NCT05049577

Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection Pain

Can Preanesthetic Analgesia/Nociception Index (ANI) Predict Propofol Injection Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 124 (actual)
• Sponsor: Wonkwang University Hospital · Academic / Other
• Sex: Male
• Age: 19 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Recently, Analgesia Nociception Index (ANI) has been evaluated for objectively measuring peri-operative pain and to guide intra-operative opioid administration during various surgeries. Propofol injection pain (PIP) is a common problem and can be very distressing to the patient.

Detailed description

This study aimed to the association of preanesthetic ANI scores and PIP in patients who scheduled for general anesthesia. Before propofol administration in remifentanil group, preanesthetic ANI values (instant and mean) were checked after remifentanil to a target Ce of 4 ng/ml. Control group received the same volume of saline as remifentanil group. Heart rate and bispectral index were checked as ANI. Point biserial correlation and ROC curve were analyzed.

Conditions

• Pain, Acute
• Analgesia
• Nociceptive Pain

Interventions

Type	Name	Description
DEVICE	Analgesia/Nociception Index (ANI)	V1 and V5 electrocardiographic positions as per the manufacturer's recommendations. The ANI was continuously recorded and displayed with a frequency of 1 Hz. ANI scores measured immediately before propofol administration, half-dose administration (1mg/kg), and full-dose administration (2mg/kg)of propofol.

Timeline

• Start date: 2023-04-01
• Primary completion: 2023-04-10
• Completion: 2023-06-30
• First posted: 2021-09-20
• Last updated: 2023-10-10

Locations

1 site across 1 country: South Korea