| Not Yet Recruiting | The Importance of Anesthesia Method in Fragile Patients NCT07191769 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | — |
| Not Yet Recruiting | Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults NCT07182292 | Fundacion Miguel Servet | N/A |
| Recruiting | Patient's Database: Prepare for Your Surgery Program NCT06857981 | Pontificia Universidad Catolica de Chile | — |
| Recruiting | The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging NCT06208527 | Haukeland University Hospital | Phase 2 |
| Not Yet Recruiting | Effectiveness of a Socio-Community Health Intervention on Pre-Frailty in Older Adults NCT06663150 | Keralty SAS. Colombia | N/A |
| Recruiting | The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM NCT06469437 | Hospital de Clinicas de Porto Alegre | N/A |
| Recruiting | INTEgRated Health CARE for Patients With Frailty and Heart Failure NCT06444321 | Vestre Viken Hospital Trust | N/A |
| Recruiting | Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams NCT05993754 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Fra NCT06438718 | Instituto de Investigación Sanitaria Aragón | — |
| Active Not Recruiting | Comparative Analysis of Risk Factors and Prediction of Frailty Syndrome NCT06496022 | Asfendiyarov Kazakh National Medical University | — |
| Unknown | Medical Monitoring of Older Adults Patients After Discharged From Heart Failure Hospitalization NCT06018532 | Presage | N/A |
| Completed | AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program NCT06079762 | Brigham and Women's Hospital | N/A |
| Unknown | eHealth for Screening Health Risks in Home-Based Older Adults: A Prospective Study NCT06019390 | Presage | N/A |
| Completed | Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults NCT05961319 | University of Alberta | — |
| Completed | The Effect of Health Promotion Comprehensive Education Intervention on the Frailty Levels of Elderly Family Ca NCT06064227 | Fatma Banu Demirdas | N/A |
| Unknown | Comparison of Kinesiophobia, Balance, Falling and Walking Speeds of Elderly's With Physical Frailty With Alzhe NCT05761665 | Kırıkkale University | — |
| Completed | Protocols and Guidelines for the Use of Digital Twins in Frail Older People NCT05854316 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | Frailty Assessment in Vascular Hot Clinic Setting - Feasibility and Prognostic Value NCT06040658 | University of Glasgow | — |
| Completed | Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure. NCT05393362 | University of Malaga | N/A |
| Unknown | ICT-supported Multidimensional Approach for Frailty Screening in Community-dwelling Individuals Aged ≥ 65 Year NCT05646472 | Federico II University | — |
| Completed | A Health Promotion Program to Prevent Frailty and Improve Frailty Status Among Pre-frail Elderly: Frailty Inte NCT04327544 | Universiti Putra Malaysia | N/A |
| Enrolling By Invitation | Assessing a New Tool to Assess Frailty in Frail Hospitalized Elderly NCT04366388 | University of British Columbia | — |
| Active Not Recruiting | Implementing, Evaluating, and Scaling Up of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC NCT03935997 | McMaster University | N/A |
| Unknown | PeRsonalizing the Approach to the Oncologic Frail Individual Through Tailored Assessment and Intervention (PRO NCT05319145 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Completed | Education for Prevention and Treatment of Frailty NCT05610605 | University of Cadiz | N/A |
| Completed | A Digital Home-Based Physiotherapy Program for Active Aging NCT06381336 | Trak Health Solutions S.L. | N/A |
| Unknown | Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican NCT04504968 | Consorcio Centro de Investigación Biomédica en Red (CIBER) | N/A |
| Recruiting | Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplina NCT04461301 | Insel Gruppe AG, University Hospital Bern | N/A |
| Unknown | Influence of Preoperative Nutritional Status on Perioperative Period in Cardiac Surgery in Patients With Frail NCT05118165 | Lithuanian University of Health Sciences | N/A |
| Completed | Frailty Prevention in Elders From Reunion Island NCT05090241 | Universite de La Reunion | — |
| Unknown | Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Con NCT05940779 | University of Valencia | N/A |
| Completed | Protocol of Geriatric Rehabilitation in Patients of 60 and Older Who Live in Moscow Boarding Houses or Nursing NCT05740436 | Pirogov Russian National Research Medical University | — |
| Unknown | Investigation of Relation With Preoperative Fragility and ASA Score in Elderly Patients NCT05078983 | Gulhane Training and Research Hospital | — |
