| Not Yet Recruiting | High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room NCT06489379 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Effect of Implementing Sleep Care Bundle on Nurses' Practice and Patients' Outcomes NCT06775210 | Mansoura University | N/A |
| Recruiting | The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventila NCT06203405 | Siriraj Hospital | N/A |
| Completed | Utility of Defining ARDS and Past and Current Definitions of ARDS NCT06159465 | NMC Specialty Hospital | — |
| Unknown | Lung Overdistension and Abdominal Pressure Rise NCT06174636 | University of Padova | N/A |
| Unknown | Determine the Effects of Prone Positioning and NO in COVID-19 ARDS by EIT NCT05715762 | Shanghai Zhongshan Hospital | — |
| Terminated | Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory NCT04012073 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Phase 3 |
| Enrolling By Invitation | Pre-hospital Ventilation Clinical Study NCT05604430 | Zoll Medical Corporation | — |
| Completed | Awake Prone Positioning in Moderate to Severe COVID-19 NCT05083130 | Oxford University Clinical Research Unit, Vietnam | N/A |
| Completed | Ventilation and Perfusion in the Respiratory System NCT05081895 | University of California, San Diego | — |
| Terminated | Safety and Efficacy of USB002 for Respiratory Distress Due to COVID-19 NCT04778059 | US Biotest, Inc. | Phase 2 |
| Recruiting | Trial of Therapeutic Hypothermia in Patients With ARDS NCT04545424 | University of Maryland, Baltimore | Phase 2 |
| Completed | Roflumilast as add-on Therapy in Early Cases of ARDS NCT04744090 | Cairo University | Phase 2 |
| Completed | High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients NCT04710329 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Completed | A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS NCT04582201 | MiNK Therapeutics | Phase 1 |
| Withdrawn | Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients NCT04508933 | Istanbul University - Cerrahpasa | — |
| Completed | Telmisartan in Respiratory Failure Due to COVID-19 NCT04510662 | Abraham Edgar Gracia-Ramos | Phase 2 |
| Unknown | Prevalence and Kinetics of Diaphragmatic Dysfunction in Elderly Patients With Acute Respiratory Distress NCT04520815 | Centre Hospitalier Universitaire de la Réunion | — |
| Completed | COVID-19 Treatment of Severe Acute Respiratory Syndrome With Veru-111 NCT04388826 | Veru Inc. | Phase 2 |
| Terminated | Dexamethasone for COVID-19 Related ARDS: a Multicenter, Randomized Clinical Trial NCT04395105 | Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno | Phase 3 |
| Terminated | Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms NCT04382391 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Completed | Characteristics and Outcomes of Patients With COVID-19 Admitted to the ICU NCT04378582 | University of Sao Paulo General Hospital | — |
| Completed | Spironolactone in Covid-19 Induced ARDS NCT04345887 | Istanbul University - Cerrahpasa | — |
| Unknown | Peer Support for Post Intensive Care Syndrome Self-Management NCT03788096 | University of Texas at Austin | N/A |
| Terminated | Dexamethasone Treatment for Severe Acute Respiratory Distress Syndrome Induced by COVID-19 NCT04347980 | Centre Chirurgical Marie Lannelongue | Phase 3 |
| Unknown | Coronavirus Studied by Metagenomics in ARDS COVID-19 Patients NCT04516486 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit NCT04297397 | Guy's and St Thomas' NHS Foundation Trust | — |
| Unknown | Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON) NCT04228471 | University Hospital, Bonn | N/A |
| Terminated | The Strategy of "Pulmonary Opening by Titration of Positive End-expiratory Pressure" Means of a Pulmonary Recr NCT04028336 | Centre Hospitalier de Lens | N/A |
| Completed | Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome NCT03818854 | Michael A. Matthay | Phase 2 |
| Completed | Early Use of Prone Position in ECMO for Severe ARDS NCT04139733 | Beijing Chao Yang Hospital | — |
| Unknown | The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS W NCT03971331 | Kang Yan | N/A |
| Completed | Iloprost in Acute Respiratory Distress Syndrome NCT03111212 | University Hospital Tuebingen | Phase 3 |
| Completed | PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury NCT03969914 | Università degli Studi di Ferrara | — |
| Completed | Prevalence, Impact and Reversibility of Acute Diaprhagmatic Dysfunction in Acute Respiratory Detresse NCT04106128 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma NCT03368092 | University Hospital, Strasbourg, France | Phase 3 |
| Completed | Efficacy and Safety Study of HLCM051(MultiStem®) for Pneumonic Acute Respiratory Distress Syndrome NCT03807804 | Healios K.K. | Phase 2 |
| Completed | Weaning From Nasal High Flow Therapy NCT05210881 | Hôpital Louis Mourier | — |
| Active Not Recruiting | Long Term Follow up of Children Enrolled in the REDvent Study NCT03709199 | Children's Hospital Los Angeles | — |
| Completed | STUDY OF ELECTRICAL STIMULATION IN PULMONARY FUNCTION IN INTENSIVE CARE UNIT NCT03712215 | Universidade Metodista de Piracicaba | N/A |
