| Active Not Recruiting | Central Sensitisation in Nociceptive and Neuropathic Pain NCT07321080 | IRCCS Centro Neurolesi Bonino Pulejo | — |
| Recruiting | Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population NCT07084935 | Radboud University Medical Center | — |
| Recruiting | Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia NCT06905340 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Recruiting | Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back Pain NCT06763653 | Presidio Medical, Inc | N/A |
| Recruiting | FDG PET/MR Imaging of Peripheral Pain Generators NCT06171659 | University of Wisconsin, Madison | — |
| Completed | NOL Index in Response to Pacemaker Stimulation NCT06696781 | Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu | — |
| Not Yet Recruiting | PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin NCT06599151 | Stanford University | Phase 1 |
| Completed | Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoske NCT06393088 | IR Technology, LLC | N/A |
| Recruiting | Cervical/Thoracic Neuromodulation and Nociceptive Processing NCT06367777 | Université Catholique de Louvain | N/A |
| Completed | Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health Outcomes NCT05837923 | Radicle Science | N/A |
| Completed | Intraoperative Electroencephalographic Biomarkers of Postoperative Pain NCT06313320 | University of Chile | — |
| Recruiting | Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury NCT06443281 | University of Zurich | — |
| Recruiting | Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception. NCT06291363 | Ciusss de L'Est de l'Île de Montréal | Phase 4 |
| Completed | Guiding Opioid Administration in Patients With Regional Anesthesia NCT06040307 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Comparison of the Skin Conductance Algesimeter and the Nociception Level Index in the Paediatric Population. A NCT05998564 | Radboud University Medical Center | — |
| Recruiting | Unveiling Physiological and Psychosocial Pain Components with an Artificial Intelligence Based Telemonitoring NCT06044584 | ETH Zurich | — |
| Completed | Pain Phenotypes in Patients With Fibromyalgia Syndrome NCT05941780 | Kutahya Health Sciences University | — |
| Unknown | Nociception Level Index (NOL Index) for Obstetrical Pain Assessment Under Epidural Analgesia. NCT05898737 | Centre Hospitalier Universitaire Saint Pierre | — |
| Unknown | Consciousness and Nociception During Anesthesia NCT05879731 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | — |
| Completed | Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection Pain NCT05049577 | Wonkwang University Hospital | N/A |
| Completed | Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes NCT05589935 | Radicle Science | N/A |
| Completed | Nociception and BIS Level Monitoring in COVID-19 Patients in the Intensive Care Unit NCT05579106 | Leiden University Medical Center | — |
| Unknown | The Impact of Esmolol Administration on Postoperative Recovery NCT05567822 | Aretaieion University Hospital | N/A |
| Suspended | Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care Unit NCT05399758 | University of Chile | — |
| Completed | Cervical Neuromodulation and Nociceptive Processing NCT05127200 | Université Catholique de Louvain | N/A |
| Unknown | The Nociception Level (NOL) Index for Pain Assessment in the Adult Intensive Care Unit NCT05339737 | McGill University | — |
| Completed | Comparison of Different Objective Nociceptive Measurement Methods During Surgery NCT05218551 | Göteborg University | — |
| Completed | PET/CT Guided Robotic Arm-assisted Pain Palliation in Chronic Nociceptive Low Backache NCT05560165 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Effect of ANI on Intraoperative Opioid Consumption NCT05106452 | Zonguldak Bulent Ecevit University | — |
| Unknown | Vitamin D Level and Pain Type in Coccygodynia NCT05047393 | Cumhuriyet University | — |
| Unknown | Clinical Trial Using Pupillometry to Measure Nociception in Healthy Volunteers. NCT04864340 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Cerebral and Autonomic Responses to Pain in Healthy Humans NCT04925336 | Hospices Civils de Lyon | N/A |
| Unknown | Guiding Sufentanil Administration With Skin Conductance in Mechanically Ventilated Intensive Care Patients NCT04696016 | Erasme University Hospital | N/A |
