| Not Yet Recruiting | Raising Awareness of Colorectal Screening in American Indian Communities NCT07515729 | University of Oklahoma | — |
| Not Yet Recruiting | Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases NCT07321847 | Immunophotonics, Inc. | Phase 2 / Phase 3 |
| Recruiting | Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer NCT07448142 | Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | Lubiprostone Combined With Maintenance Therapy for Prevention of Postoperative Recurrence in Peritoneal Metast NCT07405736 | Sun Yat-sen University | Phase 2 |
| Recruiting | Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma NCT07463599 | HonorHealth Research Institute | Phase 1 / Phase 2 |
| Not Yet Recruiting | Study of BPI-572270 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS NCT07435038 | Betta Pharmaceuticals Co., Ltd. | Phase 1 / Phase 2 |
| Recruiting | Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors NCT07397338 | Revolution Medicines, Inc. | Phase 1 / Phase 2 |
| Recruiting | A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell NCT07321106 | Cartography Biosciences | Phase 1 |
| Recruiting | Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors NCT07349537 | Revolution Medicines, Inc. | Phase 1 |
| Not Yet Recruiting | Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Qual NCT07346469 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Not Yet Recruiting | CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer NCT06734156 | Gulbenkian Institute for Molecular Medicine | — |
| Recruiting | A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Ca NCT07223047 | Bristol-Myers Squibb | Phase 1 / Phase 2 |
| Recruiting | A Study of ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC NCT07244705 | Anbogen Therapeutics, Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Normobaric Oxygen Therapy in Colorectal Cancer Patients NCT06946004 | 4th Military Clinical Hospital with Polyclinic, Poland | N/A |
| Not Yet Recruiting | How Emotional Granularity Helps Build Resilience in Young and Middle-Aged Colorectal Cancer Survivors NCT07200388 | The Hong Kong Polytechnic University | — |
| Recruiting | A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Canc NCT07011576 | SCRI Development Innovations, LLC | Phase 2 |
| Recruiting | TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery NCT07237438 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Recruiting | Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Su NCT07106892 | Shanghai Henlius Biotech | Phase 2 |
| Enrolling By Invitation | Head to Head Trial of Mailed Cologuard to Mailed FIT NCT06931860 | University of California, San Diego | N/A |
| Recruiting | Clinical Study on the Safety and Preliminary Efficacy of CDH17/GUCY2C CAR-T in the Treatment of Patients With NCT07152210 | Guangzhou Bio-gene Technology Co., Ltd | N/A |
| Recruiting | Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors NCT07151040 | One-carbon Therapeutics AB | Phase 1 / Phase 2 |
| Not Yet Recruiting | MRD-Guided Surveillance in Locally Advanced Mid-Low Rectal Cancer (SURVEILLANCE-III) NCT06879899 | Fudan University | — |
| Not Yet Recruiting | MRD-Guided Surveillance in Operable Colon Adenocarcinoma (I-III)(SURVEILLANCE-I) NCT06879873 | Fudan University | — |
| Not Yet Recruiting | MRD-Guided Surveillance in Resectable Stage IV Metastatic Colorectal Cancer (SURVEILLANCE-II) NCT06879886 | Fudan University | — |
| Not Yet Recruiting | Dual EGFR/HER2 Blockade Combined With Irinotecan for the Treatment of HER2-Positive Metastatic Colorectal Canc NCT07059338 | Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | Fruquintinib vs Bevacizumab Combined With Irinotecan Liposome and Capecitabine as Second-Line Therapy for Adva NCT07051785 | Liu Huang | Phase 2 |
| Recruiting | Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer NCT07046468 | Radboud University Medical Center | — |
| Active Not Recruiting | Neoadjuvant Therapy （NALIRIFOX） for Locally Advanced Colon and Upper Rectal Cancer NCT07020468 | Affiliated Cancer Hospital of Shantou University Medical College | Phase 4 |
| Not Yet Recruiting | Efficacy and Safety of Trifluridine/tipiracil (TAS-102) Combined with Bevacizumab and Putalimab in the Treatme NCT06882915 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 1 |
| Recruiting | Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer NCT06904677 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | — |
| Enrolling By Invitation | Screening With a DNA Blood Test to Address Colorectal Cancer Inequities NCT06929481 | University of California, San Diego | N/A |