| Withdrawn | Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS NCT03376854 | University of Maryland, Baltimore | Phase 2 |
| Completed | Identifying PARDS Endotypes NCT03539783 | Children's Hospital Medical Center, Cincinnati | — |
| Completed | The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium NCT03337373 | Mahidol University | Phase 4 |
| Completed | Practice of Ventilation in Middle-Income Countries NCT03188770 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Unknown | Measuring Heart and Lung Function in Critical Care NCT03424798 | University of Oxford | — |
| Unknown | Establishment of a Biomarkers-based Early Warning System of Acute Respiratory Distress Syndrome (ARDS) NCT03236272 | Mingdong Hu | — |
| Completed | The Role of Morphological Phenotype in ARDS NCT04157946 | Hospital El Cruce | — |
| Completed | Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS NCT03202394 | BioMarck Pharmaceuticals, Ltd. | Phase 2 |
| Completed | Risk Factors and Prediction Score of ARDS After Cardiac Surgery NCT02759770 | Beijing Anzhen Hospital | — |
| Terminated | Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS NCT02252094 | National University Health System, Singapore | N/A |
| Completed | Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO) NCT06199141 | University of Padova | — |
| Completed | Correlation of Survival in Puerperae by Electrical Impedance Tomography NCT03715647 | Amazon University | — |
| Completed | Abnormalities in Lung Computed Tomography and Physiological Alterations in Patients With Acute Respiratory Dis NCT02799940 | Hospital Regional Rio Gallegos | — |
| Terminated | PGE1 as Additive Anticoagulant in ECMO-Therapy NCT02895373 | Thomas Staudinger | Phase 2 |
| Completed | Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome NCT02732041 | Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno | — |
| Completed | Hemodynamic Assessment With Trans-esophageal Doppler (TED) During Prone Ventilation in ARDS Patients NCT02664090 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Terminated | Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome NCT02622724 | Faron Pharmaceuticals Ltd | Phase 3 |
| Unknown | Non-invasive Fluid Management NCT02892799 | Intermountain Health Care, Inc. | N/A |
| Completed | New Lung Ventilation Strategies Guided by Transpulmonary Pressure in VV-ECMO for Severe ARDS NCT02439151 | Rui Wang | N/A |
| Terminated | Treprostinil Sodium Inhalation for Patients At High Risk for ARDS NCT02370095 | University of North Carolina, Chapel Hill | Phase 2 |
| Unknown | Esophageal Pressure-Guided Optimal PEEP/mPaw in CMV and HFOV: The EPOCH Study NCT02342756 | University of Toronto | N/A |
| Completed | Time-motion-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in Emergency Depart NCT02273687 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Unknown | Strategies for Optimal Lung Ventilation in ECMO for ARDS: The SOLVE ARDS Study NCT01990456 | University of Toronto | N/A |
| Completed | Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) NCT02097641 | Michael A. Matthay | Phase 2 |
| Unknown | Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure NCT02112500 | Asan Medical Center | Phase 2 |
| Unknown | Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients NCT01992237 | Charite University, Berlin, Germany | — |
| Completed | Reproductibility of TM-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in the E NCT01743105 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Completed | Local Assessment of Ventilatory Management During General Anesthesia for Surgery NCT01601223 | European Society of Anaesthesiology | — |
| Unknown | Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Dist NCT01716962 | Chang Gung Memorial Hospital | — |
| Completed | Can Novel Oxygenation Indices Guide the Diagnosis of Acute Respiratory Distress Syndrome NCT06430619 | Başakşehir Çam & Sakura City Hospital | — |
| Completed | Pulmonary Pathophysiology and Inflammatory Response in Patients Treated With Ecmo for Severe Respiratory Failu NCT01468142 | Karolinska University Hospital | — |
| Completed | Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARD NCT02961166 | University Hospital Tuebingen | — |
| Unknown | Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome NCT01391481 | Chinese PLA General Hospital | Phase 2 |
| Terminated | INR-Triggered Transfusion In GI Bleeders From ER NCT01461889 | University of Colorado, Denver | Phase 3 |
| Completed | ART - Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial NCT01374022 | Hospital do Coracao | N/A |
| Completed | Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory D NCT01256333 | Rennes University Hospital | — |
| Completed | Changes in Refractory Acute Respiratory Distress Syndrome (ARDS) Patients Under High Frequency Oscillation-ven NCT01167621 | Centre Hospitalier Universitaire de la Réunion | — |
| Unknown | Inflammatory Effects of a Lung Recruitment Manoeuvre NCT01070654 | Azienda Ospedaliero, Universitaria Pisana | N/A |
| Terminated | Effect of Enteral Nutrition Support for Critically Ill Patients NCT01464853 | Abbott Nutrition | Phase 3 |
