| Recruiting | Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI Therapy NCT07291700 | Bayer | — |
| Recruiting | Treatment of Gastroesophageal Reflux Disease in Infants NCT06255886 | Odense University Hospital | Phase 4 |
| Recruiting | Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia NCT06534359 | Children's Hospital of Philadelphia | N/A |
| Recruiting | Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms NCT06687603 | Case Comprehensive Cancer Center | N/A |
| Recruiting | Role of Mucosal Impedance Measurement for the Diagnosis of Gastroesophageal Reflux Disease NCT06339801 | Hospital de Clinicas José de San Martín | — |
| Completed | Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry NCT06329583 | Mayo Clinic | N/A |
| Unknown | Mandatory Hiatoplasty in Sleeve Gastrectomy for Gastro-Esophageal Reflux Disease NCT06316167 | Instituto Mexicano del Seguro Social | — |
| Recruiting | A Study of Breath Testing for Small Intestinal Bacterial Overgrowth NCT05976165 | Mayo Clinic | N/A |
| Completed | The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Sympto NCT06075082 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Recruiting | Sleeve-pex: A Randomized Trial to Reduce Reflux After Sleeve Gastrectomy NCT05704348 | Helse Forde | N/A |
| Active Not Recruiting | Biological Sample Repository for Gastrointestinal Disorders NCT05874726 | Pichamol Jirapinyo, MD, MPH | — |
| Not Yet Recruiting | Developing and Testing Mobile Health Question Prompt List in Gastroesophageal Reflux Disease NCT05900687 | Stanford University | N/A |
| Completed | A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma NCT06381583 | City of Hope Medical Center | — |
| Active Not Recruiting | Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD NCT05556824 | Microbiome Health Sciences | Phase 2 |
| Unknown | Anti Reflux Mucosal Ablation Therapy in PPI Dependent GERD NCT05763485 | Technical University of Munich | N/A |
| Completed | Ultrasound Assessment for Comparison of Gastric Residual Volume After Ingestion of Carbohydrate Drink and Wate NCT06941623 | Prince of Songkla University | N/A |
| Unknown | The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy NCT05690022 | Laval University | N/A |
| Unknown | A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux Esophagitis NCT05604261 | Xuanzhu Biopharmaceutical Co., Ltd. | Phase 2 |
| Unknown | Hyaluronic Acid in Patients With Gastroesophageal Reflux Disease NCT05561179 | Instituto Ecuatoriano de Enfermedades Digestivas | N/A |
| Completed | Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy NCT05486169 | University of Warmia and Mazury in Olsztyn | N/A |
| Recruiting | Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants. NCT06031025 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Completed | Manual Therapy and Gastroesophageal Reflux Disease in Patients With Hiatal Hernia NCT05283447 | Escoles Universitaries Gimbernat | N/A |
| Unknown | Gastro-intestinal Physiology After Anti-Reflux Procedures NCT05238636 | St George's, University of London | — |
| Completed | A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Vonoprazan in Adolescents With Sympto NCT05343364 | Phathom Pharmaceuticals, Inc. | Phase 1 |
| Completed | Efficacy and Safety of Thread Embedding Acupuncture in Treating Gastroesophageal Reflux Disease NCT05353933 | University of Medicine and Pharmacy at Ho Chi Minh City | N/A |
| Enrolling By Invitation | Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Diseas NCT04960566 | Northwestern University | N/A |
| Recruiting | Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction NCT05330910 | Sengkang General Hospital | N/A |
| Unknown | Assessment on Effects of Tongjiang Granule in Treating Nonerosive Reflux Disease Overlapping Epigastric Pain S NCT05312463 | Xiyuan Hospital of China Academy of Chinese Medical Sciences | Phase 1 / Phase 2 |
| Unknown | ARMA for Postoperative GERD After Sleeve Gastrectomy NCT05259579 | Chinese University of Hong Kong | N/A |
| Recruiting | High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux NCT05132816 | Prof Urs Zingg | N/A |
| Completed | Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome) NCT04703595 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Unknown | Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux NCT05278689 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Minimally Invasive Evaluation of Dyspepsia by Combined Magnetically Controlled Capsule Endoscopy and Urea Brea NCT04918472 | Chinese University of Hong Kong | N/A |
