NCT03559465

Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 71 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

B Lymphocytes are thought to play an important role in the pathophysiology of systemic sclerosis. In this study, the profibrosing role of B lymphocytes of patients with systemic sclerosis will be evaluated.

Detailed description

B Lymphocytes of patients with systemic sclerosis will be assessed in term of interaction with fibroblasts from patients with systemic sclerosis and compared to healthy controls.

Conditions

• Scleroderma, Systemic

Interventions

Type	Name	Description
PROCEDURE	skin biopsy	A skin biopsy will be performed in 10 patients in the form of 2 punches of 5 mm in the injured area in aseptic condition with a Rodnan score. In this study, 10 skin biopsies are needed, and will be performed on the first 10 patients accepting this biopsy.
OTHER	Blood punction	1 blood punction during the normal pathway of care of the patient. This punction will be used to perform the extraction of B lymphocyte

Timeline

• Start date: 2018-10-29
• Primary completion: 2023-02-14
• Completion: 2023-02-14
• First posted: 2018-06-18
• Last updated: 2025-12-23

Locations

1 site across 1 country: France