| Not Yet Recruiting | Jaw Muscle Pain Post Wisdom Molar Surgery NCT07094542 | Rutgers, The State University of New Jersey | Phase 2 |
| Not Yet Recruiting | Lidocaine Patch and Lower Third Molar NCT07330726 | Fayoum University | Phase 3 |
| Not Yet Recruiting | Local Metformin Gel and Impacted Lower Third Molar NCT06975839 | Fayoum University | Phase 2 |
| Completed | Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Spli NCT07436546 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Recruiting | Variability in Analgesic Response to Ibuprofen NCT06539741 | University of Pennsylvania | — |
| Recruiting | Assessment of Vertical Pattern in Correlation With Third Molar Inclusion : A 3D CBCT Analysis NCT06320665 | Central Hospital, Nancy, France | — |
| Active Not Recruiting | Pain Control Following Third Molar Surgery NCT06514222 | University of Sharjah | EARLY_Phase 1 |
| Completed | Does Extraction Difficulty of Mandibular Impacted Third Molars Mirror Post-op Outcomes? NCT05049382 | Selcuk University | N/A |
| Not Yet Recruiting | Fracture Pattern Following Bilateral Sagittal Split Osteotomy With or Without Impacted Third Molars NCT06338982 | Kimie Bols Østergaard | N/A |
| Completed | Perineural and Systemic Dexamethasone Use in Dental Surgeries in Terms of Anesthesia Duration and Postop Compl NCT06318013 | Karamanoğlu Mehmetbey University | — |
| Unknown | Gum Health Gel in Post Extraction Sockets NCT06251141 | University of Baghdad | N/A |
| Recruiting | The Impact of 3D-CBCT Imaging on Nerve Injuries During Wisdom Tooth Surgery NCT06261853 | University of Aberdeen | N/A |
| Completed | Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar S NCT06262945 | Beste Erismen | — |
| Completed | Investigation of the Effects of H-PRF on the Period After Impacted Third Molar Tooth Extraction NCT06244797 | esengul sen | N/A |
| Completed | Risk Factors for Distal Caries of Second Molars Adjacent to Mandibular Impacted Third Molars NCT06017570 | Selcuk University | N/A |
| Completed | Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery NCT06900894 | Mustafa Kemal University | N/A |
| Completed | The Frequency of Trigeminocardiac Reflex During the Extraction of Impacted Mandibular Wisdom Teeth NCT06499532 | Kutahya Health Sciences University | N/A |
| Completed | The Effectiveness of Laser Acupuncture and Standard Medication Therapy on Mandibular Post-Odontectomy Patients NCT06023524 | Indonesia University | N/A |
| Unknown | Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets NCT06318247 | The Dental Hospital of Zhejiang University School of Medicine | N/A |
| Completed | Adjunctive Kinesiotaping in Surgical Treatment of Impacted Mandibular Third Molars NCT07333963 | Medical University of Silesia | N/A |
| Suspended | An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery NCT04874675 | University of Zimbabwe | N/A |
| Unknown | Use of Erbium Laser for Extraction of the Third Molars NCT05540015 | I.M. Sechenov First Moscow State Medical University | N/A |
| Completed | Post-Surgical Morbidity and Bone Healing of Impacted Lower Third Molars: Piezosurgery vs. Conventional Instrum NCT06262841 | Ankara University | N/A |
| Active Not Recruiting | Chlorhexidine Plus Hyaluronic Acid Mouthwash in Surgical Wound Healing Following Third Molar Surgery NCT05414253 | University of Pisa | N/A |
| Unknown | Comparison of Two Flaps in Surgical Removal of Impacted Lower Third Molar NCT05385679 | Ashutosh Kumar Singh | N/A |
| Completed | Evalution of the Effects of PRP and LLLT on Postoperative Complications and Wound Healing After Impacted Third NCT06836570 | Yuzuncu Yil University | N/A |
| Unknown | Assessment of Bone Density in Impacted Mandibular Third Molar NCT05944939 | Dow University of Health Sciences | N/A |
| Completed | Should Preoperative Information Before Impacted Third Molar Extraction? NCT05548790 | Ankara Yildirim Beyazıt University | N/A |
| Completed | Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar NCT06144983 | University of Baghdad | Phase 4 |
| Unknown | the Relationship Between Various Clinical Variables and Surgical Difficulty of Patients Have Impacted Lower Th NCT05320744 | University of Baghdad | — |
| Unknown | Accuracy of Variables for Impacted Mandibular Third Molar Surgery NCT05143359 | Dow University of Health Sciences | N/A |
