NCT05567822

The Impact of Esmolol Administration on Postoperative Recovery

The Effect of Intraoperative Esmolol Administration on Postoperative Recovery and Chronic Pain

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Aretaieion University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Detailed description

Contemporary anaesthesiology requires the quest of ways to restrict the use of opioids, which aim at the alleviation of severe postoperative and chronic pain. This is not only due to the side effects involved but also to the epidemic dimensions their use entails. Esmolol, an extremely short-acting cardioselective antagonist of β1 adrenergic receptors, is effectively used in order to attenuate the stress response and minimize undesirable perioperative hemodynamic changes. More specifically, esmolol has been used effectively to reduce pain during induction of anesthesia with propofol and treat tachycardia and hypertension during laryngoscopy. However, recent studies also highlight a possible antinociceptive and/or analgesic effect of esmolol. Therefore, The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Conditions

• Pain, Acute
• Pain, Postoperative
• Pain, Chronic Post-Surgical
• Esmolol
• Inguinal Hernia Repair
• Analgesia
• Nociceptive Pain

Interventions

Type	Name	Description
DRUG	Esmolol Hydrochloride	In the esmolol group, patients will receive a bolus dose of esmolol followed by a continuous infusion of esmolol intraoperatively
DRUG	normal saline	In the placebo group, patients will receive a bolus dose of normal saline followed by a continuous infusion of normal saline intraoperatively

Timeline

• Start date: 2022-10-01
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2022-10-05
• Last updated: 2022-10-27

Locations

1 site across 1 country: Greece