NCT02824081

Neuroinflammation, Serotonin, Impulsivity and Suicide

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 280 (estimated)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Suicide is a major health problem that causes annually a million death worlwide. In the stress-vulnerability model, suicidal behavior (SB) results from the interaction between an individual's predisposition (personality, family history of SB…) and stressful conditions (early life adversity). Studies show that suicide ideations could favour inflammation and that depression is associated with an elevated inflammation. Recent evidences also suggest that inflammatory mediators play a critical role in SB. The aim of the study is to evaluate the inflammatory markers rate on depressed patients with or without personal history of SB. In the second part of the study, the relations between the rates of inflammatory markers and characteristics of SB, impulsivity, psychological pain, childhood abuse and gene expression of 5HT2B receptor will be investigated.

Detailed description

Over one year, we will recruit 280 patients suffering from a major depressive episode with (n=140) and without any history of suicide attempt (n=140), from a specialized clinic for mood disorders and SB. First visit : clinical, biological and neuropsychological assessment Second visit, at 6 month : Follow-up visit in the department or interview by telephone in order to assess suicidal ideations or suicide attempts since the inclusion.

Conditions

• Major Depressive Episode
• Suicidal Behavior

Interventions

Type	Name	Description
BIOLOGICAL	Blood sample	Blood sample in order to study inflammatory biomarkers and genetics purpose

Timeline

• Start date: 2015-11-01
• Primary completion: 2017-05-01
• Completion: 2017-11-01
• First posted: 2016-07-06
• Last updated: 2016-07-06

Locations

1 site across 1 country: France