| Recruiting | Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associ NCT06919068 | Odense University Hospital | — |
| Not Yet Recruiting | Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lympha NCT06938490 | the BELOOSTROV Clinic of High Technologies | N/A |
| Recruiting | Neoadjuvant Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer NCT06903858 | Sun Yat-sen University | Phase 2 |
| Recruiting | Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS NCT06895031 | Guangzhou JOYO Pharma Co., Ltd | Phase 2 |
| Not Yet Recruiting | Predictive Value of PREMM5, MMRpredict, and Universal Tumor Screening for Lynch Syndrome in Vietnam NCT06863038 | University of Medicine and Pharmacy at Ho Chi Minh City | — |
| Not Yet Recruiting | Trial of Gum Chewing to Enhance the Restoration of Intestinal Motility in Colorectal Cancer Surgery NCT06860685 | Sichuan Cancer Hospital and Research Institute | Phase 1 / Phase 2 |
| Recruiting | Reduce Sedentary Behavior During Cancer Treatment - the RedSedCan Study NCT06719206 | Mälardalen University | N/A |
| Recruiting | Faecal Immunochemical Tests (FIT) for Surveillance After Colorectal Cancer (CRC) Study NCT06689293 | Nottingham University Hospitals NHS Trust | — |
| Recruiting | Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients NCT07114627 | Erasmus Medical Center | — |
| Recruiting | Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions NCT07066046 | Instituto do Cancer do Estado de São Paulo | N/A |
| Recruiting | A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors NCT06789172 | Epkin | Phase 1 |
| Recruiting | Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Deve NCT06809660 | Poitiers University Hospital | N/A |
| Recruiting | mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC NCT06791512 | Jun Huang | Phase 3 |
| Not Yet Recruiting | Fecal Immunochemical Test in Diagnosing Colorectal Cancer Among Vietnamese Patients with Lower Gastrointestina NCT06776120 | Luu Ngoc Mai | N/A |
| Recruiting | Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Ad NCT07035002 | Ruijin Hospital | Phase 1 |
| Recruiting | Clinical Study of IM96 CAR-T Cell Therapy in Patients With Advanced Colorectal Cancer NCT06718738 | Beijing Immunochina Medical Science & Technology Co., Ltd. | Phase 1 |
| Recruiting | Advances in Imaging to Assess Response in Rectal Cancer NCT06822634 | NHS Greater Glasgow and Clyde | — |
| Recruiting | Spatial RadiomIcs and TRanscriptomics to the DIscovery of the Cross-link Between Colon Cancer and ChrOnic Kidn NCT06886282 | National Cancer Institute, Naples | — |
| Recruiting | Evaluation of Gixam's Performance in a FIT Negative Population NCT06612281 | Jubaan Ltd. | Phase 2 |
| Terminated | A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Mono NCT06599502 | AstraZeneca | Phase 1 |
| Not Yet Recruiting | First-line Treatment of MCapOX + Cetuximab Vs. MFOLFOX6 + Cetuximab for RAS/BRAF Wild-type, MSS, Unresectable NCT06616259 | Meng Qiu | Phase 3 |
| Recruiting | Neoantigen-loaded DC Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Treatmen NCT06751940 | The First Affiliated Hospital of Nanchang University | N/A |
| Recruiting | Neoantigen-based Peptide Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Trea NCT06751966 | The First Affiliated Hospital of Nanchang University | N/A |
| Recruiting | Liposomal Irinotecan (II) Fractionated Dosing Combined With 5-FU/LV (FOLFIRInali-3) and Bevacizumab in Second- NCT07047560 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Recruiting | Neoantigen-based Peptide Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Trea NCT06751914 | The First Affiliated Hospital of Nanchang University | N/A |
| Recruiting | Neoantigen-loaded DC Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Treatmen NCT06751953 | The First Affiliated Hospital of Nanchang University | N/A |
| Enrolling By Invitation | Liquid BiOpsy, Lung and Colon Cancer in AndaluciA NCT06997458 | Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental | — |
| Recruiting | Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Met NCT06640166 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Phase 2 |
| Recruiting | Colon Cancer Liquid Biopsy Investigation of Methylation-based Biomarkers Evaluation Using Delta-HLD (CLIMBED) NCT07168876 | Epiliquid Holding, Inc | — |
| Active Not Recruiting | Neoadjuvant Low-dose Immunotherapy in Locally Advanced MMR-deficient Colorectal Cancer NCT07523763 | Blokhin's Russian Cancer Research Center | Phase 2 |
