| Recruiting | Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituita NCT07273630 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis NCT06821802 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia NCT06020495 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelin NCT06781710 | University of Cologne | — |
| Not Yet Recruiting | Saline Infusion Test in Hyponatremia NCT06498856 | University Hospital, Akershus | — |
| Unknown | Low-dose Tolvaptan for Inpatient Hyponatraemia. NCT06171100 | King's College Hospital NHS Trust | — |
| Completed | Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD NCT06277336 | University Hospital, Basel, Switzerland | N/A |
| Completed | Mortality and Neurologic Outcomes in Rapid vs. Slow Hyponatremia Correction NCT06675591 | Hospital Italiano de Buenos Aires | — |
| Active Not Recruiting | Hyponatremia Volume Status Analysis by Point-of-care Ultrasound NCT06013800 | Universidad Veracruzana | — |
| Unknown | Plasma Sodium and Sodium Administration in the ICU NCT06037928 | University Hospital, Linkoeping | — |
| Active Not Recruiting | Hyponatremia - Complications, Prognosis, Epidemiology in Finnish Tertiary Care NCT07430787 | University of Turku | — |
| Recruiting | Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges NCT06408077 | University of Cologne | N/A |
| Completed | Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery NCT06484608 | Rawalpindi Medical College | N/A |
| Unknown | Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium NCT02709031 | Navitas Pharma | Phase 1 / Phase 2 |
| Completed | Retrospective Analysis of ECG Changes and Arrhythmias in Patients With Profound Hyponatremia NCT07255833 | University of Cologne | — |
| Completed | Delirium Related to Proton Pump Inhibitors Use NCT05815550 | University Hospital, Caen | — |
| Terminated | Urea for Chronic Hyponatremia NCT04588207 | Helbert Rondon Berrios, MD, MS | Phase 2 |
| Completed | Analysis of Factors Determining Increase of Serum Sodium in Hyponatremic Patients NCT05277584 | University of Cologne | — |
| Recruiting | Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia NCT04447911 | University Hospital, Basel, Switzerland | Phase 4 |
| Active Not Recruiting | Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage NCT04552873 | University Hospital, Grenoble | N/A |
| Unknown | Efficacy and Safety of Bolus Comparing With Continuous Drip of 3% NaCl in Patients With Severe Symptomatic Hyp NCT04561531 | Department of Medical Services Ministry of Public Health of Thailand | N/A |
| Completed | HYPONATREMIA IN COVID-19 PATIENTS NCT04493268 | Hospital Nacional Profesor Alejandro Posadas | — |
| Completed | Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients NCT04227301 | University Hospital, Basel, Switzerland | — |
| Terminated | Impact of Hyponatremia on Muscle Strength, Gait and Cognitive Function NCT04020926 | Bürgerspital Solothurn | — |
| Completed | Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia NCT04744987 | Hospital San Carlos, Madrid | — |
| Completed | Hyponatremia Due to Poly Ethylene Glycol (PEG) NCT03787888 | Tazeen Rasheed | — |
| Terminated | Colloid Osmotic Pressure and Osmolality in Hyponatremia NCT03703713 | University Hospital, Linkoeping | — |
| Completed | Targeted Correction of Plasma Sodium Levels in Hospitalized Patients With Hyponatremia NCT03557957 | University Hospital, Basel, Switzerland | N/A |
| Completed | Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status NCT04402190 | A.O.U. Città della Salute e della Scienza | — |
| Completed | Seizures in Infants Hospitalized in Pediatric Intensive Care Unit for Bronchiolitis NCT04022486 | Hospices Civils de Lyon | — |
| Completed | Early Sodium Intake in Preterm Newborns NCT04035564 | Hospital del Niño "Dr. Federico Gomez Santos" | Phase 4 |
| Completed | Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study NCT03202667 | University Hospital, Basel, Switzerland | Phase 2 / Phase 3 |
| Completed | The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy. NCT03371199 | Rigshospitalet, Denmark | N/A |
| Completed | Beer for Endurance Exercise Recovery NCT03032445 | State University of New York - Upstate Medical University | N/A |
| Completed | Intravenous Fluids in Hospitalised Children NCT02926989 | University of Oulu | Phase 4 |
| Terminated | Tolvaptan for Advanced or Refractory Heart Failure NCT02959411 | University of Calgary | Phase 4 |
| Unknown | Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children NCT02936167 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Completed | Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery) NCT03636568 | Washington University School of Medicine | N/A |
| Withdrawn | Protein Supplementation in Thiazide-induced Hyponatremia NCT02614807 | Ottawa Hospital Research Institute | N/A |
| Unknown | Regional Tolvaptan Registry NCT02666651 | Cardiology Research UBC | Phase 4 |
| Terminated | An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Participants With Euv NCT02020278 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | Post-Operative Water Load Following Transsphenoidal Pituitary Surgery NCT02727686 | St. Joseph's Hospital and Medical Center, Phoenix | N/A |
| Unknown | Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation. NCT06109532 | Hospital Nacional Profesor Alejandro Posadas | — |
| Completed | An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in S NCT02548845 | Otsuka Pharmaceutical Europe Ltd | — |
| Unknown | Factors Associated With Hyponatremia Induced by High-dose Cyclophosphamide NCT02399358 | Diego Hernan Giunta, MD | — |
| Completed | An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due NCT02545101 | Otsuka Pharmaceutical Europe Ltd | — |
| Withdrawn | A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia NCT02442674 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in It NCT02573077 | Otsuka Pharmaceutical Europe Ltd | — |
| Terminated | Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hyp NCT02012959 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Terminated | Tolvaptan for Patients With Acute Neurological Injuries NCT02545114 | Polderman, Kees, H., MD, PhD | N/A |
| Unknown | Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: NCT02432157 | Thomas Jefferson University | Phase 1 / Phase 2 |
| Completed | Hyponatremia in the Prevention of Hospitalized Patients Falls NCT03265691 | Mª del Carmen Lobo Rodríguez | N/A |
| Completed | Fluid Tonicity and Hyponatraemia Post Surgery NCT03840629 | National University Hospital, Singapore | — |
| Terminated | Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients NCT02215148 | University of North Carolina, Chapel Hill | — |
| Withdrawn | Reexamining Hypotonic Intravenous Fluid Use NCT02667977 | Ann & Robert H Lurie Children's Hospital of Chicago | N/A |
| Completed | Influence of Triathlon on the Electrolyte Balance NCT02263586 | University Hospital of Cologne | — |
| Completed | Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia. NCT02242604 | Volker Burst | — |
| Completed | Relationship Between Heat Wave and Hyponatremia NCT02012660 | University Hospital, Geneva | — |
| Completed | Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia NCT01909336 | Instituto Tecnologico y de Estudios Superiores de Monterey | Phase 3 |
| Completed | Effects of Oral Salt Supplementation on Physical Performance During a Half-ironman NCT02103491 | Camilo Jose Cela University | N/A |
| Completed | Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery NCT02765061 | Ankara University | — |
| Completed | Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia NCT01838759 | Zonguldak Bulent Ecevit University | — |
| Completed | Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia NCT01850940 | Beijing Friendship Hospital | — |
| Unknown | Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites NCT01716611 | Konkuk University Medical Center | Phase 4 |
| Unknown | The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia NCT01748331 | Finn Gustafsson | N/A |
| Terminated | Hyponatremia and Myometrium Contractility. An Invitro Study NCT01708811 | Karolinska University Hospital | — |
| Completed | Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia NCT01879774 | University of Cologne | N/A |
| Terminated | Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia NCT01890694 | NYU Langone Health | Phase 4 |
| Terminated | A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric NCT01451411 | Cumberland Pharmaceuticals | Phase 3 |
| Unknown | The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia NCT01509170 | Hadassah Medical Organization | — |
| Completed | Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients NCT01456533 | University Hospital, Basel, Switzerland | — |
| Withdrawn | Frequency and Origin of Dysnatremias in the Emergency Department NCT01326429 | Insel Gruppe AG, University Hospital Bern | — |
| Terminated | Tolvaptan for In-hospital Hyponatremia NCT01386372 | Mario Negri Institute for Pharmacological Research | Phase 2 |
| Completed | V2 Receptor Effects on Fluid Regulation and Performance NCT02084797 | Oakland University | N/A |
| Completed | Effect of Tolvaptan on Cognitive Function in Cirrhosis NCT01556646 | Hunter Holmes Mcguire Veteran Affairs Medical Center | Phase 3 |
| Completed | 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children NCT01301274 | Hospital General de Niños Pedro de Elizalde | N/A |
| Unknown | Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference St NCT04409626 | Zealand University Hospital | — |
| Completed | Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy? NCT01212211 | University Hospital, Caen | N/A |
| Completed | Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children NCT01251770 | Hospital General de Niños Pedro de Elizalde | Phase 3 |
| Terminated | Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia NCT01227512 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS NCT01299779 | Thomas Jefferson University | N/A |
| Completed | Post Operative Hyponatremia in the Renal Transplant Population NCT01456832 | Mayo Clinic | — |
| Completed | Study to Compare Conivaptan Pharmacokinetics in Subjects With Mild & Moderate Kidney Function Impairment to Su NCT00887627 | Cumberland Pharmaceuticals | Phase 1 |
| Terminated | Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure NCT00843986 | Cumberland Pharmaceuticals | Phase 3 |
| Completed | Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Live NCT00851227 | Cumberland Pharmaceuticals | Phase 1 |
| Completed | Tolvaptan Versus Fluid Restriction in SIADH NCT04119206 | University of Erlangen-Nürnberg Medical School | — |
| Terminated | Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients NCT00727090 | Northwestern University | Phase 4 |
| Completed | Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Trans NCT00839358 | Hospital Clinic of Barcelona | Phase 4 |
| Completed | Pico-Salax Colonic Preparation Study: Quantifying Electrolyte and Volume Status Changes NCT00885430 | Queen's University | Phase 4 |
| Terminated | A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional NCT00728091 | Sanofi | Phase 3 |
| Withdrawn | Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients NCT00684164 | Columbia University | Phase 3 |
| Unknown | Postoperative Hyponatremia - Are There Gender Differences? NCT00636857 | Karolinska University Hospital | N/A |
| Completed | Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial NCT00734214 | Hamilton Health Sciences Corporation | Phase 3 |
| Completed | Subclassification of the Syndrome of Inappropriate ADH Secretion NCT01341665 | University of Wuerzburg | — |
| Completed | Hypertonic Saline Solution in Heart Failure NCT00555685 | University of Sao Paulo | Phase 2 |
| Completed | 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children NCT00632775 | The Hospital for Sick Children | Phase 3 |
| Completed | Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly NCT00550459 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | Establishment of an Algorithm for a Clinical Classfication of Hypoosmolar Hyponatremia NCT00541944 | University of Wuerzburg | — |
| Completed | Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic NCT00478192 | Cumberland Pharmaceuticals | Phase 3 |
| Completed | A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia NCT00435591 | Cumberland Pharmaceuticals | Phase 4 |
| Completed | THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluati NCT00578695 | CardioKine Inc. | Phase 3 |
| Completed | Institutional Registry of Hyponatremia NCT01370473 | Hospital Italiano de Buenos Aires | — |
| Completed | Maintenance Intravenous Fluids in Children NCT00621348 | All India Institute of Medical Sciences | Phase 3 |
| Completed | Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion NCT00264914 | Sanofi | Phase 3 |
| Completed | Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion NCT00264927 | Sanofi | Phase 3 |
| Completed | International, Multicenter, Study of One-year, Open-label, Titrated Oral Tolvaptan Tablet Administration in Pa NCT02449044 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia NCT00379847 | Cumberland Pharmaceuticals | Phase 3 |
| Completed | "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia NCT00201994 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 3 |
| Completed | Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion NCT00032734 | Sanofi | Phase 2 |
| Completed | Water Load Test Value for Hyponatremia NCT04256499 | European Georges Pompidou Hospital | — |
| Completed | Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia NCT00380575 | Cumberland Pharmaceuticals | Phase 3 |
| Completed | Study of Efficacy & Safety of Oral YM087 in Subjects With Euvolemic or Hypervolemic Hyponatremia NCT00492037 | Cumberland Pharmaceuticals | Phase 3 |