Phase 3 |