| Completed | To Investigate the Incidence of Reflux in Patients After Per-oral Endoscopic Myotomy in Achalasia Cardia Patie NCT04951739 | Asian Institute of Gastroenterology, India | — |
| Completed | Usefulness of Wireless pH Monitoring in GERD Diagnosis NCT05452603 | Hospital de Clinicas José de San Martín | — |
| Unknown | Thresholds of Straight Leg Raise Maneuver During High-Resolution-Manometry NCT04813029 | University of Milan | N/A |
| Unknown | Mucosal Impedance Sleeve Gastrectomy NCT04166461 | MetroHealth Medical Center | — |
| Completed | Inclined Positioning and Infant Gastroesophageal Reflux NCT04542239 | Milton S. Hershey Medical Center | — |
| Recruiting | Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction NCT04411823 | Mayo Clinic | N/A |
| Completed | The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole NCT04720781 | Showa Inan General Hospital | N/A |
| Active Not Recruiting | Gracie Diet for Gastroesophageal Reflux Disease NCT04360252 | Johns Hopkins University | N/A |
| Active Not Recruiting | RETHINK REFLUX Registry NCT04253392 | Ethicon Endo-Surgery | — |
| Completed | Tolerability Study of a Novel Microbiome Therapeutic in Subjects With Gastroesophageal Reflux Disease NCT04491734 | ISOThrive Inc. | N/A |
| Unknown | Long Term Incidence and Effect of de Novo GERD After Laparoscopic Sleeve Gastrectomy in Chinese Population NCT04237857 | Chinese University of Hong Kong | — |
| Unknown | Study of Dietary Patterns and Food Diversity in Russian GERD Patients NCT04252144 | Russian Academy of Medical Sciences | N/A |
| Withdrawn | A Study to Reduce the Reflux After a Sleeve Gastrectomy in Obese Patients NCT04287972 | Fabio Garofalo | N/A |
| Completed | Intestinal Adsorbent and Breath Gas Levels NCT04492839 | Dr Anthony Hobson | N/A |
| Enrolling By Invitation | ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia NCT04065516 | Coordinación de Investigación en Salud, Mexico | N/A |
| Withdrawn | Can Individuals Control Pressure in Their Esophagus. NCT03495219 | Mayo Clinic | — |
| Terminated | Antireflux Efficacy of Hiatal Hernia Repairs in Sleeve Gastrectomy Patients NCT04433507 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | N/A |
| Completed | Effect of a Nickel Free Diet and Nickel Sensitization on GERD Patients. NCT03720756 | West Virginia University | N/A |
| Unknown | Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion NCT02087345 | Brain-Gut Research Group | — |
| Completed | Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours NCT03417817 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Completed | Gastroesophageal Reflux Disease Among College Students NCT04034017 | King Khalid University | — |
| Completed | Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease NCT03619811 | University of California, San Diego | N/A |
| Unknown | The Detection of Barrett's Esophagus by Gastrointestinal Endoscopy Prevents Esophageal Carcinoma in Morbid Obe NCT03596411 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort NCT03524781 | University of Southern Denmark | — |
| Completed | Correlations Between Wireless pH Monitoring and Variation in Reflux Symptom Questionnaire, 7 Day Recall NCT03407456 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | Pre and Post-gastrostomy Evaluation of GER in Children Using 24-hour pH Monitoring NCT04454112 | Fatma Demirbaş | N/A |
| Completed | Physiological Predictors of Clinical Outcomes After Anti-reflux Surgery NCT03390634 | Guy's and St Thomas' NHS Foundation Trust | — |
| Unknown | Comparison of Treatment Outcome and Cost-effectiveness for GERD NCT03661151 | Sungsoo Park | — |
| Terminated | Fexofenadine Use in Gastroesophageal Reflux Symptoms NCT03425097 | Stanford University | Phase 2 |
| Unknown | the Related Factors of Bariatric Surgery on Gastroesophageal Reflux Disease NCT03497494 | First Affiliated Hospital of Jinan University | N/A |
| Completed | Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma NCT03015610 | Jason Lang, M.D., M.P.H. | Phase 3 |
| Completed | Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH NCT03735862 | Miromatrix Medical Inc. | — |
