Trials / Recruiting
RecruitingNCT04130958
Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- Sponsor
- Massachusetts General Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive episode (MDE) or borderline personality disorder (BPD).
Detailed description
This neuroimaging study aims to determine the effectiveness of iTBS-TMS to the IPL in reducing suicide risk in patients with MDE or BPD. This study also aims to identify the structural and functional circuit properties that characterized the suicidal brain and the signatures that explain the clinical severity of suicidal risk. Moreover, this study aims to determine biological and dimensional predictors of anti-suicidal response to iTBS-TMS and its mechanism of action.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Intermittent Theta Burst Transcranial Magnetic Stimulation (Active) | iTBS-TMS is a noninvasive neuromodulation technique that uses a powerful magnet to induce focal electrical currents in target brain regions. |
| DEVICE | Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham) | The sham version of iTBS-TMS involves placing the magnet over the same target brain region but the device will not be turned on during the treatment. There will be two electrodes placed on the scalp that mimic the sensation of iTBS-TMS but does not induce focal electrical currents. |
Timeline
- Start date
- 2023-11-01
- Primary completion
- 2026-04-30
- Completion
- 2026-04-30
- First posted
- 2019-10-18
- Last updated
- 2025-06-12
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT04130958. Inclusion in this directory is not an endorsement.