| Completed | Piezosurgery and Conventional Rotary Instruments on Third Molar Surgery NCT05545553 | Marmara University | N/A |
| Completed | Effects of Photobiomodulation Conditioning in Impacted Third Molars NCT05344222 | University of Nove de Julho | N/A |
| Completed | the Effect of Ozone Oil on the Postoperative Sequalae After Surgical Removal of Third Molar NCT05544539 | University of Baghdad | Phase 2 |
| Completed | Effect of Modified Kinesio Taping Technique on Morbidity After Impacted Third Molar NCT04740450 | Fayoum University | N/A |
| Completed | Effect of Using Irrigations at Different Temperatures on Postoperative Period During the Extraction of Impacte NCT06020053 | Firat University | N/A |
| Unknown | Comparison of the Efficacy of I-Prf Impregnated Collagen and L-Prf on Healing After Impacted Third Molar Surge NCT05563519 | Yuzuncu Yil University | N/A |
| Completed | Effect of Honey and Dexamethason on Extraction Healing NCT04848259 | Al-Azhar University | EARLY_Phase 1 |
| Completed | The Need Of Root Canal Treatment After Coronectomy In Mandibular Third Molars NCT05744882 | Altamash Institute of Dental Medicine | N/A |
| Completed | Impact of 3D Intraoral Scanning on Postsurgical Evaluation of Mandibular Third Molar Surgery NCT05684601 | University of Catania | N/A |
| Completed | 3D Evaluation of Facial Swelling Post Impacted Lower Third Molars Surgery: RCT NCT05488028 | Azienda Ospedaliera Universitaria Policlinico "G. Martino" | N/A |
| Unknown | Dexamethasone Effect on Pain and Edema Following Mandibular 3rd Molar Surgery; Pre-operatively vs Post-operati NCT04319978 | Dow University of Health Sciences | Phase 4 |
| Completed | The Effect of Melatonin Application Following Removal of Impacted Third Molar NCT04424875 | Fayoum University | Phase 3 |
| Unknown | Evaluation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in the Healing of Post-extraction Sites NCT04438434 | University of Milan | Phase 3 |
| Unknown | Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery NCT04366635 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Completed | Evaluation of the Effects of Silk and Polyester Suture on Postoperative Complications NCT05534204 | Yuzuncu Yil University | N/A |
| Unknown | Different Oral Doses of Clindamycin in Preventing Post-operative Sequelae of Lower Third Molar Surgery NCT05268835 | Oral and Maxillofacial Surgery Clinic, Poland | Phase 4 |
| Completed | Evaluation of the Efficacy of Polybutester Suture on Postoperative Complications in Lower Impacted Third Molar NCT05679973 | Yuzuncu Yil University | N/A |
| Completed | Comparison of The Surgical Drain Placement With Use of Kinesiologic Tape NCT04108559 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Completed | Assessing a New Jaw Support Device During Third Molar Extractions NCT03975920 | University of Minnesota | N/A |
| Completed | Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction NCT03893175 | University of Pennsylvania | Phase 1 |
| Completed | COMPARISON OF PIEZOSURGERY AND CONVENTIONAL ROTARY INSTRUMENTS IN IMPACTED THIRD MOLAR SURGERY NCT03857035 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Unknown | Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations NCT04376268 | Yuzuncu Yil University | Phase 4 |
| Unknown | Evaluation of the Effects of Pre-operative Deflazacort on Post-operative Pain, Edema and Trismus NCT04365088 | Yuzuncu Yil University | Phase 4 |
| Completed | Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus NCT04534426 | Abant Izzet Baysal University | Phase 4 |
| Completed | Articaine and Bupivacaine in Impacted Tooth Surgery NCT04645888 | Kocaeli University | N/A |
| Completed | Comparison of Two Different Flap Designs for Bilateral Impacted Mandibular Third Molar Surgery NCT03784638 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Completed | Verbal and Visual Information Techniques on Anxiety in Third Molar Surgery NCT03752255 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Completed | Assessment of the Relationship Between Edema Measurement Methods After Impacted Mandibular Third Molar Surgery NCT03747237 | Konya Necmettin Erbakan Üniversitesi | N/A |
| Unknown | Evaluation of the Effects of Irrigation of the Extraction Socket With Rifamycine NCT04349579 | Yuzuncu Yil University | Phase 4 |
