NCT03741894

Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Pecs · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

In the everyday clinical practice the incidence of minor complications is approximately 15-20% of the total number of third molar removals. Alveolitis (dry socket syndrome) may arise in 30-40% of the surgical tooth removals. Several preventive approaches are known, such as the use of iodoform gauze, zink-oxide eugenol paste, platelet rich fibrin (PRF), different medicine containing pastes, like antibiotics containing, non-steroid pain killer containing, steroid containing, or the application of chlorhexidine gel and solutions. In the case of a manifest alveolitis these methods can be used as well. The aims of this research are: i) to identify the important pathogens which play role in the development of alveolitis (microbiological methods), ii) to analyze the in vitro effectivity of the different antiseptic materials in case of infections (inhibitory zones) iii) to compare the effectivity of different alveolitis preventive methods in a prospective clinical study, iv) to compare the different treatment options in alveolitis in a prospective clinical study.

Conditions

• Alveolitis of Jaw
• Alveoli, Teeth; Inflammation
• Dry Socket
• Impacted Third Molar Tooth

Interventions

Type	Name	Description
DRUG	Iodoform	Patients get iodoform (1000 grams containing 350 grams of iodoform, 300 grams of glycerin and 350 grams of alcohol 96%) soaked gauze (steril selvedge gauze bandage 2 cm x 5 m in appropriate length) drainage during suture placements for a week.
OTHER	Wound closure using sutures	Routine primary wound closure with single interrupted sutures (Surgilon 3-0 non-absorbable) only.
DRUG	Chlorhexidine	Extraction sockets are filled with 1% chlorhexidine gel (Curasept ADS310, Sager Pharma, Sager Dental Kft.,Budapest, Hungary) before suture (Surgilon 3-0 non-absorbable) placements.

Timeline

• Start date: 2018-09-01
• Primary completion: 2020-09-30
• Completion: 2021-09-30
• First posted: 2018-11-15
• Last updated: 2018-11-15

Locations

1 site across 1 country: Hungary