| Not Yet Recruiting | Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy NCT07493395 | University Hospital, Montpellier | Phase 2 |
| Recruiting | Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Di NCT07292961 | Hacettepe University | N/A |
| Recruiting | Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis NCT06256575 | Primus Pharmaceuticals | N/A |
| Completed | Efficacy of Tofacitinib on Skin Thickening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With M NCT07472166 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Phase 4 |
| Recruiting | Periodontal Microbiota in Systemic Sclerosis NCT06182293 | University Hospital, Strasbourg, France | N/A |
| Active Not Recruiting | Development and Evaluation of an Evidence-based Education Program for People With Hand Dysfunction in Sclerode NCT06697561 | Wen-Shao Lin | N/A |
| Unknown | Subcutaneous Semaglutide in Systemic Scleroderma NCT06149260 | Second Xiangya Hospital of Central South University | Phase 1 |
| Completed | Making it Work Program for Systemic Sclerosis NCT06338722 | University of New Mexico | N/A |
| Recruiting | A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung NCT05878717 | GlaxoSmithKline | Phase 2 / Phase 3 |
| Completed | Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism NCT05961267 | University Hospital, Bordeaux | — |
| Unknown | Leap Motion Based Gamefication Exercises in the Individuals With Systemic Sclerosis NCT05821335 | Istanbul University | N/A |
| Completed | A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Functio NCT05559580 | Boehringer Ingelheim | Phase 2 |
| Completed | Phenotyping of Chronic Pain in Diffused Systemic Scleroderma NCT05622578 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Western Sweden Systemic Sclerosis Project NCT07345052 | Sahlgrenska University Hospital | — |
| Unknown | Novel Splinting Technique Using 3D Models NCT05351060 | Giovanna Fichera | N/A |
| Unknown | Effectiveness of Telerehabilitation on Scleroderma NCT04563481 | Istanbul University | N/A |
| Completed | Scleroderma: Functional Disability Between the Dominant and Contralateral Hand. NCT05171114 | University Hospital, Limoges | N/A |
| Recruiting | Trichoscopy and Systemic Scleroderma NCT04804930 | University Hospital, Lille | — |
| Unknown | Functional Exercise Tests in Patients With Systemic Sclerosis NCT04650659 | University of Aarhus | — |
| Completed | Effects of FT011 in Systemic Sclerosis NCT04647890 | Certa Therapeutics | Phase 2 |
| Recruiting | Effect of the Use of Specific Oral Hygiene Devices on Gingival Health Among Patients With Systemic Sclerosis NCT04627857 | University Hospital, Strasbourg, France | N/A |
| Active Not Recruiting | Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases NCT04922736 | University of Utah | N/A |
| Terminated | A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients NCT04837131 | Michael M. Pham | Phase 2 |
| Completed | A Study of Guselkumab in Participants With Systemic Sclerosis NCT04683029 | Janssen Pharmaceutical K.K. | Phase 2 |
| Completed | The Influence of Extracorporeal Photopheresis on Skin Sclerosis NCT04752397 | Charite University, Berlin, Germany | — |
| Completed | Exercise With Scleroderma Functional Outcomes NCT06425653 | Trakya University | N/A |
| Completed | microRNAs in Systemic Scleroderma NCT04148716 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Telerehabilitation on Hand-Affected Scleroderma NCT04684225 | Istanbul University | N/A |
| Unknown | Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia NCT04746599 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | N/A |
| Recruiting | Pilot Study of Description of Cicatrisation Rates of Digital Ulcers in Systemic Scleroderma NCT04319120 | University Hospital, Limoges | — |
| Completed | Evaluation of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Togethe NCT04335279 | Lady Davis Institute | N/A |
| Completed | The SPIN - Scleroderma Support Group Leader EDucation Program Trial (SPIN-SSLED) NCT03965780 | Lady Davis Institute | N/A |
| Completed | The Benefit of Bermekimab in Patients With Systemic Sclerosis NCT04045743 | Hellenic Institute for the Study of Sepsis | Phase 2 |
| Completed | A Study to Test Whether Nintedanib Influences the Components of Birth-control Pills in Women With Systemic Scl NCT03675581 | Boehringer Ingelheim | Phase 1 |
| Completed | Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis. NCT03559465 | University Hospital, Lille | N/A |
| Unknown | Pragmatic Clinical Trials in Scleroderma NCT03610217 | University of West London | N/A |
| Completed | Gut Microbiota Transplantation in Systemic Sclerosis NCT03444220 | Oslo University Hospital | Phase 1 / Phase 2 |
| Completed | A Study of the Efficacy and Safety of Rituximab in Participants With Systemic Sclerosis NCT04274257 | Tokyo University | Phase 2 / Phase 3 |
| Completed | Scleroderma Lung Study III - Combining Pirfenidone With Mycophenolate NCT03221257 | Michael Roth | Phase 2 |
| Completed | Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study NCT03120533 | University Hospital, Grenoble | Phase 1 / Phase 2 |