| Unknown | Clinical Efficacy of a New Piezoelectric Technique for Wisdom Teeth Extraction NCT03619460 | Azienda Ospedaliera di Bolzano | N/A |
| Completed | The Effect of Saline Irrigation at Different Temperatures on Pain, Edema, and Trismus After Impacted Third Mol NCT05170516 | Trakya University | N/A |
| Unknown | Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery NCT03741894 | University of Pecs | Phase 4 |
| Completed | Effect of St. John's Wort and Olive Oils on the Postoperative Complications NCT04373421 | Yuzuncu Yil University | Phase 4 |
| Completed | Feasibility Testing of a New Way to Support the Jaw During 3rd Molar Extractions NCT03512769 | University of Minnesota | — |
| Unknown | Computer Guided Versus Conventional Surgical Removal of Deeply Impacted Mandibular Third Molar With Preservati NCT03447067 | Alaadden Mahmoud Abu Al Enein | N/A |
| Completed | Conventional Coronectomy vs Coronectomy in Combination Vital Pulp Treatment Using Calcium Silicate NCT05882162 | zeynep cukurova yilmaz | N/A |
| Completed | Effect of Manual Massage Technique on Swelling, Pain and Mouth Opening After Bilateral Lower Third Molar Surge NCT06787027 | Izmir Katip Celebi University | N/A |
| Completed | Comparing OHRQoL: One or Two Sessions for Wisdom Teeth Removal NCT05820867 | Marmara University | N/A |
| Completed | Topical Hydrocortisone for Pain and Edema Control After Third Molar Surgery NCT03179813 | University of Sao Paulo | Phase 4 |
| Completed | Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery NCT04769557 | Melaka Manipal Medical College | Phase 4 |
| Unknown | Extraction of Impacted 3rd Molars, Can Bone Support of the Second Molar be Promoted by a Bio-Oss Graft? NCT02753439 | The Baruch Padeh Medical Center, Poriya | N/A |
| Completed | EFFICACY OF ICE PACK THERAPY AFTER IMPACTED THIRD MOLAR SURGERY NCT03261869 | Baskent University | N/A |
| Completed | Effects of Polyvinylpyrrolidone Iodine on Postoperative Trismus and Swelling During Impacted Third Molar Surge NCT03894722 | Cansu Gül Koca | Phase 4 |
| Unknown | Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries NCT03169127 | University of Sao Paulo | Phase 4 |
| Unknown | Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome NCT02951676 | The University of Hong Kong | — |
| Completed | Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery NCT02837614 | Sun Yat-sen University | EARLY_Phase 1 |
| Completed | Effectiveness of Platelet Rich Plasma in Wound Healing NCT02831374 | Linyi People's Hospital | EARLY_Phase 1 |
| Completed | Epidemiological Study on the Surgical Removal of Third Molars NCT02481700 | Universitaire Ziekenhuizen KU Leuven | — |
| Unknown | Changes in Resistome After Dental Extraction and Amoxicillin. NCT02830347 | The University of Hong Kong | — |
| Unknown | Clinical Validation of a Novel Classification for Predicting Surgical Complexity in Mandibular Wisdom Teeth Su NCT02519426 | Lithuanian University of Health Sciences | — |
| Unknown | Comparison of the Use of Dexamethasone and Diclofenac Sodium in Immediate Post-Operative Care in Third Molar S NCT02698306 | Hospital Geral de Vila Penteado | N/A |
| Completed | Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Remo NCT02494856 | Giovana Maria Weckwerth | Phase 4 |
| Completed | Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction. NCT02547896 | University of Sao Paulo | Phase 4 |
| Completed | Three Anxiolytic Drugs Used in Third Molar Surgery NCT02065843 | Universidade Federal de Sergipe | Phase 2 / Phase 3 |
| Completed | Dexamethasone in Lower Third Molar Surgery NCT02416869 | University of Belgrade | Phase 4 |
| Completed | Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar NCT02450487 | University of Sao Paulo | Phase 4 |
| Completed | Trapezoidal Flap vs. Envelope Flap in Mandibular Third Molar Extraction. NCT02120131 | University of Firenze and Siena, Napoli, Italy | — |
| Completed | Anxiety Control by Erythrina Mulungu NCT01948622 | Liane Maciel de Almeida Souza | Phase 1 / Phase 2 |
| Completed | Lower Third Molar Removal With 2% and 4% Articaine NCT02457325 | University of Sao Paulo | Phase 4 |
| Unknown | Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model NCT01429935 | Qazvin University Of Medical Sciences | Phase 2 |