NCT04508933

Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Istanbul University - Cerrahpasa · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Conditions

• Respiratory Distress Syndrome, Adult
• Ventilation Perfusion Mismatch
• Pulmonary Edema
• Covid19

Interventions

Type	Name	Description
DEVICE	Extravascular Lung Water Index	Measurement of the EVLWI
DEVICE	Pulmonary Vascular Permeability Index	Measurement of the PVPI

Timeline

• Start date: 2020-09-01
• Primary completion: 2020-09-30
• Completion: 2020-12-31
• First posted: 2020-08-11
• Last updated: 2021-10-26

Locations

1 site across 1 country: Turkey (Türkiye)

Regulatory

• FDA-regulated device study