| Not Yet Recruiting | Evaluating Laser Otoscope for Middle Ear Effusion Detection NCT07454512 | MSTATT LLC | — |
| Not Yet Recruiting | Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young Children NCT07328555 | Boston Children's Hospital | N/A |
| Not Yet Recruiting | Validating and AI Software for Assessment of Children With Ear Concerns NCT07243093 | Glimpse Diagnostics, Inc. | — |
| Not Yet Recruiting | Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal NCT07189572 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 3 |
| Recruiting | Perspectives on Antibiotics and Tracking Symptoms in Children NCT07093749 | Murdoch Childrens Research Institute | N/A |
| Not Yet Recruiting | Post-Market Clinical Follow-Up Study of the Solo+ Tympanostomy Tube Device NCT07029997 | AventaMed DAC | — |
| Not Yet Recruiting | SWIR Otoscopy Study NCT06944795 | Stanford University | N/A |
| Active Not Recruiting | Digital Otoscope Versus Education and Feedback for Otitis Media in Young Children NCT06731660 | Boston Children's Hospital | N/A |
| Recruiting | Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Re NCT05915078 | Smith & Nephew, Inc. | — |
| Unknown | Stapes Footplate Thickness Measured With UHR-CT NCT05799404 | Central Hospital, Nancy, France | — |
| Unknown | Pneumococcal Carriage and Serotype Distribution in Children With Otitis Media in Malaysia. NCT05429541 | IMU University, Malaysia | — |
| Active Not Recruiting | In-Office Clinical Study of the Solo+ TTD NCT05741333 | AventaMed DAC | N/A |
| Active Not Recruiting | Diagnostic Utility of Otosight Middle Ear Scope NCT05641285 | Baylor College of Medicine | — |
| Completed | Broad Implementation of Outpatient Stewardship NCT05127161 | Children's Hospital of Philadelphia | N/A |
| Recruiting | Coherent Optical Detection of Middle Ear Disease NCT05353569 | Medical College of Wisconsin | N/A |
| Completed | Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Oti NCT04600752 | GlaxoSmithKline | Phase 4 |
| Recruiting | Effect of Chitodex Gel in Tympanoplasty Surgery NCT06260618 | Central Adelaide Local Health Network Incorporated | N/A |
| Unknown | Clinical Study of the Solo+ Tympanostomy Tube Device NCT04148417 | AventaMed DAC | N/A |
| Unknown | Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium NCT04447521 | Sciensano | — |
| Withdrawn | N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media NCT00956748 | St. Paul's Hospital, Canada | Phase 4 |
| Recruiting | Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion i NCT03655665 | Boston Children's Hospital | Phase 4 |
| Completed | Nasal Xylitol in the Prevention of Otitis Media NCT02592382 | Rambam Health Care Campus | N/A |
| Completed | Clinical Evaluation of the OtoSight NCT03890107 | PhotoniCare, Inc. | — |
| Completed | Hearing for Learning Initiative - a Health Facilitator Model for Otitis Media NCT03916029 | Menzies School of Health Research | N/A |
| Completed | Otogenic CSVT Retrospective Case Series and Associated Thrombophilia NCT03864055 | HaEmek Medical Center, Israel | — |
| Unknown | Clinical Study of the Solo Tympanostomy Tube Device NCT03722160 | AventaMed DAC | N/A |
| Completed | In-Office Study of the Hummingbird® in Children 6 Months-21 Years Old NCT03544138 | Preceptis Medical, Inc. | N/A |
| Completed | Antimicrobial Stewardship in Community Pharmacy NCT04219553 | University of Toronto | N/A |
| Completed | Video Discharge Instructions for Acute Otitis Media NCT02788422 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Evaluation of Moderate to Severe Influenza Outcomes in Children NCT02979626 | University of Colorado, Denver | — |
| Completed | Improving Knowledge Translation Upon Emergency Department Discharge NCT02703389 | Hamilton Health Sciences Corporation | Phase 3 |
| Unknown | Clinical Study of Solo Tympanostomy Tube Device (TTD) NCT02957578 | Nottingham University Hospitals NHS Trust | N/A |
| Completed | Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish Children NCT02742753 | GlaxoSmithKline | — |
| Terminated | A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea NCT02817347 | Yuhan Corporation | Phase 1 / Phase 2 |
| Terminated | The Effects of Ventilation Tubes - The SIUTIT Trial NCT02490332 | Zealand University Hospital | N/A |
| Completed | Study of the Hummingbird TTS™ Tympanostomy Tube System NCT03503591 | Preceptis Medical, Inc. | — |
| Completed | Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes NCT02600559 | Otonomy, Inc. | Phase 3 |
| Completed | Family MobilePhone Otoscopy in Diagnostics of Otitis Media NCT02452164 | Turku University Hospital | N/A |
| Unknown | Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol NCT02592096 | Lee's Pharmaceutical Limited | Phase 1 |
| Unknown | Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placeme NCT02653742 | Anica Crnkovic | Phase 4 |
| Terminated | Systematic Search for Primary Immunodeficiency in Adults With Infections NCT02972281 | University Hospital, Lille | N/A |
| Withdrawn | Pharmacokinetic Study of AL-60371 Otic Suspension in Pediatric Subjects Following Tympanostomy Tube Surgery NCT01908764 | Alcon Research | Phase 1 |
| Completed | Hummingbird TTS Ear Tube Delivery Study NCT02165384 | Preceptis Medical, Inc. | N/A |
| Completed | Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Year NCT01735084 | Menzies School of Health Research | Phase 4 |
| Withdrawn | Evaluation of a New Biocompatible Pressure Equalizing Tube NCT01775709 | University of California, Irvine | N/A |
| Completed | Earset Healthy Volunteer Study NCT01611246 | Integra LifeSciences Corporation | — |
| Completed | Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media NCT01588535 | Arbor Pharmaceuticals, Inc. | Phase 2 |
