NCT04178148

Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Amikacin dose optimization is challenging in critically ill patients. The use of BestDose software algorithm-based drug optimization could help to achieve the recommended target concentrations (60-80 mg/L) after administration of the second dose of amikacin, associated with improved outcome. The study investigators hypothesize that 80% of patients undergoing drug dosing optimization using the BestDose software in the interventional group will reach the predefined PK/PD targets.

Conditions

• Shock, Septic

Interventions

Type	Name	Description
OTHER	Amikacin dose optimization	Therapeutic drug optimization of amikacin using the BestDose software algorithm

Timeline

• Start date: 2019-11-25
• Primary completion: 2022-12-02
• Completion: 2022-12-02
• First posted: 2019-11-26
• Last updated: 2025-12-10

Locations

1 site across 1 country: France