NCT01009658

MSG and Gastrointestinal Motility

Effect of Monosodium Glutamate on Upper Gastrointestinal Tract Motility

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Gunma University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).

Detailed description

Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption. . To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.

Conditions

• Gastroesophageal Reflux

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Monosodium glutamate	Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.
DIETARY_SUPPLEMENT	Sodium chloride	Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.

Timeline

• Start date: 2009-12-01
• Primary completion: 2015-03-01
• First posted: 2009-11-09
• Last updated: 2015-03-26

Locations

1 site across 1 country: Japan