| Unknown | Impact of Education and Training of Modified Rodnan Skin Scoring on the Reliability of Test NCT03219606 | Seoul National University Hospital | N/A |
| Completed | Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis NCT03041025 | GlaxoSmithKline | Phase 2 |
| Completed | Immunomodulating Effects of Supplementation With 25-OH Vitamin D NCT04822038 | Coordinación de Investigación en Salud, Mexico | N/A |
| Unknown | Health-related Quality of Life in Korean Patients With Rheumatic Diseases NCT03257878 | Seoul National University Hospital | — |
| Active Not Recruiting | Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypert NCT02682511 | Cumberland Pharmaceuticals | Phase 2 |
| Completed | Obstructive Sleep Apnea in Scleroderma and Pulmonary Involvement NCT02740569 | Marmara University | — |
| Completed | Role of Circulating Cytotoxic Lymphocytes in Endothelial Cell Injury in Systemic Sclerosis NCT02636127 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis NCT02597933 | Boehringer Ingelheim | Phase 3 |
| Completed | The Impact of Illness Perceptions on Health Related Outcomes in Patients With Lupus and Systemic Sclerosis NCT02655640 | Universitaire Ziekenhuizen KU Leuven | — |
| Terminated | Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Pati NCT02558543 | Assistance Publique Hopitaux De Marseille | Phase 2 |
| Completed | The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis NCT02480335 | University Medical Center Groningen | Phase 4 |
| Terminated | Oral Manifestations of Systemic Sclerosis NCT02371005 | University Hospital, Strasbourg, France | N/A |
| Completed | A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of GSK2330811 in Healthy Subjects NCT02386436 | GlaxoSmithKline | Phase 1 |
| Completed | Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis NCT02283762 | Bayer | Phase 2 |
| Completed | Light Treatment for Scleroderma Finger Ulcers NCT02472743 | University of Manchester | N/A |
| Completed | Swallowing Difficulties With Medication Intake and Coping Strategies in Patients With Systemic Sclerosis NCT02105818 | Kurt Hersberger | — |
| Completed | A Comparison Between Two Educational Methods in the Rehabilitation of the Microstomia in Systemic Sclerosis NCT03766243 | IRCSS Istituto Dermopatico dell'Immacolata, Fondazione Luigi Maria Monti | N/A |
| Terminated | Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effec NCT01559129 | Celgene | Phase 2 |
| Unknown | Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study NCT01554540 | University Hospital, Grenoble | Phase 1 / Phase 2 |
| Completed | Laser Speckle Contrast Imaging for Cutaneous Microvascular Dysfunction Detection in Systemic Sclerosis. NCT01743612 | University Hospital, Grenoble | N/A |
| Terminated | Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial NCT01445821 | Northwestern University | Phase 3 |
| Completed | Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis NCT01347008 | Federal University of São Paulo | Phase 3 |
| Withdrawn | Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients NCT01202045 | Paul Farand | — |
| Completed | A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Sclerode NCT00442611 | Stanford University | Phase 1 / Phase 2 |
| Completed | A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Pa NCT00725361 | Stanford University | N/A |
| Completed | Efficacy and Safety of Imatinib in Scleroderma NCT00479934 | University Hospital, Bordeaux | Phase 2 |
| Completed | Imatinib in Systemic Sclerosis NCT00506831 | Stanford University | Phase 1 / Phase 2 |
| Unknown | Platelet Gel in Systemic Sclerosis NCT00463125 | Università Politecnica delle Marche | Phase 2 / Phase 3 |
| Completed | Efficacy and Safety Study of GB-0998 for Treatment of Systemic Sclerosis NCT00348296 | Benesis Corporation | Phase 3 |
| Completed | Pulmonary Involvement in Scleroderma: A Clinical Study of the Safety and Efficacy of Mycophenolate Mofetil in NCT00333437 | University of California, San Francisco | N/A |
| Completed | Scleroderma: Cyclophosphamide or Transplantation NCT00114530 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 / Phase 3 |
| Completed | SCOT Scleroderma Treatment Alternative Registry (STAR Registry) NCT00860548 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma NCT00070590 | Actelion | Phase 2 / Phase 3 |
| Completed | Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome NCT00025818 | Allergan | Phase 3 |
| Terminated | Thalidomide for Decreasing Collagen Biosynthesis in People With Progressive Systemic Sclerosis NCT00418132 | NYU Langone Health | Phase 1 |
| Completed | Scleroderma Lung Disease NCT00004563 | The University of Texas Health Science Center, Houston | Phase 3 |
| Completed | Study of Silicone-Associated Connective Tissue Diseases NCT00001330 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | — |
| Completed | Idiopathic Pulmonary Fibrosis--Pathogenesis and Staging - SCOR in Occupational and Immunological Lung Diseases NCT00005317 | National Heart, Lung, and Blood Institute (NHLBI) | — |