| Completed | PET/MRI in the Diagnosis of Pediatric Chronic Pain NCT04435821 | Stanford University | Phase 1 |
| Completed | Postoperative Benefits of Intraoperative Nociception Level (NOL) Titration - Pilot NCT04305015 | Medasense Biometrics Ltd | N/A |
| Unknown | CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve NCT04542798 | Hospital General Universitario de Valencia | N/A |
| Completed | NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane NCT04567160 | Ciusss de L'Est de l'Île de Montréal | Phase 4 |
| Unknown | Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor NCT05732896 | Turkish Society of Anesthesiology and Reanimation | N/A |
| Unknown | Pediatric Validation of CONOX Monitor During Surgery NCT04826146 | Patricio Gonzalez Pizarro | — |
| Completed | NIPE Monitoring Values During Routine Pediatric Anesthesia NCT04432480 | University Hospital, Lille | — |
| Completed | Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol NCT03841812 | China International Neuroscience Institution | Phase 3 |
| Completed | Nol-Index Guided Remifentanil Analgesia Versus Standard Analgesia During Moderate-to-High Risk Cardiovascular NCT04137991 | Erasme University Hospital | N/A |
| Completed | Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia NCT03912740 | Erasme University Hospital | N/A |
| Completed | Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fent NCT03858621 | Victor Contreras, MSN | N/A |
| Completed | The Correlation Between Sevoflurane and qNOX NCT03665792 | China International Neuroscience Institution | — |
| Completed | A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects NCT04154501 | Centrexion Therapeutics | Phase 1 |
| Completed | Intraoperative Nociception and Postoperative Pain NCT03761433 | Samsung Medical Center | — |
| Unknown | PET/MRI in the Diagnosis of Chronic Pain NCT03556137 | Stanford University | Phase 1 |
| Completed | The Prediction for Postoperative Pain NCT03585088 | Samsung Medical Center | N/A |
| Completed | Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia NCT03556696 | University Hospital, Lille | N/A |
| Unknown | The Effect of Ongoing Beta-blockers Administration on Analgesic Requirements in the Immediate Perioperative Pe NCT03498898 | Tel-Aviv Sourasky Medical Center | N/A |
| Terminated | Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype NCT03422783 | Ciusss de L'Est de l'Île de Montréal | N/A |
| Terminated | Evaluation of Medasense's PMD-200 During Surgery and Post Anesthesia Care NCT03276260 | Medasense Biometrics Ltd | — |
| Completed | Monitor-Guided Analgesia During General Anesthesia - Part II NCT03380949 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Monitor-Guided Analgesia During General Anesthesia - Part I NCT03303651 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope NCT03277872 | Ciusss de L'Est de l'Île de Montréal | N/A |
| Completed | A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics NCT03787004 | Centrexion Therapeutics | Phase 1 |
| Completed | Pain Assessment by Pupil Dilation Reflex (PDR) and Pupillary Pain Index (PPI) in Response to Noxious Stimulati NCT03140241 | University Hospital, Antwerp | N/A |
| Unknown | Translation of the Self Completed-Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale NCT02450565 | The University of Hong Kong | — |
| Unknown | Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain M NCT02485795 | Proove Bioscience, Inc. | — |
| Completed | Monitoring Analgesia by ANI (Analgesia The Nociception Index) NCT03749304 | University Hospital, Lille | N/A |
| Completed | Low Level Laser Therapy in the Dorsal Root Ganglion in the Treatment of Chronic Low Back Pain NCT02529670 | University of Nove de Julho | N/A |
| Withdrawn | Compounded Pain Creams and Patient Perception NCT02024802 | Marwood LowCost Pharmacy | — |
| Completed | The Post-operative Analgesia of the Virtual Reality Using a Mirror Therapy After Total Knee Arthroplasty NCT01979718 | Ulsan University Hospital | N/A |
| Completed | Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal an NCT01240148 | AstraZeneca | Phase 1 |
| Terminated | Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low B NCT00986258 | Grünenthal GmbH | Phase 3 |