NCT01889823

Effects of Oxygen Status on Hypoxia Inducible Factor 1-α and Inflammation. A Pilot Proof of Principle Study.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

It has been shown in in vitro and animal models that hypoxia can have pro-inflammatory effects and hyperoxia can have anti-inflammatory effects. The pro-inflammatory effect could be the result of activation of Hypoxia Inducible Factor, a transcription factor that is known to activate many cell systems aimed at cell survival, including the inflammatory response. The anti-inflammatory effects of hyperoxia could be the annihilation of Hypoxia Inducible Factor, but also a decrease in inflammation due to oxygen toxicity resulting in a decrease in clearance of pathogens. These effects have been sparsely studied in humans. Therefore, we hypothesize that hypoxia results in an increase in Hypoxia Inducible Factor in circulating leukocytes and increases inflammatory reactions, whereas hyperoxia decreases these reactions.

Conditions

• Hypoxia
• Hyperoxia

Interventions

Type	Name	Description
OTHER	Hypoxia	Subjects will be breathing an individualized mix of nitrogen and room air titrated to an oxygen saturation of 80-85%.
OTHER	Hyperoxia	Subjects will be breathing 100% oxygen

Timeline

• Start date: 2013-06-01
• Primary completion: 2013-08-01
• Completion: 2014-12-01
• First posted: 2013-06-28
• Last updated: 2015-03-25

Locations

1 site across 1 country: Netherlands