NCT04879290

Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care Unit

Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care Unit : a Monocentric Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to assess the optimal fraction of inspired oxygen (0.5 or 1) for extubation or removal of a supraglottic airway device after general anesthesia.

Detailed description

During pre-anesthesia visit, eligible patients receive oral and written information of the study and potential risks. In the operating room all patients giving a written informed consent will undergo at the end of surgery a screening to determine eligibility for study entry. Before emergence from general anesthesia, patients who meet the eligibility requirements will be randomized in a open label manner to receive a 0.5 or 1 FiO2.

Conditions

• Anesthesia
• Atelectasis
• Postoperative Complications
• Hypoxemia
• Hyperoxia

Interventions

Type	Name	Description
OTHER	FiO2 0.5	Ten minutes before emergence from general anesthesia, the amount of oxygen delivered from the mechanical ventilator called fractional inspired oxygen (FiO2) is set to 0.5 (50%)
OTHER	FiO2 1	Ten minutes before emergence from general anesthesia, the amount of oxygen delivered from the mechanical ventilator called fractional inspired oxygen (FiO2) is set to 1 (100%)

Timeline

• Start date: 2021-04-09
• Primary completion: 2021-08-16
• Completion: 2021-08-16
• First posted: 2021-05-10
• Last updated: 2026-04-02

Locations

1 site across 1 country: France