| Recruiting | Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage NCT07294118 | The University of Texas Medical Branch, Galveston | Phase 2 |
| Unknown | A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders. NCT05995873 | MindLight, LLC | N/A |
| Withdrawn | Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder NCT03804619 | Stanford University | N/A |
| Completed | Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain NCT04156802 | Wake Forest University Health Sciences | N/A |
| Completed | The Effect of Self-Forgiveness on Self-Stigma in Addiction. NCT03971097 | University of Pittsburgh | N/A |
| Completed | Impact of Lofexidine on Stress, Craving and Opioid Use NCT03718065 | Medical University of South Carolina | Phase 2 |
| Completed | Remote Observed Dosing of Suboxone to Improve Clinical Practice NCT03769025 | University of Pennsylvania | Phase 1 / Phase 2 |
| Completed | Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent NCT03681769 | Medical University of South Carolina | EARLY_Phase 1 |
| Completed | Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET NCT03527485 | Yale University | N/A |
| Terminated | Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder NCT03538444 | Medical University of South Carolina | N/A |
| Completed | Cognitive Function Before and After Opioid Reduction in Patients With Chronic Pain NCT03036917 | Zealand University Hospital | — |
| Completed | A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic NCT03235154 | Community Research Initiative of New England | Phase 4 |
| Completed | Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting NCT03662529 | Hunter Holmes Mcguire Veteran Affairs Medical Center | N/A |
| Completed | Pilot Study of Contingency Management for Smoking Cessation NCT03015597 | King's College London | N/A |
| Completed | Medicinal Dependence and Chronic Pain: Addictive Evaluation in CETD NCT03635346 | University Hospital, Brest | — |
| Completed | Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose NCT02801357 | USWM, LLC (dba US WorldMeds) | Phase 1 |
| Completed | Outcomes of Opioid Addicted Prisoners With Extended-Release Injectable Naltrexone NCT02617628 | University of Pennsylvania | Phase 2 / Phase 3 |
| Completed | Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence NCT02602795 | Rhode Island Hospital | N/A |
| Completed | Study of Buprenorphine-Naloxone Sublingual Spray and Suboxone® Sublingual Film in Healthy Volunteers NCT02477267 | INSYS Therapeutics Inc | Phase 1 |
| Unknown | Substance Dependence Satisfaction With Care and Quality Of Life NCT02894476 | Central Hospital, Nancy, France | — |
| Completed | Clinical Efficacy and Serum Proteomic Profiling of Suan-Zao-Ren Tang for Sleep Disturbance During Methadone Ma NCT01913418 | China Medical University, Taiwan | Phase 2 |
| Completed | Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Depende NCT01848054 | Orexo AB | Phase 3 |
| Completed | Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone NCT01882361 | University of Pennsylvania | Phase 2 / Phase 3 |
| Completed | Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia NCT01863251 | Yale University | Phase 2 |
| Withdrawn | Naloxone Methadone Combination (NAMEKO) NCT01160432 | Kuopio University Hospital | N/A |
| Completed | Remote Observed Dosing to Increase Suboxone Compliance NCT01779973 | University of Pennsylvania | N/A |
| Unknown | Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and NCT02052258 | MacDonald, Kai, M.D. | Phase 1 |
| Completed | Variation of COMT Val158Met Polymorphism Between COM-ON Patients and METHADOSE Patients NCT01570699 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment NCT01802515 | Yale University | N/A |
| Completed | Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence NCT01690546 | Paolo Mannelli | Phase 2 |
| Completed | Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment NCT01376570 | Albert Einstein College of Medicine | N/A |
