| Not Yet Recruiting | Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE) NCT07462637 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD) NCT07111390 | NYU Langone Health | N/A |
| Recruiting | Personalized Ultrasonic Brain Stimulation for Depression (R61) NCT06902298 | Brian Mickey | Phase 1 / Phase 2 |
| Recruiting | The Impact of Coach-guided Risk Communication on the Risk of Major Depression NCT06619366 | Dalhousie University | N/A |
| Recruiting | Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents NCT06523439 | University of Texas at Austin | N/A |
| Recruiting | Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study NCT06732089 | Unity Health Toronto | — |
| Recruiting | Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients NCT06508710 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | At-Home tDCS as Maintenance Therapy NCT07269964 | Technical University of Munich | N/A |
| Completed | A Text Messaging Intervention to Reduce Perinatal Depression Risk NCT06117397 | University of Massachusetts, Worcester | N/A |
| Terminated | SAINT for MDD in an Inpatient Setting Follow-on NCT06462820 | Magnus Medical | Phase 2 / Phase 3 |
| Terminated | The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition NCT03693105 | Magnus Medical | Phase 2 / Phase 3 |
| Recruiting | Metabolomics During ElectroConvulsivoTherapy NCT05973643 | Hôpital le Vinatier | N/A |
| Recruiting | Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics NCT04130958 | Massachusetts General Hospital | N/A |
| Recruiting | Presynaptic Imaging in Major Depressive Episodes After COVID-19 NCT06086366 | Centre for Addiction and Mental Health | — |
| Completed | The RAFT ECT Study NCT05402657 | The George Institute | N/A |
| Recruiting | Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psy NCT05866991 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Microglial Activation in Inflammatory Bowel Disease NCT03487926 | Centre for Addiction and Mental Health | — |
| Completed | Personalized Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Episode NCT05465928 | Jiangsu Province Nanjing Brain Hospital | N/A |
| Active Not Recruiting | Personalized Ultrasonic Brain Stimulation for Depression NCT05301036 | University of Utah | Phase 1 / Phase 2 |
| Completed | Mobile Observation Of Depression NCT05815459 | Emteq Ltd | — |
| Terminated | Antidepressant Efficacy of Psychotherapy and Citalopram in Patients With Breast Cancer and Major Depression NCT05063604 | Hospital Universitari de Bellvitge | Phase 2 |
| Unknown | Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Treatment for Major Depressive NCT05498441 | Jiangsu Province Nanjing Brain Hospital | N/A |
| Completed | Affective Touch, Hedonia and Suicidal Behavior NCT05182827 | University Hospital, Montpellier | N/A |
| Unknown | Left vs. Right Non-Inferiority Trial NCT04999553 | University of British Columbia | N/A |
| Recruiting | Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety NCT05028738 | University of British Columbia | N/A |
| Recruiting | Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive E NCT03646058 | Centre Hospitalier Universitaire de Nīmes | Phase 3 |
| Completed | Ketamine As an Adjunctive Therapy for Major Depression (2) NCT04939649 | University of Dublin, Trinity College | Phase 3 |
| Completed | Neuroinflammation in COVID-19 and Depression NCT04854785 | Centre for Addiction and Mental Health | — |
| Unknown | The Effects of Anger and Joy Expressions on Approach and Avoidance Behaviors in Healthy Volunteers NCT04899609 | University Hospital, Montpellier | — |
| Recruiting | Reward Processing and Depressive Subtypes: Identifying Neural Biotypes NCT06080646 | San Francisco Veterans Affairs Medical Center | — |
| Completed | Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep NCT04832750 | University of Oldenburg | — |
| Unknown | Assessement of Capacity to Consent NCT04740463 | University Hospital, Montpellier | — |
| Recruiting | University of Iowa Interventional Psychiatry Service Patient Registry NCT04480918 | Mark Niciu | — |
| Completed | Predict MDE Outcomes After MST NCT03841019 | Shanghai Mental Health Center | N/A |