| Completed | Furlow Palatoplasty With Tensor Tenopexy NCT01535131 | University of Pittsburgh | N/A |
| Completed | Tympanostomy Tube Placement in Children in the Office (Inova Study) NCT01496287 | Integra LifeSciences Corporation | N/A |
| Unknown | Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Chil NCT01619462 | Papua New Guinea Institute of Medical Research | Phase 3 |
| Completed | inVENT-visIOn Study NCT01444391 | Integra LifeSciences Corporation | N/A |
| Completed | Pneumococcal Vaccines Early and in Combination NCT01174849 | Menzies School of Health Research | Phase 4 |
| Completed | Effect of Simethicone on Eustachian Tube Dysfunction NCT01312038 | University of Pittsburgh | Phase 2 |
| Completed | inVENT-In-Office Study NCT01324271 | Integra LifeSciences Corporation | N/A |
| Completed | The Impact of Ear Pain Anticipatory Guidance Counseling on Otitis Related Visits in a Low Income Population NCT02616458 | University of Colorado, Denver | N/A |
| Unknown | The Effect of Obesity on Ventilation Tube Insertion NCT01437436 | Soonchunhyang University Hospital | — |
| Completed | Effect of Prevnar 13 on Ear Infections in Children NCT01199016 | Pfizer | — |
| Completed | National Trends in Otitis Media in Children Under 5 Years of Age NCT01339546 | Pfizer | — |
| Completed | Acclarent Tympanostomy Tube Delivery System for the Treatment of Patients Requiring Tympanostomy Tube Insertio NCT02150044 | Integra LifeSciences Corporation | N/A |
| Completed | Homeopathic Ear Drops for Otitis Media Study NCT01003210 | University of Washington | N/A |
| Completed | Singapore Tympanostomy Tube Delivery System Study NCT01046877 | Integra LifeSciences Corporation | N/A |
| Completed | Study Evaluating Microbiological Analysis of Spontaneous Draining Acute Otitis Media NCT00768534 | Pfizer | — |
| Terminated | Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients NCT00778063 | Ochsner Health System | N/A |
| Completed | Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy NCT01244126 | Baylor College of Medicine | Phase 4 |
| Unknown | Host-pathogen Interaction in Otitis Media NCT00847756 | Radboud University Medical Center | — |
| Completed | Improving Otitis Media Care With Clinical Decision Support NCT00581711 | Children's Hospital of Philadelphia | Phase 3 |
| Completed | Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) NCT00419380 | University of Colorado, Denver | Phase 4 |
| Unknown | The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Chil NCT00393159 | Tel-Aviv Sourasky Medical Center | Phase 4 |
| Completed | Eustachian Tube Growth and Development NCT00422929 | University of Pittsburgh | — |
| Completed | Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media NCT00360100 | Pfizer | Phase 3 |
| Completed | A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media NCT00276042 | Replidyne | Phase 2 |
| Completed | Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media NCT00195611 | Wyeth is now a wholly owned subsidiary of Pfizer | — |
| Completed | ParentLink: Better and Safer Emergency Care for Children NCT00457600 | Boston Children's Hospital | — |
| Terminated | Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axet NCT00174811 | Sanofi | Phase 3 |
| Completed | Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea NCT00219401 | Papua New Guinea Institute of Medical Research | Phase 2 |
| Completed | Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections NCT04016051 | Grünenthal GmbH | Phase 3 |
| Completed | Wait and See Antibiotic Prescription for Acute Otitis Media: A Randomized Controlled Trial NCT00250900 | Yale University | N/A |
| Completed | A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children NCT00189462 | Deborah Gentile | Phase 4 |
| Completed | Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media NCT00638534 | Sanofi | Phase 3 |
| Completed | Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media NCT00051753 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of In NCT00044473 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children NCT00781521 | Daiichi Sankyo | Phase 3 |
| Completed | Genetics of Middle Ear Disease NCT00422136 | University of Pittsburgh | — |
| Completed | Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to NCT00365092 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | N/A |
| Unknown | Prevention Recurrent Otitis Media in the Young Children NCT00162994 | Oulu University Hospital | N/A |
| Completed | Maternal Immunization To Prevent Infant Otitis Media NCT00617682 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 1 / Phase 2 |
| Completed | Echinacea Purpurea and Osteopathy in Children With Recurrent Otitis Media NCT00689468 | University of Arizona | N/A |
| Completed | Vaccination for Middle Ear Infection NCT00001605 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 1 |
| Completed | Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children NCT00539149 | Menzies School of Health Research | Phase 4 |
| Completed | Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Medi NCT00378417 | Finnish Institute for Health and Welfare | Phase 3 |
| Completed | Acute Otitis Media: Adjuvant Therapy to Improve Outcome NCT00000363 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 3 |
| Unknown | The Influence of Feeding Position on Pulmonary Morbidity in Young Children NCT00248391 | Hadassah Medical Organization | N/A |
| Completed | Nervous System Manipulation and Botanicals for the Treatment of Recurrent Ear Infections in Children NCT00010465 | National Center for Complementary and Integrative Health (NCCIH) | Phase 2 |