| Completed | Methoclopramide for Gastroesophageal Reflux in Premature Infants NCT02907632 | Nathalie Charpak | Phase 4 |
| Terminated | A Trial of Thickened Feeds to Treat Gastroesophageal Reflux in Children Admitted After Choking Spell NCT03130543 | Boston Children's Hospital | N/A |
| Completed | Evaluating the Impact of Automated Evaluation of Gastrointestinal Symptoms (AEGIS) on Clinical Outcomes NCT02530216 | Cedars-Sinai Medical Center | N/A |
| Completed | Study of Gastro-oesophageal Reflux in Patients Having Had Bariatric Surgery NCT03077906 | Pierre Wauthy | — |
| Completed | GER Poses a Potential Risk for Late Complications of BPD NCT03014453 | Shengjing Hospital | — |
| Completed | Prevalence, Predictors and Management of Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy NCT05416645 | Mansoura University | N/A |
| Unknown | Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective A NCT04740437 | University Hospital, Montpellier | — |
| Completed | Pharmacogenetic Testing in Children With Persistent Gastroesophageal Reflux Disease NCT03005080 | Mayo Clinic | — |
| Completed | Mic-Key Versus Mini One Family Preference Comparison NCT03041649 | Children's Mercy Hospital Kansas City | N/A |
| Completed | Influence of Central Obesity on the Esophageal Epithelial Barrier NCT02776982 | Mayo Clinic | N/A |
| Terminated | Determining Risk Factors for Successful PPI Weaning NCT03226054 | Mount Carmel Health System | N/A |
| Completed | Implementation of PPI Medication PGX Testing NCT02794844 | Nemours Children's Clinic | Phase 4 |
| Completed | Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a Hi NCT02743949 | Takeda | Phase 2 |
| Unknown | Effect of Magnesium Alginate on Gastroesophageal Reflux in Infants. NCT02806453 | Policlinico Hospital | Phase 4 |
| Terminated | An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Ref NCT02749071 | EndoStim Inc. | N/A |
| Completed | Patient-Centred Innovations for Persons With Multimorbidity - Quebec NCT02789800 | Université de Sherbrooke | N/A |
| Completed | SWAN: Study on the Tolerance and Efficacy of a New Anti-regurgitation Formula (PC-2016-01) NCT02710955 | United Pharmaceuticals | N/A |
| Terminated | The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Regist NCT02988934 | CDx Diagnostics | — |
| Terminated | Mayo Clinic Foregut Surgery Report Card Questionnaire NCT02708303 | Mayo Clinic | — |
| Completed | 48 Hours Esophagal pH-monitoring With and Without Gaviscon NCT02783378 | Universitair Ziekenhuis Brussel | N/A |
| Completed | Patient-Centred Innovations for Persons With Multimorbidity - Ontario NCT02742597 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Withdrawn | Valvuloplasty as Alternative to Toupet Fundoplication for GERD NCT02625077 | Meander Medical Center | N/A |
| Unknown | MGB/OAGB and LSG Effects on Lower Esophageal Sphincter (LES) Function NCT02987673 | Mario Musella MD | N/A |
| Completed | Effect of Tube Feeding on Gastroesophageal Reflux in Preterm Infants NCT02837627 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Unknown | Gastroesophageal Reflux During LMA in Control Ventilation (LMA, Laryngeal Mask Airway) NCT02441257 | Zhenmeng Wang | N/A |
| Completed | The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Depar NCT02506634 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Terminated | Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection NCT02788591 | LCMC Health | N/A |
| Terminated | Cromolyn Detection of Silent Aspiration NCT01841307 | University of California, San Francisco | Phase 1 |
| Completed | Effects of Diet on Reflux and Dyspepsia NCT02425553 | University of Zurich | — |
| Unknown | Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neopl NCT02464930 | Midwest Biomedical Research Foundation | — |
| Completed | Phenotypic Characterization and Biomarkers Investigation for Eosinophilic Esophagitis in Pediatric Patients NCT03069573 | Federal University of Uberlandia | — |
| Completed | The Gastrointestinal Microbiome of Infants With GERD and PPI Therapy: a Pilot Study NCT02359604 | Medical University of Graz | N/A |
| Withdrawn | Study of the Effects of Pantoprazole on Levels of Prescribed Psychiatric Medications NCT02213887 | University of British Columbia | Phase 4 |
| Completed | Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform NCT02436057 | Cedars-Sinai Medical Center | N/A |
