NCT03841812

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol Using Index of Nociception (NOX)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 146 (actual)
• Sponsor: China International Neuroscience Institution · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)

Detailed description

1. Recently study found sevoflurane plays an important role through spinal nerve peptide receptor (NK.1R), glycine receptor (GlyR), neuron nicotinic receptor (nnAChRs), Methyl-1-methyl-1-day aspartate (NMDA receptor), and TRPV1 receptor (TRPV1 receptor) produce the analgesic efficiency. 2. propofol was traditional sedation reagent. 3. index of Nociception (NOX) was the objective index for analgesia This study purpose to compare analgesia efficiency of Only Propofol and sevoflurane combine with propofol using index of Nociception (NOX)

Conditions

• Nociceptive Pain
• Analgesic Adverse Reaction
• Inhalant Use

Interventions

Type	Name	Description
DRUG	5mg/kg/h Propofol	5mg/kg/h Propofol continuously infused during intre-operation
DRUG	Sevoflurane	1% Sevoflurane continuously using during intre-operation.
DRUG	2 mg/kg/h Propofol	2mg/kg/h Propofol continuously infused during intre-operation

Timeline

• Start date: 2020-01-20
• Primary completion: 2020-06-01
• Completion: 2020-07-01
• First posted: 2019-02-15
• Last updated: 2020-10-14

Locations

1 site across 1 country: China