NCT00367874

Treatment of Polydrug-Using Opiate Dependents During Withdrawal

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 12 (planned)
• Sponsor: Sorlandet Hospital HF · Other Government
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for long-term treatment. In our clinical practice we have felt the need for a standardised and safe detoxification treatment regimen for our opioid addicts, as dependence on multiple drugs is so common. Objectives 1. To assess whether a novel standardised treatment regimen - Buprenorphine (BPN) combined with Valproate (VPA) - will result in fewer withdrawal symptoms during detoxification of opiate-polydrug users than the existing treatment regimen, i.e. Clonidine (CLN) combined with Carbamazepine (CBZ). 2. To determine whether there are differences in treatment retention between the BPN/VPA and the CLN/CBZ groups. 3. To assess differences in clinical side-effects and biochemical interactions between the two treatment regimens.

Conditions

• Opiate Dependence
• Drug Dependence
• Substance Withdrawal Syndrome

Interventions

Type	Name	Description
DRUG	Buprenorphine
DRUG	Valproate

Timeline

• Start date: 2003-02-01
• Completion: 2003-11-01
• First posted: 2006-08-23
• Last updated: 2006-08-23

Locations

1 site across 1 country: Norway