| Completed | Pharmacodynamics and Safety of CDFR0209 NCT02710994 | Ajou University School of Medicine | Phase 1 |
| Completed | Ph2a Study to Evaluate IW-3718 in Patients With Gastroesophageal Reflux Not Completely Responsive to Proton Pu NCT02030925 | Ironwood Pharmaceuticals, Inc. | Phase 2 |
| Unknown | Impact of Swaddle Blanket on Gastroesophageal Reflux NCT02083952 | Valley Health System | N/A |
| Unknown | The Role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis NCT02136394 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Withdrawn | Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD) NCT05695846 | Medical College of Wisconsin | N/A |
| Completed | A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis NCT02755753 | YongChan Lee | Phase 4 |
| Completed | Treatment of IPF With Laparoscopic Anti-Reflux Surgery NCT01982968 | University of California, San Francisco | N/A |
| Unknown | Trial to Assess the Effectiveness of Educational Outreach in Prescription Guidelines NCT01984034 | Universidade Nova de Lisboa | N/A |
| Completed | Lansoprazole in Preterm Infants With Gastroesophageal Reflux (GER) NCT01946971 | Seoul National University Hospital | Phase 1 / Phase 2 |
| Completed | Study on the Tolerance and Efficacy of a New Anti Regurgitation Formula NCT02425423 | United Pharmaceuticals | Phase 3 |
| Completed | Effects of Non-Nutritive Sucking on Gastroesophageal Reflux and Related Apneas in Symptomatic Preterm Infants NCT02023216 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Prevalence and Predictors of Proton Pump Inhibitor Partial Response in Gastroesophageal Reflux Disease in Syst NCT03561233 | Khon Kaen University | Phase 1 |
| Recruiting | Compassionate Use of Domperidone for Refractory Gastroparesis NCT04699591 | Jose Cocjin | N/A |
| Unknown | Prospective, Comparative, Randomized, Controlled Trial on the Efficacy of the Treatment of Gastroesophageal Re NCT01858584 | Federico II University | N/A |
| Completed | A Study of Local Effect and Safety of a Single PPC-5650 Dose on Reflux Pain During Pain Stimulation in the Eso NCT01818570 | Asbjørn Mohr Drewes | Phase 1 |
| Unknown | Study of Erythromycin in GER-Associated Apnea of the Newborn NCT01825473 | University of Virginia | N/A |
| Completed | Effects of Serotonin Agonist Buspirone on Multimodal Esophageal Stimulation in Healthy Volunteers NCT04352686 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | BRAVO Study for Functional Dyspepsia NCT01349413 | Chinese University of Hong Kong | Phase 4 |
| Completed | Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers NCT04355455 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | Phase III Study Comparing Zegerid® With Losec® for the Relief of Heartburn Associated With Gastroesophageal Re NCT01493089 | Norgine | Phase 3 |
| Recruiting | External UES Band (Shaker Pressure Band) and GERD NCT05697393 | Medical College of Wisconsin | N/A |
| Completed | Comparative Anti-Reflux Procedures in Neurologically Impaired Children NCT01307982 | University of Utah | N/A |
| Unknown | Barrett's Esophagus Patient Registry NCT01776346 | Massachusetts General Hospital | — |
| Completed | A Study of Disposable Transnasal Esophagoscope NCT01360515 | Yonsei University | — |
| Withdrawn | Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability NCT01028183 | Duke University | — |
| Completed | Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subject NCT01136317 | Nantes University Hospital | Phase 2 |
| Completed | Non-interventional Study to Evaluate the Change in Symptoms Scores and Treatment Response After 4 Weeks of Pro NCT01103804 | AstraZeneca | — |
| Completed | Study to Evaluate the Pharmacokinetics and Safety of Dexlansoprazole in Pediatric Subjects With Symptomatic Ga NCT01045096 | Takeda | Phase 1 |
| Completed | Esophageal Atresia: Metaplasia, Barrett NCT02495051 | University Hospital, Lille | — |
| Completed | Observational Study of Anti-Reflux Surgery NCT01624506 | Torax Medical Incorporated | — |
| Completed | Active Control, Double-blind, Double-dummy, Parallel-group, Randomized Study to Assess the Effect of VECAM 40/ NCT01059383 | Vecta Ltd. | Phase 2 |
| Completed | MSG and Gastrointestinal Motility NCT01009658 | Gunma University | N/A |
| Completed | Safety and Efficacy of Rabeprazole in Infants With Gastroesophageal Erosive Reflux Disease (GERD) NCT00992589 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Terminated | Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus NCT01129778 | Stanford University | N/A |
| Completed | Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin NCT01053286 | University of California, Davis | — |
| Completed | A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in New Born Infants With Gastroesophageal NCT00855361 | Janssen Research & Development, LLC | Phase 1 |
| Completed | Laparoscopic Sleeve Gastrectomy and Gastroesophageal Acid Reflux NCT02012894 | University of Turin, Italy | — |
| Completed | Intravenous (IV) Pantoprazole for Gastroesophageal Reflux Disease (GERD) in Neonates and Infants NCT00744419 | University of Louisville | Phase 1 |
| Completed | Pharmacokinetic and Safety of Dexlansoprazole in Adolescents With Gastroesophageal Reflux Disease NCT00847210 | Takeda | Phase 1 |
| Completed | MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use NCT01050465 | University of Missouri-Columbia | N/A |
| Completed | Efficacy of Dexlansoprazole MR on Heartburn Control in Participants Previously Receiving Twice Daily Proton Pu NCT00847808 | Takeda | Phase 3 |
| Completed | Esophageal Bolus Transit in Newborns With Gastroesophageal Reflux Disease NCT02167984 | University of Turin, Italy | — |
| Terminated | Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD NCT00624546 | University of Rochester | — |
| Completed | ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD) NCT00810485 | Addex Pharma S.A. | Phase 2 |
| Completed | Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH NCT00818870 | Vecta Ltd. | Phase 1 |
| Completed | ADX10059 as a Monotherapy in Patients With Gastroesophageal Reflux (GERD) NCT00820079 | Addex Pharma S.A. | Phase 2 |
| Completed | LINX Reflux Management System Clinical Study Protocol NCT00776997 | Torax Medical Incorporated | N/A |
| Completed | A Pharmacokinetic and Relative Bioavailability Study With Rabeprazole Sodium in Healthy Adult Volunteers NCT01101646 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 1 |
| Completed | An Assessment of pH Testing Methods NCT01364610 | University of Calgary | N/A |
| Completed | Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in So NCT01018160 | Janssen Korea, Ltd., Korea | — |
| Completed | Prevalence of Gastroesophageal Reflux During Childhood and Teenage Years in France NCT00681837 | AstraZeneca | — |
| Completed | Does Cholecystectomy Increase the Esophageal Alkaline Reflux? Evaluation by Impedance-pH Technique NCT01047085 | Istanbul University | N/A |
| Completed | A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn NCT00627016 | Takeda | Phase 3 |
| Completed | Pepsin As A Biomarker For Aspiration NCT00865995 | Medical College of Wisconsin | — |
| Completed | An Efficacy and Safety Study of XP19986 in Subjects With Symptomatic GERD NCT00557401 | XenoPort, Inc. | Phase 2 |
| Completed | Coordination Versus Pressure in Oesophageal Peristalsis NCT00482885 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | Study of Changes in Reflux Symptoms and Reflux Finding Score According to Rabeprazole Treatment Period NCT00614536 | Janssen Korea, Ltd., Korea | — |
| Terminated | COPD Patients Diagnosed With GERD,COPD Exacerbations After Treatment With High Dose PPI NCT00523367 | University of Florida | N/A |
| Completed | GI Reflux in Lung Transplant and Its Relationship to Chronic Rejection NCT00455078 | University of Chicago | — |
| Recruiting | Barrett's Esophagus Related Neoplasia (BERN) Project NCT00590239 | Midwest Biomedical Research Foundation | — |
| Terminated | Omeprazole and Reflux Disease - Improvement of Clinical Outcome by Genotype-adjusted Dosing NCT00537732 | Matthias Schwab | Phase 4 |
| Terminated | Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppress NCT00444236 | University of Utah | Phase 1 |
| Terminated | Domperidone for Gastroparesis in Solid Organ Transplantation NCT00552422 | David J. Lederer, M.D. | N/A |
| Completed | Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treat NCT00444145 | Vanderbilt University Medical Center | Phase 4 |
| Terminated | Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux NCT00451841 | University of Massachusetts, Worcester | — |
| Completed | Study Evaluating Pantoprazole in Adolescents With GERD NCT00367614 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Non-erosive Reflux or Gastroesop NCT00326027 | Nycomed | Phase 3 |
| Completed | Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux NCT00373997 | Vanderbilt University | Phase 4 |
| Completed | Study Evaluating the Efficacy and Safety of Pantoprazole in Infants With Symptomatic Gastroesophageal Reflux D NCT00365300 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers NCT00284908 | STEBA France | Phase 1 |
| Terminated | Elucidation of Acid-Induced Pulmonary Inflammation NCT00361972 | University of Utah | Phase 2 / Phase 3 |
| Withdrawn | Tongue Exercises and Reflux Therapy for Upper Airway Resistance Syndrome NCT00364481 | West Side ENT | Phase 1 |
| Withdrawn | Proton Pump Inhibitor Therapy for Mild to Moderate Obstructive Sleep Apnea NCT00211614 | MetroHealth Medical Center | N/A |
| Completed | Study Evaluating Pantoprazole in Neonates and Preterm Infants With GERD NCT00362609 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Study Evaluating Pantoprazole in Children With Gastroesophageal Reflux Disease (GERD) NCT00300755 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux NCT02618044 | University of Turin, Italy | — |
| Unknown | Serial Exhaled Breath pH Monitoring NCT00330603 | University of Virginia | — |
| Completed | The Influence of Hypnotic Medications on Sleep Arousal and Its Effect on Gastroesophageal Reflux NCT00462137 | Thomas Jefferson University | — |
| Completed | Open Label Safety Study of Enteric-Coated Spheroid Suspension in Infants Aged Less Than 12 Months With Presume NCT00868296 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Withdrawn | Longitudinal Study of Children With a Chronic Cough and the Impact of Gastroesophageal Reflux NCT00771706 | Massachusetts Eye and Ear Infirmary | Phase 3 |
| Completed | Esomeprazole and Gastric Emptying of Beer NCT00472550 | Heidelberg University | Phase 4 |
| Completed | Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children NCT00382850 | Johns Hopkins University | N/A |
| Completed | Determination of the Minimal Clinically Important Difference After Treatment With Pantoprazole in Patients Wit NCT00246909 | Takeda | Phase 4 |
| Completed | Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD NCT00259012 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Novel Imaging Techniques in Barrett's Esophagus NCT00576498 | Midwest Biomedical Research Foundation | N/A |
| Completed | Examine National Characteristics & Outcome Measures of GERD Patients Using the PPI Acid Suppression Symptom (P NCT00392002 | AstraZeneca | Phase 4 |
| Completed | Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease NCT00215787 | Head and Neck Surgery Associates | N/A |
| Completed | German PMS Trial (AWB) to Evaluate Therapy in Reflux Disease and NSAR-Symptoms NCT00567021 | AstraZeneca | — |
| Completed | Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants. NCT00226044 | Rijnstate Hospital | Phase 3 |
| Completed | Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease NCT01167543 | University of California, San Francisco | — |
| Completed | Famotidine in Subjects With Non-erosive Gastroesophageal Reflux Disease NCT00141960 | Astellas Pharma Inc | Phase 2 / Phase 3 |
| Completed | Validation of RDQ Questionnaire NCT00291746 | AstraZeneca | Phase 4 |
| Completed | Study Evaluating Pantoprazole in Children With GERD NCT00141817 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patient NCT00261339 | Takeda | Phase 4 |
| Completed | Importance of Non-Acid Reflux in Asthma in Children NCT00200980 | Nemours Children's Clinic | — |
| Completed | Improvement in Bronchial Asthma in Patients With Extraesophageal Reflux After Acid Suppression NCT00234117 | Ponce Gastroenterology Research | N/A |
| Completed | Study Comparing a Pantoprazole Formulation to the Currently Marketed Tablet for GERD and Erosive Esophagitis NCT00195208 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Evaluation of Gastroesophageal Reflux in Patients on Continuous Positive Airway Pressure Ventilation for Obstr NCT00194376 | University of Pennsylvania | N/A |
| Completed | Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Re NCT00163306 | Takeda | Phase 3 |
| Completed | HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease NCT00243724 | AstraZeneca | Phase 3 |
| Completed | Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine - NCT00229424 | Taiho Pharmaceutical Co., Ltd. | Phase 3 |