| Unknown | Adaptive Support Ventilation in Acute Respiratory Distress Syndrome (ARDS) NCT01165528 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Net NCT00542737 | Sunnybrook Health Sciences Centre | N/A |
| Terminated | Calfactant for Direct Acute Respiratory Distress Syndrome NCT00682500 | Pneuma Pharmaceuticals Incorporated | Phase 3 |
| Terminated | Continuous Positive Airway Pressure (CPAP) Ventilation Using a Novel Full-Face Mask Versus Conventional Helmet NCT00944437 | University of Parma | N/A |
| Completed | Early Insulin and Development of ARDS NCT00605696 | Albert Einstein College of Medicine | Phase 2 |
| Completed | Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Synd NCT00883948 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Terminated | Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People Wi NCT00609180 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Understanding the Role of Genes and Biomarkers in the Inflammation and Blood Clotting Process in Children With NCT00605527 | University of California, San Francisco | — |
| Completed | Evaluating Health Outcomes and QOL After ALI Among Participants of the ALTA, OMEGA, EDEN, and SAILS ARDS Netwo NCT00719446 | Johns Hopkins University | — |
| Completed | Viral-Related Neutrophil Response and Condition Severity in People With ARDS NCT00548795 | National Jewish Health | — |
| Terminated | Drug Study of Albuterol to Treat Acute Lung Injury NCT00434993 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 / Phase 3 |
| Completed | ARDSnet Protocol vs. Open Lung Approach in ARDS NCT00431158 | Massachusetts General Hospital | N/A |
| Completed | Comparison of Two Methods of High Frequency Oscillatory Ventilation in Individuals With Acute Respiratory Dist NCT00399581 | Johns Hopkins University | Phase 2 |
| Terminated | Weaning From Mechanical Ventilation Using Permissive Hypercarbia NCT00357929 | Milton S. Hershey Medical Center | N/A |
| Completed | Combined High Frequency Oscillation and Tracheal Gas Insufflation for Severe Acute Respiratory Distress Syndro NCT00416260 | University of Athens | Phase 1 / Phase 2 |
| Completed | Safety and Efficacy Study of Depelestat in Acute Respiratory Distress Syndrome (ARDS) Patients NCT00455767 | Debiopharm International SA | Phase 2 |
| Completed | A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) NCT00351533 | University of Washington | Phase 2 |
| Withdrawn | Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation NCT00308022 | University of Texas Southwestern Medical Center | Phase 2 / Phase 3 |
| Withdrawn | Role of Vascular Endothelial Growth Factor (VEGF) in Acute Lung Injury/Adult Respiratory Distress Syndrome (AR NCT00319631 | Weill Medical College of Cornell University | — |
| Completed | Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syn NCT00267241 | Policlinico Hospital | N/A |
| Completed | Effect of Positive Expiratory Pressure on Right Ventricular Function in Patients With Respiratory Distress Syn NCT00236262 | Assistance Publique - Hôpitaux de Paris | N/A |
| Terminated | IC14 Antibodies to Treat Individuals With Acute Lung Injury NCT00233207 | University of Washington | Phase 2 |
| Terminated | Activated Protein C to Treat Acute Lung Injuries NCT00112164 | University of California, San Francisco | Phase 2 |
| Unknown | Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients NCT00429637 | University of Virginia | — |
| Completed | Carbon Monoxide to Prevent Lung Inflammation NCT00094406 | National Institutes of Health Clinical Center (CC) | Phase 1 |
| Completed | Australia and New Zealand Adult Extracorporeal Membrane Oxygenation (ECMO) Audit 2005 NCT00157144 | Bayside Health | — |
| Completed | Long-Term Results in Mechanically Ventilated Individuals With Acute Lung Injury/Acute Respiratory Distress Syn NCT00300248 | Johns Hopkins University | — |
| Completed | Significance of Biological Markers in Patients With Acute Lung Injury/Acute Respiratory Disease NCT00217880 | University of Michigan | N/A |
| Completed | A Randomized Trial of GM-CSF in Patients With ALI/ARDS NCT00201409 | University of Michigan | Phase 2 |
| Completed | Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care NCT00458926 | Tufts Medical Center | — |
| Completed | Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Tran NCT00141726 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury NCT00113685 | University of Washington | N/A |
| Completed | Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome NCT01119872 | Hospital Universitario Principe de Asturias | N/A |
| Unknown | A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients NCT00465374 | University of Turin, Italy | Phase 3 |
| Completed | Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation NCT00029328 | FDA Office of Orphan Products Development | Phase 1 / Phase 2 |
| Completed | A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury NCT00036062 | Eli Lilly and Company | Phase 1 / Phase 2 |
| Completed | Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis NCT00004494 | Stony Brook University | Phase 1 |
| Completed | Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) NCT00000579 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |