NCT01748331

The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia

The Significance of the Vasopressin System of the Hemodynamics, Water Balance and Prognosis in Chronic Heart Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Finn Gustafsson · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia. The hypothesis is that strict fluid restriction leads to a larger increase in plasma sodium than standard treatment in patients with decompensated heart failure associated with hyponatremia. A secondary hypothesis is that the neurohormonal change is greater in patients treated with strict fluid restriction versus standard treatment.

Conditions

• Heart Failure
• Hyponatremia

Interventions

Type	Name	Description
OTHER	Fluid restriction	Patients will be randomized to strict fluid restriction \< 1 L/day versus moderate fluid restriction \< 2.5 L/day

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-11-01
• Completion: 2016-11-01
• First posted: 2012-12-12
• Last updated: 2015-10-28

Locations

2 sites across 1 country: Denmark