| Completed | Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy NCT00170001 | Mayo Clinic | N/A |
| Completed | Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treat NCT00517114 | Hospital Authority, Hong Kong | N/A |
| Completed | Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age NCT01048840 | Massachusetts General Hospital | — |
| Completed | Natural History of Gastroesophageal Reflux (GER) in Children and Adolescents NCT00181805 | Massachusetts General Hospital | — |
| Completed | Open Label Study Evaluating Different Dosing Regimens of Rabeprazole in Gastro-esophageal Reflux Disease (GERD NCT00553449 | Janssen-Ortho Inc., Canada | Phase 3 |
| Completed | ASTERIX: Low Dose ASA and Nexium NCT00251966 | AstraZeneca | Phase 3 |
| Completed | Chest Pain Pilot Study NCT00251901 | AstraZeneca | Phase 3 |
| Completed | Medical Treatment for Gastroesophageal Reflux Disease (GERD) in Preterm Infants NCT00131248 | The University of Texas Health Science Center, Houston | Phase 3 |
| Terminated | Quantifying Effects of Treatment of Pediatric Dysphonia NCT00237679 | University of Wisconsin, Madison | N/A |
| Completed | Endoscopic Implantation of Enteryx for the Treatment of GERD NCT00346905 | Beth Israel Deaconess Medical Center | N/A |
| Terminated | A Study of Cisapride in Patients With Symptomatic Gastro-Oesophageal Reflux Disease NCT01281553 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 4 |
| Completed | Treatment Of Gastroesophageal Reflux Disease By Endoscopic Fundoplication, A Placebo-Controlled Study NCT00235677 | UMC Utrecht | Phase 3 |
| Completed | A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD) NCT00216489 | Janssen Cilag Pharmaceutica S.A.C.I., Greece | Phase 4 |
| Terminated | Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ? NCT01551134 | Oslo University Hospital | N/A |
| Unknown | The Use of Proton Pump Inhibitor for the Treatment of Non-erosive Gastro-oesophageal Reflux Disease in Chinese NCT00516971 | Hospital Authority, Hong Kong | N/A |
| Terminated | Demographics and Findings of Upper Endoscopy Patients NCT00576992 | Midwest Biomedical Research Foundation | — |
| Completed | Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures NCT01260935 | Swedish Medical Center | N/A |
| Completed | On Demand Treatment of Reflux Disease NCT00184522 | Norwegian University of Science and Technology | Phase 4 |
| Completed | Safety and Efficacy of Lansoprazole in Patients With Reflux Disease NCT01135368 | Takeda | Phase 4 |
| Active Not Recruiting | Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus NCT00431756 | Johns Hopkins University | — |
| Completed | Esomeprazole (NEXIUM) vs. Surgery NCT00251927 | AstraZeneca | Phase 3 |
| Completed | A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosiv NCT00236392 | Janssen Pharmaceutica N.V., Belgium | Phase 3 |
| Completed | Open, Randomised, Multi-center Study of on Demand Versus Continuous Esomeprazole Treatment in Patient With GER NCT02670642 | AstraZeneca | Phase 3 |
| Completed | Laparoscopic Nissen Versus Anterior Partial Fundoplication NCT01669330 | Region Skane | N/A |
| Completed | A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD NCT00182260 | McMaster University | N/A |
| Completed | Laparoscopic Nissen Fundoplication Comparing Division Versus Non-Division of Short Gastric Vessels NCT00852098 | Federal University of São Paulo | N/A |
| Terminated | Influence of Hygiene-dietetic Habits and Treatment Adherence on the Effectiveness of the Gastroesophageal Refl NCT00511966 | Janssen-Cilag, S.A. | — |
| Unknown | Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Aci NCT00231881 | Nantes University Hospital | — |
| Terminated | Safety of Rabeprazole in Patients Under Multiple Treatments NCT00511745 | Janssen-Cilag, S.A. | — |
| Completed | Medical and Surgical Treatment of Esophageal Reflux NCT00061724 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |
| Withdrawn | Randomized Trial for Pharmacogenomics-based Proton Pump Inhibitor Therapy in Children NCT00299845 | Osaka University | Phase 4 |
| Completed | A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroes NCT00237367 | PriCara, Unit of Ortho-McNeil, Inc. | Phase 4 |
| No Longer Available | Domperidone Expanded Access Protocol for Patients With Gastrointestinal Disorders NCT02567175 | Prasanna K Kapavarapu | — |