| Completed | Terrorist Attack - Continuity of Care NCT03770156 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Stud NCT04086316 | Freie Universität Berlin | — |
| Recruiting | Comparing Uni- and Bi-lateral TBS in Major Depression NCT04142996 | The Royal Ottawa Mental Health Centre | N/A |
| Completed | Validation Study: Mobile DSST on Cognition in Adults With MDD NCT03999567 | Brain and Cognition Discovery Foundation | N/A |
| Withdrawn | Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression NCT03833063 | Helse Stavanger HF | Phase 1 |
| Completed | Stress Systems and Psychotherapy in Depression NCT03752853 | Freie Universität Berlin | N/A |
| Completed | Universal vs. Targeted School Screening for Adolescent Major Depressive Disorder NCT03716869 | Milton S. Hershey Medical Center | N/A |
| Completed | A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive Episod NCT03692910 | Biogen | Phase 2 |
| Active Not Recruiting | Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder NCT03336918 | Brigham and Women's Hospital | — |
| Completed | The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation NCT03190772 | Philipps University Marburg | N/A |
| Completed | Cognitive Behavioural Therapy for the Treatment of Late Life Depression NCT03735576 | University of Cologne | N/A |
| Completed | Ketamine as an Adjunctive Therapy for Major Depression NCT03256162 | St Patrick's Hospital, Ireland | Phase 1 |
| Completed | Medibio DDA Confirmatory Performance Study NCT03529513 | Medibio Limited | — |
| Unknown | Investigation of Antidepressant Efficacy of Oral Ketamine Treatment NCT02992496 | Medical University of Vienna | Phase 2 |
| Completed | ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) NCT03113968 | Bo Hu | Phase 2 / Phase 3 |
| Terminated | NeoSync TMS Treatment for Bipolar I Depression NCT02839798 | Butler Hospital | Phase 2 |
| Unknown | Neuroinflammation, Serotonin, Impulsivity and Suicide NCT02824081 | University Hospital, Montpellier | N/A |
| Terminated | Pain Perception in Suicidal Behavior Vulnerability NCT02915679 | University Hospital, Montpellier | N/A |
| Completed | Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN) NCT02051413 | Institut National de la Santé Et de la Recherche Médicale, France | Phase 4 |
| Completed | Retrospective Observational Study DIANA Study NCT01976793 | AstraZeneca | — |
| Completed | Ketamine for Suicidality in Bipolar Depression NCT01944293 | New York State Psychiatric Institute | Phase 1 / Phase 2 |
| Terminated | MRS and Medication Response: A Pilot Study NCT03254342 | Stanford University | — |
| Unknown | Computerized Cognitive Remediation for Geriatric Depression NCT01979289 | Weill Medical College of Cornell University | N/A |
| Completed | Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adul NCT01869374 | New York State Psychiatric Institute | Phase 1 / Phase 2 |
| Terminated | Study of Functional Networks in Resting fMRI NCT03323073 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | A Study of Ketamine as an Antidepressant NCT01441505 | The University of New South Wales | Phase 2 |
| Terminated | Antidepressants to Promote Recovery of Cardiac Patients Suffering From Depression NCT01099592 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 4 |
| Completed | Major Depression and Messenger RNAs NCT00998231 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | N-3 Polyunsaturated Fatty Acids in the Prevention and Treatment for IFN-induced Depression NCT01620502 | National Science and Technology Council, Taiwan | N/A |
| Completed | Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled NCT00852592 | Northwestern University | Phase 3 |
| Completed | Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT) NCT00680433 | Northside Clinic, Australia | Phase 4 |
| Completed | Predictors of the Response and Relapse/Recurrence After ECT for Depressed Patients NCT02032576 | Kaohsiung Kai-Suan Psychiatric Hospital | Phase 4 |
| Completed | Open-Label Study of Geodon in Non-Rapid Cycling Bipolar II Patients With Major Depression NCT00237666 | The Medical Research Network | Phase 4 |