| Unknown | Characterising Frailty Using Magnetic Resonance Imaging NCT04612686 | University of Nottingham | — |
| Completed | Pre-surgical Protocol for Frail Elderly People in Order to Reduce Hospitalization Days (APOPM). NCT04770259 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Effect of Baduanjin on Functional Performance in Pre-Frail/Frail Older Adults NCT04549103 | Geriatric Education and Research Institute | N/A |
| Completed | Immediate Dental Prosthesis Functionalization Protocol in People Over 70 Years of Age NCT05818436 | University of Chile | N/A |
| Unknown | Efficacy of Preoperative Prehabilitation With a Home-based Supervised Exercise Program Against an Unsupervised NCT04892368 | Singapore General Hospital | N/A |
| Active Not Recruiting | Multifactorial Fall Prevention Program NCT05682872 | Castilla-La Mancha Health Service | N/A |
| Unknown | Screening of the Frailty Degree in the Emergency Department Short Stay Unit NCT04812834 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Unknown | Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs NCT04592146 | Hospital Universitario Getafe | N/A |
| Completed | Validity Reliability of FrailBESTest in Older Adults NCT04615533 | Kırıkkale University | — |
| Unknown | The Dynamics of Frailty in Older People NCT04139278 | University of Southampton | — |
| Withdrawn | Effect of an Intervention on Health in Older Care Home Residents NCT04659694 | Bournemouth University | N/A |
| Completed | TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults NCT04893746 | National Taiwan Sport University | N/A |
| Completed | Frailty and Surgery NCT05594277 | Università degli Studi del Piemonte Orientale Amedeo Avogadro | — |
| Unknown | The Prediction Model of Elderly Patients in Taiwan Triage and Acuity Scale NCT04862936 | Chang Gung Memorial Hospital | — |
| Completed | Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy NCT04293653 | Haukeland University Hospital | N/A |
| Unknown | The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary S NCT04580706 | Beijing Friendship Hospital | — |
| Unknown | Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical S NCT04238494 | University Hospital, Bordeaux | N/A |
| Unknown | Cognition and the Immunology of Postoperative Outcomes NCT04792983 | Brigham and Women's Hospital | — |
| Completed | Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction NCT04056871 | University of Malaya | — |
| Completed | Multidimensional Intervention in Pre-frail Patients Older Than 70 Years NCT04574271 | Endocrinology and Clinical Nutrition Research Center, Spain | N/A |
| Completed | Nutritional Status and Its Modifications After Hip Replacement NCT03981354 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | Home-based Prehabilitation for Elderly Patients NCT03964363 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Unknown | Discharge Planning in Emergency Department for Frail Older With AHF NCT03696875 | F. Javier Martin Sanchez | N/A |
| Unknown | Immunophenotype of Risk in Older Patients Admitted for Pneumonia NCT04062799 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Active Not Recruiting | Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery NCT03913299 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Unknown | Effects of a Multicomponent Exercise and Supplementation of BCAA´s in Immunity System Dwelling Elderly NCT04376463 | University of Coimbra | N/A |
| Completed | Protocol for Multi-site Evaluation of New Community-based Frailty Programme NCT04866316 | Geriatric Education and Research Institute | — |
| Unknown | Frailty Heart Failure Study NCT03887351 | Jewish General Hospital | — |
| Unknown | Keeping Active in Residential Elderly NCT03141879 | University of Birmingham | N/A |
| Completed | HMB Supplementation in Addition to Multicomponent Exercise in Old Adults NCT03827499 | Universidad de Murcia | N/A |
| Completed | Frailty and Postoperative Outcomes After Gastric Cancer Surgery NCT03568110 | Parc de Salut Mar | — |
| Completed | Older Adult Safety in Surgery IV (OASIS) NCT03892187 | University of Massachusetts, Worcester | N/A |
| Unknown | Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks NCT03577002 | Oregon Health and Science University | N/A |
| Completed | The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis NCT03944824 | Satellite Healthcare | N/A |
| Completed | Geriatric Assessment and Intervention in Older Patients Undergoing Surgery for Colorectal Cancer NCT03719573 | Herlev and Gentofte Hospital | N/A |
