NCT04447521

Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium

A 20-months Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium to Evaluate National Vaccination Strategy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 3,600 (estimated)
• Sponsor: Sciensano · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators will conduct a prospective observational study of non-invasive S. pneumoniae infections in Belgium and characterize serotype distributions to evaluate national vaccination programs.

Detailed description

The investigators will conduct a surveillance of non-invasive S. pneumoniae infections in Belgium (September 2020-May 2025). Monthly, 12 peripheral hospitals will send the first 15 unduplicated clinical S. pneumoniae samples (coming from patients diagnosed with pneumonia, otitits media or sinusitis) to the investigators. The investigators will determine the serotype and the antibiotic resistance profile of these clinical isolates. Whole genome sequencing will be performed on a subset of these isolates. From May 2021, 13 extra participating centers have been added to the study.

Conditions

• Pneumonia
• Otitis Media
• Sinusitis Bacterial

Timeline

• Start date: 2020-09-01
• Primary completion: 2025-05-01
• Completion: 2025-12-31
• First posted: 2020-06-25
• Last updated: 2022-10-27

Locations

1 site across 1 country: Belgium