| Not Yet Recruiting | Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity NCT07263399 | Blekinge Institute of Technology | N/A |
| Completed | Can Atelectasis Be Prevented With Oxygen Reserve Index (ORI) Monitoring? NCT07050719 | Antalya Training and Research Hospital | N/A |
| Completed | The Association Between Sensory Block Level, Oxygen Therapy, and ORi in Varicose Vein Patients Undergoing Spin NCT06566690 | Kocaeli University | — |
| Completed | Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer Surgery NCT06989346 | Parc de Salut Mar | — |
| Suspended | Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-O NCT05923853 | Ohio State University | N/A |
| Completed | The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric Patients NCT06326372 | Tepecik Training and Research Hospital | — |
| Recruiting | Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL). NCT05412810 | Ohio State University | — |
| Completed | Oximeters and Skin Pigment: Impact of Skin Pigmentation on Accuracy of Pulse Oximetry NCT05690269 | University of Cincinnati | — |
| Completed | Oxygen Reserve Index and Prevention of Hyperoxemia NCT05505032 | Baskent University Ankara Hospital | Phase 4 |
| Completed | NICU Oxygen Control Study NCT04269161 | University of Missouri-Columbia | N/A |
| Unknown | Clinical Impact of Automated Oxygen Administration on Confirmed or Suspected COVID-19 in the Emergency Departm NCT05235386 | Laval University | — |
| Completed | Supplemental Oxygen in Hypovolemia NCT05150418 | Oslo University Hospital | Phase 1 |
| Active Not Recruiting | Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants NCT04413097 | Sharp HealthCare | N/A |
| Completed | Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care Unit NCT04879290 | University Hospital, Caen | N/A |
| Completed | The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit. NCT05807815 | Tepecik Training and Research Hospital | N/A |
| Completed | Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty Surgery NCT07158073 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | N/A |
| Completed | Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers NCT05099523 | Zonguldak Bulent Ecevit University | N/A |
| Completed | Different Preoxygenation Methods In Cesarean Section NCT05395975 | Zonguldak Bulent Ecevit University | — |
| Completed | Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. Nellcor NCT04866342 | University of Edinburgh | N/A |
| Completed | Retrospective Multicentre Observational Study on the Incidence of Hyperoxia in Non-intubated Patients in Inten NCT04291911 | SIZ Nursing | — |
| Completed | The Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia. NCT05770583 | Tepecik Training and Research Hospital | N/A |
| Terminated | SCO2T (Servo vs. Servo) NCT04546568 | University of Edinburgh | N/A |
| Completed | Can Hyperoxia be Prevented With Noninvasive Monitoring in On-pump Cardiac Surgery? NCT04753554 | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | N/A |
| Completed | The Effect of Intraoperative Arterial Oxygen Pressures on Early Post-Operative Patient and Graft Survival in L NCT04420897 | Akdeniz University | — |
| Completed | Hyperoxia and Pulmonary Complications After Cardiac Surgery NCT04278066 | University Hospital, Strasbourg, France | — |
| Enrolling By Invitation | The Effect of Respiratory Challenge on the BOLD Signal NCT04258774 | Washington University School of Medicine | N/A |
| Completed | Measuring Oxygenation of Newborn Infants in Targeted Oxygen Ranges NCT03360292 | University of Edinburgh | N/A |
| Completed | Servo Controlled Oxygen Targeting Study NCT04177992 | University of Edinburgh | N/A |
| Unknown | Conservative Versus Conventional Oxygen Administration in Critically Ill Patients NCT04198077 | University of Modena and Reggio Emilia | Phase 4 |
| Completed | Assessment of Oxygenation With Oxygen Reserve Index for General Anesthesia NCT04698863 | Zonguldak Bulent Ecevit University | — |
| Terminated | Comparison of Oxygen Controllers in Preterm InfanTs NCT03877198 | Leiden University Medical Center | N/A |
| Terminated | Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop NCT03835741 | Laval University | N/A |
| Completed | Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD NCT03661086 | Hvidovre University Hospital | N/A |
| Terminated | Computer-assisted Oxygen Therapy Weaning in Critically Ill Children NCT03550469 | Stanford University | N/A |
| Unknown | Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study NCT04133740 | Aalborg University Hospital | Phase 4 |
| Completed | Correlation of Changes in PaO2 and ORi in Adult Patients NCT03488238 | Masimo Corporation | — |
| Completed | Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD NCT03464695 | Hvidovre University Hospital | N/A |
| Completed | The Effect of Hyperoxia on Cardiac Output NCT03930979 | Frisius Medisch Centrum | — |
| Unknown | Intraoperative Hyperoxia and MINS NCT04540276 | University Hospital Bispebjerg and Frederiksberg | — |
| Completed | Neuroimaging During Pure Oxygen Breathing NCT03268590 | Case Western Reserve University | Phase 4 |
| Completed | Perioperative Hyperoxia vs Normoxia Biomarker Trial NCT07525661 | Istanbul University | N/A |
| Unknown | Individualized Perioperative Open-lung Ventilatory Strategy With High Versus Conventional Inspiratory Oxygen F NCT02776046 | Fundación para la Investigación del Hospital Clínico de Valencia | N/A |
| Withdrawn | The Effect of Decreasing the Inspired Oxygen Concentration on Post-Operative Oxygenation After Primary Lobecto NCT02509182 | Yale University | Phase 4 |
| Completed | Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients NCT02917668 | Laval University | N/A |
| Completed | Intelligent Oxygen Therapy During Activities of Daily Living NCT02683486 | Imperial College London | N/A |
| Completed | Hyperbaric Oxygen Therapy Effects on Pulmonary Functions NCT03754985 | Assaf-Harofeh Medical Center | — |
| Completed | Safe Limits in Saturation (SLIM-study) NCT02666937 | Amsterdam UMC, location VUmc | — |
| Unknown | Proteomics for Identification of Hyperoxia-induced Changes in Protein Expression NCT02553668 | University Hospital of Cologne | N/A |
| Unknown | Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery NCT02591589 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients NCT05354648 | Federal Research Clinical Center of Federal Medical & Biological Agency, Russia | N/A |
| Completed | Hyperoxygenation in Anesthetized Children NCT02384616 | Walid HABRE | N/A |
| Unknown | Intrinsic Periodic Pattern of Breathing NCT02201875 | Association pour la Recherche en Physiologie de l'Environnement | — |
| Completed | Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α NCT01978158 | Radboud University Medical Center | Phase 1 / Phase 2 |
| Completed | Effects of Oxygen Status on Hypoxia Inducible Factor 1-α and Inflammation. A Pilot Proof of Principle Study. NCT01889823 | Radboud University Medical Center | Phase 1 |
| Unknown | Intermittent Normoxia Reduces Myocardial Reperfusion Injury NCT01348906 | Central South University | N/A |
| Terminated | Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care NCT00887731 | University of Utah | — |
| Completed | Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Pa NCT00658853 | Norwegian University of Science and Technology | N/A |