Trials / Unknown
UnknownNCT04062799
Immunophenotype of Risk in Older Patients Admitted for Pneumonia
Identification of an Immunophenotype of Risk of Poor Prognosis in Elderly Patients Who Have Been Admitted for Pneumonia
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 174 (estimated)
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
The objective is to evaluate if the immune risk phenotype (IRP) in patients who have been admitted for pneumonia predisposes to worse long-term outcomes. In addition, the association between the detected immunological alterations and clinical, functional, nutritional or comorbidity risk factors will be evaluated. If the hypothesis is confirmed, helpful immunological markers will be identified. This will be useful in clinical practice to identify patients who can benefit from an intervention and / or to identify the best time for vaccination. Otherwise, valuable information will be obtained on the interrelation between immunological, clinical, functional and nutritional aspects.
Detailed description
The objective is to evaluate if the immune risk phenotype (IRP) in patients who have been admitted for pneumonia predisposes to worse long-term outcomes. In addition, the association between the detected immunological alterations and clinical, functional, nutritional or comorbidity risk factors will be evaluated. Methodology: Prospective observational study. It will include 149 patients ≥ 65 years admitted for pneumonia. After 30-45 days of pneumonia diagnosis, a complete clinical, functional, nutritional and immunological assessment will be carried out. FRI will be defined as a positive cytomegalovirus serology together with at least one of the following: CD4 / CD8 \<1, CD8 T cells\> 600 / μl or negative CD28 T cells\> 300 / μl15. Mortality and re-admissions at 12 and 18 months will be evaluated. If the hypothesis is confirmed, helpful immunological markers will be identified. This will be useful in clinical practice to identify patients who can benefit from an intervention and / or to identify the best time for vaccination. Otherwise, valuable information will be obtained on the interrelation between immunological, clinical, functional and nutritional aspects.
Conditions
- Age Associated Immune Deficiency
- Elderly Infection
- Pneumonia
- Nutrition Disorders in Old Age
- Frail Elderly Syndrome
- Sarcopenia
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | no intervention | It is an observationa study. There is no intervention. |
Timeline
- Start date
- 2019-05-09
- Primary completion
- 2023-07-01
- Completion
- 2024-01-01
- First posted
- 2019-08-20
- Last updated
- 2021-11-23
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT04062799. Inclusion in this directory is not an endorsement.