NCT02509182

The Effect of Decreasing the Inspired Oxygen Concentration on Post-Operative Oxygenation After Primary Lobectomy

The Effect of Decreasing the Inspired Oxygen Concentration on Post-Operative Oxygenation After Primary Lobectomy: A Randomized Controlled Trial

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test the hypothesis that decreasing the inspired oxygen concentration during thoracic surgery requiring one lung ventilation will improve post-operative oxygenation.

Detailed description

One lung ventilation is frequently required during thoracic surgery and results in decreased lung function post-operatively. Supra-physiologic oxygen levels during surgery may contribute to this decrease in lung function by worsening lung injury intra-operatively. This study will include patients undergoing surgery to remove a lung lobe requiring one lung ventilation. The patients will be divided into two groups with the experimental group receiving a 60% oxygen in air mixture and the control group receiving 100% oxygen. The two groups will be compared by using a measure of lung function (the ratio of the partial pressure of oxygen in arterial blood to the inspired oxygen concentration) and blood levels of a protein correlated with lung injury (receptor of advanced glycation end products RAGE).

Conditions

• Hyperoxia

Interventions

Type	Name	Description
DRUG	60% oxygen	An inspired oxygen concentration of 60% will be administered during pulmonary lobectomy surgery.
DRUG	100% oxygen	An inspired oxygen concentration of 100% will be administered during pulmonary lobectomy surgery.

Timeline

• Start date: 2016-12-01
• Primary completion: 2017-07-01
• Completion: 2018-07-01
• First posted: 2015-07-27
• Last updated: 2018-01-12

Locations

1 site across 1 country: United States