| Completed | The Effects of the Oral Nutritional Supplement With β-hydroxy-β-methylbutyrate in Lean Body Mass Among Taiwan NCT03792711 | National Yang Ming Chiao Tung University | N/A |
| Completed | Leucine Supplementation in Sarcopenic Older Individuals NCT03831399 | University of Valencia | Phase 1 |
| Unknown | Frailty Assessment of Patients With Gastrointestinal Surgery NCT03930082 | Ziqiang Wang,MD | — |
| Unknown | HOPE (Healthy Older People Everyday) To Age in Place NCT03797352 | National University Hospital, Singapore | N/A |
| Completed | Geriatric Assessment and Intervention for Older Patients With Frailty in the Emergency Department NCT03751319 | Helsinki University Central Hospital | N/A |
| Completed | Validation of a Record-based Frailty Assessment According to the Multidimensional Prognostic Index NCT03794674 | University of Aarhus | — |
| Enrolling By Invitation | Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults NCT03675724 | Mayo Clinic | Phase 2 |
| Completed | Physical Fitness, Body Composition and Frailty in Elderly People.Exercise Program Effecsts. EXERNET Elder 3.0 NCT03831841 | Universidad de Zaragoza | N/A |
| Completed | Outcome of Very Old Patients Admitted for Elective Major Surgery, the Effect of Frailty NCT03721471 | Haukeland University Hospital | — |
| Completed | Effects of WBV Associated With IMT on Functionality NCT03688932 | Universidade Federal de Pernambuco | N/A |
| Completed | Effects of WBV Associated With IMT on Inflammatory Markers, Body Composition, Muscle Strength and Thickness NCT03689322 | Universidade Federal de Pernambuco | N/A |
| Unknown | Frailty and Sarcopenia Outcomes in Emergency General Surgery NCT03534765 | Yeovil District Hospital NHS Foundation Trust | — |
| Unknown | Seated Physical Activity in Ageing NCT03141866 | University of Birmingham | N/A |
| Completed | Frailty and Complexity Among Home Service Recipients NCT03883425 | School of Health Sciences Geneva | — |
| Completed | BABEL Advance Care Planning in Long-term Care NCT03649191 | University of Manitoba | N/A |
| Unknown | Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study NCT03627793 | University of Glasgow | N/A |
| Completed | Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients NCT03636412 | The Cleveland Clinic | N/A |
| Completed | Frailty Assessment and Treatment Strategies in the Elderly at Risk of Functional Decline in the Community NCT03591055 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Unknown | Management of Frailty in Older Adults With Turmeric and Tulsi Supplements NCT03365310 | Composite Interceptive Med Science | N/A |
| Completed | Implementing Advance Care Planning Conversation Tools in Family Practice NCT03508557 | McMaster University | N/A |
| Completed | A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly NCT05832853 | Guang Yang, Prof. Dr. | N/A |
| Completed | Frailty Prevention Program to Prevent Frailty Among Older African Americans NCT03585972 | Wayne State University | N/A |
| Completed | Investigating My Active and Healthy Aging NCT03342976 | University of Turin, Italy | N/A |
| Completed | Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness NCT04651894 | Central Hospital, Nancy, France | — |
| Unknown | Evaluation of Community-based Care for the Frail Elderly NCT03768050 | Hospital Clinic of Barcelona | N/A |
| Unknown | Discontinuation of Long-term Medications in Older People Entering Nursing Home Care NCT03501108 | University College Cork | N/A |
| Suspended | Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Frailty-Aging Processes NCT03514537 | Healeon Medical Inc | N/A |
| Withdrawn | Telerehabilitation in Geriatric Patients at Aarhus University Hospital, Denmark NCT03952858 | University of Aarhus | N/A |
| Enrolling By Invitation | Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women NCT03430037 | Mayo Clinic | Phase 2 |
| Completed | Low Intensity Training Combined With KAATSU on Muscle Vasodilatation and Arterial Stiffness in the Elderly Pop NCT03272737 | Hospital Israelita Albert Einstein | N/A |
| Completed | The Relationship Between Atrial Fibrillation and Frailty in Community-Dwelling Elderly NCT03420326 | National Taiwan University Hospital | — |
| Completed | A Prospective Study Frailty for Esophagectomy and Lung Resection in Thoracic Surgery NCT03413449 | The Cleveland Clinic | — |
| Completed | Exercise Mediation on Hormonal, Immune and Psychological Well-being in Institutionalized Frail Older Women. NCT04435899 | University of Coimbra | N/A |
| Recruiting | Antibiotic Dosing in Geriatric Patients At the Emergency Department NCT04436991 | University Hospital, Ghent | — |