| Recruiting | Improving Colorectal Cancer Early Screening in Portugal: Identification of Gut Microbiome Biomarkers in Stool NCT06741293 | Gulbenkian Institute for Molecular Medicine | — |
| Recruiting | KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors NCT06026410 | Kura Oncology, Inc. | Phase 1 |
| Completed | Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery NCT07423130 | Jagiellonian University | — |
| Recruiting | Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors NCT06040541 | Revolution Medicines, Inc. | Phase 1 |
| Recruiting | TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid NCT04969315 | Portage Biotech | Phase 1 / Phase 2 |
| Recruiting | A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Co NCT05824975 | GI Innovation, Inc. | Phase 1 / Phase 2 |
| Unknown | Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment NCT05648955 | Nutricia Research | EARLY_Phase 1 |
| Recruiting | A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, NCT05706129 | ITM Oncologics GmbH | Phase 1 / Phase 2 |
| Active Not Recruiting | Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Sol NCT05462717 | Revolution Medicines, Inc. | Phase 1 |
| Recruiting | Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis NCT06822413 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α C NCT07197151 | hui hou | — |
| Recruiting | Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS NCT05379985 | Revolution Medicines, Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C NCT05198934 | Amgen | Phase 3 |
| Recruiting | Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors NCT05176483 | Exelixis | Phase 1 |
| Recruiting | Collection of Samples USOPTIVAL Study NCT04792684 | Universal Diagnostics | — |
| Recruiting | Spanish Registry of Digestive Tumours RETUD NCT06711211 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | — |
| Completed | Relative Bioavailability/Bioequivalence of Different Formulations of Selinexor, the Impact of Hepatic Impairme NCT04256707 | Karyopharm Therapeutics Inc | Phase 1 / Phase 2 |
| Recruiting | Advanced Therapies for Liver Metastases NCT04622423 | IRCCS San Raffaele | — |
| Active Not Recruiting | GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors NCT04083599 | Genmab | Phase 1 / Phase 2 |
| Completed | Clinical Characteristics and Prognosis of Simultaneous Versus Delayed Resection for Synchronous Colorectal Liv NCT07082335 | Shanghai 10th People's Hospital | — |
| Completed | A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors NCT03811652 | MedImmune LLC | Phase 1 |
| Completed | A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors NCT03314935 | Incyte Corporation | Phase 1 / Phase 2 |
| Terminated | A Study of SC-007 in Subjects With Advanced Cancer NCT03253185 | AbbVie | Phase 1 |
| Active Not Recruiting | An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxoli NCT02955940 | Incyte Corporation | Phase 2 |
| Completed | Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients NCT02903914 | Incyte Corporation | Phase 1 |
| Completed | Pembrolizumab Combined With Itacitinib (INCB039110) and/or Pembrolizumab Combined With INCB050465 in Advanced NCT02646748 | Incyte Corporation | Phase 1 |
| Active Not Recruiting | Robot-assisted Surgery for Colorectal Cancer Resection: A Population-based Analysis of Prevalence, Trends and NCT06959849 | Medizinische Hochschule Brandenburg Theodor Fontane | — |
| Completed | A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in NCT02327078 | Incyte Corporation | Phase 1 / Phase 2 |
| Unknown | A Novel Patent Platform of Detection of Circulating Tumor Cells to Early Detect Colorectal Cancer Recurrence NCT02005913 | National Taiwan University Hospital | — |
| Completed | Ph II Trial of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Second-line Treatment of NCT00851045 | Bristol-Myers Squibb | Phase 2 |
| Completed | Adherence to a Recommended Exercise Regimen in Colorectal Cancer Patients NCT00977613 | Beth Israel Medical Center | N/A |
| Completed | Study of NGR-hTNF as Single Agent in Patients Affected by Colorectal Cancer (CRC) NCT00483080 | AGC Biologics S.p.A. | Phase 2 |
| Completed | Study of E7070 Combined With Capecitabine to Determine Efficacy and Recommended Dose of Combination in Patient NCT00165854 | Eisai Limited | Phase 2 |
| Completed | A Retrospective Study Comparing the Incidence of Parastomal Hernia After Mesenteric Molding Suturing and Non-m NCT06674200 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Available | Expanded Access Program (EAP) Designed to Provide Access to Botensilimab and Balstilimab Before Regulatory App NCT06751524 | Agenus Inc. | — |