| Not Yet Recruiting | A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lym NCT07500506 | Pfizer | Phase 3 |
| Not Yet Recruiting | Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy NCT06542289 | Neurotrigger Ltd | N/A |
| Not Yet Recruiting | Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-b NCT06859619 | University Hospital, Montpellier | N/A |
| Recruiting | Borrelia B-cell Diagnostics NCT06045416 | University Children's Hospital, Zurich | — |
| Recruiting | Navigating Pregnancy and Parenthood With Lyme Disease NCT06397794 | Children's National Research Institute | — |
| Withdrawn | Evaluation and Follow-up of People With Tick-borne Diseases NCT04318925 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | A Study to Evaluate the Safety and Immunogenicity of mRNA-1975 and mRNA-1982 Against Lyme Disease in Participa NCT05975099 | ModernaTX, Inc. | Phase 1 / Phase 2 |
| Recruiting | Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure NCT06026969 | Children's National Research Institute | — |
| Completed | Perceptions,Social Representations and Experience of Lyme Borreliosis and Ticks in Adolescents Likely to be In NCT05678478 | Centre Hospitalier Intercommunal Creteil | — |
| Completed | Safety Study of a Vaccine to Help Protect Against Lyme Disease in Healthy Children NCT05634811 | Pfizer | Phase 3 |
| Active Not Recruiting | An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based NCT05477524 | Pfizer | Phase 3 |
| Recruiting | Human Immune Response to Ixodes Scapularis Tick Bites NCT05036707 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Enrolling By Invitation | Quest to Analyze One Thousand Humans Meditating NCT06583395 | Tobias Moeller-Bertram | — |
| Completed | Feasibility of Teleyoga for Treatment of Lyme Disease NCT04867473 | Stanford University | N/A |
| Unknown | Direct Diagnosis of Disseminated Lyme Borreliosis. NCT04719962 | University Hospital, Strasbourg, France | N/A |
| Unknown | The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Coho NCT05312619 | Dr. Daniel Cameron & Associates | — |
| Unknown | Lyme Disease Diagnostic Assay - Collection of Whole Blood NCT05041595 | DiaSorin Inc. | — |
| Unknown | Biomarker Study of Previously Treated Lyme Disease Volunteers in Comparison to Healthy Volunteers NCT04835792 | FlightPath Biosciences, Inc. | — |
| Completed | First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disea NCT04863287 | MassBiologics | Phase 1 |
| Terminated | PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics NCT04577053 | Kasey Phifer | N/A |
| Recruiting | Rheumatology Patient Registry and Biorepository NCT04402086 | Yale University | — |
| Completed | ImmuneSense Lyme Study NCT04422314 | Adaptive Biotechnologies | — |
| Withdrawn | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease NCT04148222 | ProgenaBiome | — |
| Terminated | Symptomatic Management of Lyme Arthritis NCT04038346 | Desiree Neville, MD | Phase 3 |
| Unknown | Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children NCT03981874 | Centre Hospitalier Universitaire de Besancon | N/A |
| Unknown | Novel Diagnostics for Early Lyme Disease NCT03963635 | MicroB-plex, Inc. | — |
| Suspended | Lyme Disease Patients With Memory Problems NCT03500770 | Spaulding Rehabilitation Hospital | N/A |
| Completed | Comparison of IFA and LIAISON® for Diagnosis of Early Disseminated Lyme Borreliosis in Children, Younger Than NCT03798704 | University Medical Centre Ljubljana | — |
| Completed | Next Generation Sequencing Detection of Lyme Disease NCT03505879 | Stony Brook University | — |
| Unknown | Understanding Tick-borne Diseases NCT03501407 | Institut Pasteur | — |
| Terminated | Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel NCT03581279 | T2 Biosystems | N/A |
| Terminated | Lyme Test Indication Combinations (LyTIC) Study NCT03201042 | Oxford Immunotec | — |
| Terminated | CD8 Reactivity to Microorganisms in Blood and Breast Milk NCT03084614 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Terminated | A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Dis NCT02741609 | Advanced Laboratory Services, Inc. | N/A |
| Completed | Xenodiagnosis After Antibiotic Treatment for Lyme Disease NCT02446626 | National Institute of Allergy and Infectious Diseases (NIAID) | N/A |
| Recruiting | Central Nervous System Infections in Denmark NCT03418441 | Aalborg University Hospital | — |
| Completed | Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice NCT01368341 | Morten Lindbaek | Phase 4 |
| Completed | Searching for Persistence of Infection in Lyme Disease NCT01143558 | National Institute of Allergy and Infectious Diseases (NIAID) | EARLY_Phase 1 |
| Completed | Persistent Lyme Empiric Antibiotic Study Europe NCT01207739 | Radboud University Medical Center | Phase 4 |
| Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford NCT01793168 | Sanford Health | — |
| Completed | Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation NCT01243008 | University of Zurich | Phase 1 / Phase 2 |
| Terminated | Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes NCT00958139 | University of Minnesota | Phase 3 |
| Completed | Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis NCT04653558 | University Medical Centre Ljubljana | — |
| Completed | Tick-borne Encephalitis and Possible Borrelial Serology NCT03958058 | University Medical Centre Ljubljana | — |
| Completed | Erythema Migrans in Elderly NCT03371563 | University Medical Centre Ljubljana | — |
| Completed | A School-Based Intervention to Reduce Lyme Disease NCT00594997 | Brigham and Women's Hospital | N/A |
| Recruiting | Evaluation, Treatment, and Follow-up of Patients With Lyme Disease NCT00028080 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Brain Imaging and Retreatment Study of Persistent Lyme Disease NCT00037479 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 |
| Completed | Lyme Disease Prevention Program NCT00000432 | Brigham and Women's Hospital | Phase 3 |
| Recruiting | A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatme NCT00001539 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Study and Treatment of Post Lyme Disease (STOP-LD) NCT00000937 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone an NCT00001101 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone an NCT00000938 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |