NCT04874675

An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery

A Randomised Control Clinical Trial Comparing Diclofenac / Acetaminophen /Codeine and Ibuprofen/Acetaminophen/Codeine Combination for Pain Management After Third Molars Surgery

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: University of Zimbabwe · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Randomised control clinical trial to compare which combination of analgesics in effective in pain management after third molar extraction of wisdom teeth. The study will assess post operative pain after third molar extraction of two groups of study participants who will be given one of the two combinations of Diclofenac/ acetaminophen/codeine and ibuprofen/acetaminophen/codeine .

Detailed description

Double blind randomized control clinical trial to compare the level of pain relief that occurs after third molar extraction done under local anaesthesia at the maxillofacial center, Harare, Zimbabwe. The participants will be randomized into two arms upon fitting the inclusion criteria.The pharmacist will be in charge of randomization and will randomise the participants upon giving them the medications. One group will receive combination of diclofenac/acetaminophen/codeine and the other group will receive ibuprofen/acetaminophen/codeine as post extraction analgesia.The dosages of the medications will be Diclofenac 50mg, ibuprofen 400mg, acetaminophen 500mg and codeine 15mg respectively. Questionnaires will be given to the patient to complete after discharge from the surgery and other parts of the questionnaire will be completed on review after 7 days. A record will be done of the postoperative pain experience (using visual analogue scale), use of rescue medication and details pertaining to impacted tooth.

Conditions

• Impacted Third Molar Tooth
• PAIN

Interventions

Type	Name	Description
DRUG	diclofenac / acetaminophen /codeine	routine pain medication used post extraction of third molars
DRUG	ibuprofen/acetaminophen/codeine	routine pain medication used post extraction of third molars

Timeline

• Start date: 2023-03-01
• Primary completion: 2023-12-01
• Completion: 2024-04-01
• First posted: 2021-05-06
• Last updated: 2023-01-05

Locations

1 site across 1 country: Zimbabwe