| Completed | Developing a Smoking Cessation Intervention for Methadone Maintained Smokers NCT01393392 | Rutgers, The State University of New Jersey | Phase 1 |
| Completed | Reengineering Methadone Treatment Study of Patient-centered Methadone Treatment NCT01442493 | Friends Research Institute, Inc. | N/A |
| Completed | Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia NCT01389167 | Yale University | Phase 3 |
| Withdrawn | Compliance Monitoring in Real Time During Opioid Substitution Treatment NCT01183130 | Kuopio University Hospital | N/A |
| Completed | The Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts NCT01512433 | China Medical University, Taiwan | N/A |
| Completed | Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment NCT01334580 | Yale University | Phase 1 |
| Completed | Behavioral Drug and HIV Risk Reduction Counseling With MMT in China NCT01389180 | Yale University | Phase 3 |
| Completed | Electronic Compliance Monitoring in Opioid Substitution Treatment NCT01182402 | Kuopio University Hospital | N/A |
| Completed | Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From Jail NCT01180647 | NYU Langone Health | Phase 3 |
| Completed | Clinical Trial of Integrated Treatment for Pain and Opioid Dependence NCT00634803 | Yale University | Phase 1 / Phase 2 |
| Completed | Linking Hospitalized Injection Drug Users to Buprenorphine NCT00987961 | Butler Hospital | Phase 3 |
| Completed | ALK21-021: A Safety Study of Medisorb® Naltrexone (VIVITROL®) Administered to Health Care Professionals NCT00834080 | Alkermes, Inc. | Phase 3 |
| Completed | Multicentre Trial of Suboxone in Opiate-dependent Subjects in Taiwan NCT00901875 | Indivior Inc. | Phase 4 |
| Completed | A Bridge to Treatment: The Therapeutic Workplace and Methadone Treatment NCT01416584 | Johns Hopkins University | N/A |
| Completed | Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence NCT00555425 | Yale University | Phase 4 |
| Completed | Entry Into Comprehensive Methadone Treatment Via Interim Maintenance NCT00712036 | Friends Research Institute, Inc. | N/A |
| Completed | ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence NCT00678418 | Alkermes, Inc. | Phase 3 |
| Completed | Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P0 NCT00725608 | Indivior Inc. | — |
| Completed | Employment-Based Depot Naltrexone Clinical Trial II NCT00684775 | Johns Hopkins University | Phase 2 |
| Unknown | Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction NCT00609089 | University of Cincinnati | Phase 1 / Phase 2 |
| Completed | Treatment of Opioid Dependent Patients With Suboxone: Acceptability & Safety Data From Real Life Scenario (Stu NCT00723749 | Indivior Inc. | — |
| Completed | A Randomized Acceptability and Safety Study of the Transfer From Subutex to Suboxone in Opioid- Dependent Subj NCT00605033 | Indivior Inc. | Phase 4 |
| Completed | A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED) NCT00604188 | Merck Sharp & Dohme LLC | Phase 4 |
| Completed | Behavioral Drug and HIV Risk Reduction Counseling in Methadone Patients in China NCT00757744 | Yale University | Phase 3 |
| Completed | Drug Counseling and Abstinent-Contingent Take-Home Buprenorphine in Malaysia NCT00539123 | Yale University | N/A |
| Completed | Cocaine Withdrawal and Pharmacotherapy Response NCT00566969 | Yale University | N/A |
| Completed | Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot NCT00577408 | New York State Psychiatric Institute | Phase 3 |
| Completed | Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients NCT00684073 | Indivior Inc. | Phase 4 |
| Completed | Observational Study of Misuse of High Dose Buprenorphine (Subutex® or Generic) in Opiate-Addicted Patients in NCT00723697 | Indivior Inc. | — |
| Completed | Effective Treatment of Hepatitis C in Substance Users NCT00633243 | Yale University | N/A |
| Completed | SSRI and Buprenorphine NCT00475878 | Butler Hospital | Phase 3 |
