NCT05715762

Determine the Effects of Prone Positioning and NO in COVID-19 ARDS by EIT

Determine the Effects of Prone Positioning and Nitric Oxide in Adult COVID-19 Patients With ARDS by Electrical Impedance Tomography

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.

Detailed description

The investigators aim to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography (EIT). The EIT assessment is performed in patients ventilated in supine position, supine position with NO inhalation for 1 hour, prone position for 1 hour, prone position for 2 hours with NO inhalation for 1 hour, prone position for 3 hours, prone position for 16 hours, re-supine position for 3 hours. Arterial blood gas (ABG) analysis results, ventilator parameters and hemodynamic parameters are also recorded at each time point.

Conditions

• Respiratory Distress Syndrome, Adult
• COVID-19

Interventions

Type	Name	Description
BEHAVIORAL	prone postion	ventilation at prone positioning
DRUG	NO inhalation	NO inhalation at 20 ppm

Timeline

• Start date: 2022-12-21
• Primary completion: 2023-06-30
• Completion: 2023-12-31
• First posted: 2023-02-08
• Last updated: 2023-02-08

Locations

1 site across 1 country: China