| Completed | Models of Care in the Transition From the Secondary to the Primary Sector Among the Frailest Elderly NCT03796923 | University of Aarhus | N/A |
| Unknown | Frailty Assessment in Elderly Patients With Acute Coronary Syndrome NCT03365505 | Meir Medical Center | — |
| Completed | Transforming Primary Care for Older Canadians Living With Frailty NCT03442426 | University of Waterloo | N/A |
| Completed | Coach2Move: Sustainable in Daily Practice NCT03212859 | Radboud University Medical Center | N/A |
| Terminated | Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation NCT03308435 | Medical University of Graz | — |
| Unknown | Effects of Music and Dance on Cognition, Frailty, and Burden in Elderly Caregivers Living in Rural Communities NCT03068299 | Universidade Federal de Sao Carlos | N/A |
| Completed | Enhanced Primary Care for Elderly NCT03180606 | Region Östergötland | — |
| Completed | Frailty Prevention in Elders From Reunion Island NCT03271112 | Centre Hospitalier Universitaire de la Réunion | N/A |
| Recruiting | Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People NCT04518423 | The Opole University of Technology | — |
| Withdrawn | Fortified Foods in Older Inpatients NCT03176030 | University Hospital Southampton NHS Foundation Trust | — |
| Unknown | Impact of a Multicomponent Exercise Program on Functional Capacity in Frail Aged Participants With Cognitive D NCT03657940 | Fundacion Miguel Servet | N/A |
| Completed | Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly NCT03724461 | University of Castilla-La Mancha | N/A |
| Completed | Integrated Care for Frail Older People NCT03260933 | King's College London | — |
| Completed | No Association Between Vitamin C and E Supplementation, Frailty, and Grip Strength Over Five Years: The CoLaus NCT03258970 | Centre Hospitalier Universitaire Vaudois | — |
| Completed | the Invasive and Conservative Strategies in Elderly Frail Patients With Non-STEMI NCT03208153 | University of Valencia | N/A |
| Withdrawn | Biodex Sit2Stand for Individuals With Cardiac Disease NCT03170011 | St. Ambrose University | N/A |
| Recruiting | Frailty Syndrome in Daily Practice of Interventional Cardiology Ward NCT03209414 | Medical University of Silesia | — |
| Completed | Preoperative Cognitive Screening in Older Spinal Surgical Patients NCT02922634 | Brigham and Women's Hospital | — |
| Terminated | Perioperative Multimodal Care for Cystectomy Frail Patient NCT03065348 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | FOCUS Guidelines and Adherence to Physical Activity in Ageing Women. NCT03981965 | University of Valencia | N/A |
| Unknown | Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly NCT03292744 | Indonesia University | Phase 4 |
| Completed | Frailty, Anesthesia and Complications. NCT04264351 | Fundacio Puigvert | — |
| Completed | Effects of COcoa Supplement in FRail Elderly Subjects (COFRE) NCT03585868 | National Polytechnic Institute, Mexico | N/A |
| Unknown | Subjective Factors of Polymedication in the Elderly: a Qualitative Study of the Perceptions of Patients, Relat NCT03309228 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | A Machine Learning Algorithm to Predict Health Clinical Situations in Primary Healthcare for Frail Older Adult NCT06013709 | Presage | — |
| Completed | Protein Intake and Resistance Training in Aging NCT01890382 | University of Sao Paulo | N/A |
| Completed | GrandMove Project to Promote Elders' Robustness Against Frailty NCT05397288 | The University of Hong Kong | N/A |
| Completed | Mobile Geriatric Teams: Patient Safety and Healthcare Utilization NCT03662945 | Jonkoping University | N/A |
| Unknown | Multi-level Integration for Patients With Complex Needs Facilitated by ICTs. A Shared Approach, Mutual Learnin NCT03042039 | Him SA | — |
| Completed | Development of Clinical Indicators From the Swiss RAI-HC NCT03139162 | School of Health Sciences Geneva | — |
| Completed | Taiwan Health Promotion Intervention Study for Elders NCT03056768 | Taipei Veterans General Hospital, Taiwan | N/A |
| Completed | SMARTCARE Project: Deploying Integrated Health & Social Services for Independent Living by Older People NCT03112109 | Him SA | — |
| Completed | 12-week Pilates Program on Community-dwelling Middle-aged Women NCT05333484 | National Taipei University of Nursing and Health Sciences | N/A |
| Completed | Atrial Fibrillation: Risk and Benefits of Anti-coagulation in the Elderly NCT03828162 | Karolinska Institutet | — |
| Completed | Development and Validation of a Preoperative Frailty Index Using Health Administrative Data NCT03354546 | Ottawa Hospital Research Institute | — |