| Completed | Acceptance Therapy During Methadone Detoxification NCT00439036 | The University of Texas Health Science Center, Houston | Phase 1 |
| Terminated | Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8 NCT00218036 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | Reducing Sex-Related HIV Risk Behaviors in Patients Receiving Treatment for Opioid Dependence NCT00548275 | Yale University | Phase 2 |
| Completed | Prescription Opioid Addiction Treatment Study (POATS) NCT00316277 | Mclean Hospital | Phase 3 |
| Completed | Employment-Based Depot Naltrexone Clinical Trial NCT00684788 | Johns Hopkins University | Phase 2 |
| Completed | HEPMET-1: Evaluate the Feasibility, Mental Sideeffects and the Efficacy of Hepatitis C Treatment in a MMT Grou NCT00147784 | Sorlandet Hospital HF | Phase 3 |
| Completed | Naltrexone Implants as an Aid in Preventing Relapse Following Inpatient Treatment for Opioid Addiction NCT00521157 | University of Oslo | Phase 2 / Phase 3 |
| Completed | CRAFT Behavior Therapy: Treatment Entry Component NCT00842036 | Treatment Research Institute | Phase 2 |
| Completed | A Video-Based HCV Curriculum for Active Injection Drug Users NCT00241943 | Organization to Achieve Solutions in Substance Abuse (OASIS) | N/A |
| Completed | A Video-Based HCV Curriculum for Drug Users NCT00241917 | Organization to Achieve Solutions in Substance Abuse (OASIS) | N/A |
| Completed | Comparison of HIV Clinic-based Treatment With Buprenorphine Versus Referred Care in Heroin-dependent Participa NCT00130819 | Johns Hopkins University | Phase 2 |
| Recruiting | Substance Abuse Pre-Treatment Screening Study NCT00439049 | The University of Texas Health Science Center, Houston | — |
| Unknown | Integrating Buprenorphine Into HIV Treatment NCT00241930 | Organization to Achieve Solutions in Substance Abuse (OASIS) | Phase 4 |
| Completed | The Effects of Methadone and Buprenorphine on Fetal Neurobehavior and Infant Neonatal Abstinence Syndrome - 1 NCT00218621 | Johns Hopkins University | — |
| Completed | Counseling for Primary Care Office-based Buprenorphine NCT00595764 | Yale University | Phase 4 |
| Completed | The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration NCT00227357 | Ruth M. Rothstein CORE Center | — |
| Completed | Bone Density and Serum Testosterone in Male Methadone Maintained Patients NCT00170339 | Hennepin Healthcare Research Institute | — |
| Completed | Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1 NCT00129298 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Withdrawn | HIV Risk Reduction and Drug Abuse Treatment in Iran NCT00398008 | Yale University | Phase 2 |
| Completed | Brief Introductory Therapy for Opioid Dependence NCT00406484 | Yale University | Phase 2 |
| Terminated | ALK21-006EXT: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol- or Opioid-dependent Adults (Ext NCT00156936 | Alkermes, Inc. | Phase 3 |
| Completed | Prospective Cohort of Opiate Dependent Patients on Buprenorphine/Naloxone for Maintenance NCT00622596 | Yale University | N/A |
| Completed | Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers NCT00580827 | Yale University | N/A |
| Completed | HIV Risk Reduction and Drug Abuse Treatment in Malaysia NCT00383045 | Yale University | Phase 2 |
| Completed | Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia NCT00300794 | Vilnius University | Phase 4 |
| Completed | Treatment of Polydrug-Using Opiate Dependents During Withdrawal NCT00367874 | Sorlandet Hospital HF | Phase 4 |
| Completed | Behavioral Naltrexone Therapy: A Novel Treatment for Heroin Dependence NCT00332228 | New York State Psychiatric Institute | Phase 2 |
| Completed | ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids NCT01218984 | Alkermes, Inc. | Phase 2 |
| Completed | Determine the Safety of a Sublingual Tablet Formulation of Buprenorphine and Naloxone by Extending the Combina NCT00007527 | US Department of Veterans Affairs | Phase 4 |