NCT01890382

Protein Intake and Resistance Training in Aging

Different Protein and Derivatives Supplementation Strategies Combined With Resistance Training in Pre-frail and Frail Elderly

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Resistance training combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related disabilities and comorbidities. Randomized controlled trials supporting this possibility are still scarce. These series of clinical trials aim to investigate the chronic effects of different strategies of protein and derivatives supplementation in association with resistance training on selected health-related parameters in pre-frail and frail elderly.This is a 16-month, double-blind, randomized, placebo-controlled, parallel-group clinical trial involving a series of investigations. Participants will be divided into nine groups, allowing the assessement of the effects of (1) isolated leucine supplementation; (2) protein source (whey vs. soy); (3) combination of whey protein and creatine; and (4) sexual dimorphism to the response of protein intake plus resistance training (men vs. women). All participants will undergo a supervised, resistance training program.

Conditions

• Frail Elderly Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey protein	30 g in total; twice a day (morning and evening)
DIETARY_SUPPLEMENT	whey plus creatine	whey protein combined with creatine (30 g and 6.0 g in total; twice a day, respectively)
DIETARY_SUPPLEMENT	leucine supplementation	7.5 g/d in total; three times per day
DIETARY_SUPPLEMENT	soy protein	30 g in total; twice a day
DIETARY_SUPPLEMENT	creatine	6.0 g in total; twice a day
DIETARY_SUPPLEMENT	placebo

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-08-30
• Completion: 2017-08-30
• First posted: 2013-07-01
• Last updated: 2019-02-15

Locations

1 site across 1 country: Brazil