| Not Yet Recruiting | Pulsed Radiofrequency Combined With Platelet-Rich Plasma Applied to the Sphenopalatine Ganglion in Treating Ep NCT06882278 | Beijing Tiantan Hospital | — |
| Recruiting | Efficacy of Light Therapy in Treatment of Chronic Cluster Headache NCT06540651 | Assistance Publique Hopitaux De Marseille | N/A |
| Recruiting | nVNS for the Prevention and Treatment of Primary Headache NCT06277063 | Nanfang Hospital, Southern Medical University | N/A |
| Not Yet Recruiting | A Close Examination of Patient Experiences in Cluster Headache Clinical Research NCT05978258 | Power Life Sciences Inc. | — |
| Completed | Cluster Headache Treatment Survey NCT06011811 | The University of Texas Health Science Center, Houston | — |
| Unknown | Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache NCT05857098 | Assistance Publique Hopitaux De Marseille | — |
| Terminated | Nurse Intervention Trial NCT06200480 | Norwegian University of Science and Technology | N/A |
| Unknown | Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic P NCT05780450 | Fundación Universidad Católica de Valencia San Vicente Mártir | N/A |
| Recruiting | Role of Specific microRNAs in Cluster Headache NCT06503328 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Recruiting | Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial P NCT04930887 | Stanford University | Phase 2 |
| Recruiting | Repeated GON Injections in CCH NCT05324748 | Leiden University Medical Center | Phase 3 |
| Completed | Cluster Headache Treatment With Rimegepant NCT05264714 | Mayo Clinic | Phase 2 |
| Enrolling By Invitation | Quest to Analyze One Thousand Humans Meditating NCT06583395 | Tobias Moeller-Bertram | — |
| Completed | Efficacy of Erenumab in Chronic Cluster Headache NCT04970355 | Charite University, Berlin, Germany | Phase 2 |
| Unknown | Resting State Functional Connectivity in Cluster Headache NCT06206772 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache NCT05153876 | University Hospital, Ghent | — |
| Terminated | High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache NCT04570475 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Treatment of Chronic Cluster Headache with TENS and ONS NCT05023460 | University of Aarhus | N/A |
| Completed | mBrain-21 : a Three-month Study on Context-awareness, Physiological Monitoring, and Machine Learning in Migrai NCT04983186 | University Hospital, Ghent | N/A |
| Completed | The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache NCT04845451 | FARO T. OWIESY, M.D | — |
| Completed | The Effects of Levcromakalim in Patients With Cluster Headache NCT05093582 | Danish Headache Center | N/A |
| Active Not Recruiting | Atrioventricular Block and Cluster Headache (SEVA) NCT04406259 | Centre Hospitalier Universitaire de Nice | Phase 4 |
| Withdrawn | Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache NCT04353505 | Weill Medical College of Cornell University | Phase 1 |
| Terminated | Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH). NCT04439409 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Unknown | Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks NCT04467398 | Seoul National University | — |
| Completed | Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache NCT04949204 | University Hospital, Ghent | — |
| Terminated | Prophylactic Effects of Psilocybin on Chronic Cluster Headache NCT04280055 | Gitte Moos Knudsen | Phase 1 / Phase 2 |
| Completed | Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache NCT04179266 | CCH Pharmaceuticals | Phase 1 / Phase 2 |
| Recruiting | Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headach NCT03944876 | Norwegian University of Science and Technology | Phase 3 |
| Completed | Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Heada NCT04066023 | Zosano Pharma Corporation | Phase 2 / Phase 3 |
| Unknown | Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache NCT04409977 | University of Zurich | — |
| Completed | Risk Taking and Decision-making in Cluster Headache Patients NCT06410872 | Leiden University Medical Center | — |
| Recruiting | Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache NCT03781128 | University Hospital, Basel, Switzerland | Phase 2 |
| Completed | The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache NCT03567590 | Beijing Tiantan Hospital | N/A |
| Enrolling By Invitation | Pain Biomarker Study NCT03511846 | The University of Texas Health Science Center, Houston | Phase 1 |
| Completed | Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache NCT03397563 | St. Olavs Hospital | N/A |
| Unknown | PACAP-38 Infusion in Patients With Cluster Headache NCT03814226 | Danish Headache Center | N/A |
| Unknown | Efficacy and Safety of Zolmitriptan by Sublingual Administration NCT03377257 | Xijing Hospital | Phase 4 |
| Recruiting | China Headache and Vertigo Registry Study NCT04939922 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Terminated | A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster NCT03107052 | Teva Branded Pharmaceutical Products R&D, Inc. | Phase 3 |
| Completed | Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues NCT03066635 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients NCT03010189 | Nordlandssykehuset HF | N/A |
| Completed | Psilocybin for the Treatment of Cluster Headache NCT02981173 | Yale University | Phase 1 |
| Recruiting | The Will Erwin Headache Research Center - Cluster Headache Study NCT02910323 | The University of Texas Health Science Center, Houston | — |
| Completed | Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraph NCT02853487 | Danish Headache Center | — |
| Unknown | Long-term Prognosis of Cluster Headache: a Retrospective Cohort Study NCT02895256 | Samsung Medical Center | — |
| Completed | Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout NCT03439722 | Danish Headache Center | — |
| Unknown | Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache NCT02637648 | Ramin Khatami | Phase 3 |
| Terminated | Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache NCT02381795 | Cady, Roger, M.D. | Phase 2 |
| Completed | CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients NCT02466334 | Danish Headache Center | N/A |
| Unknown | PatientSpot Formerly Known as ArthritisPower NCT03840928 | Global Healthy Living Foundation | — |
| Unknown | Pathway CH S&E Registry NCT02440776 | Autonomic Technologies, Inc. | — |
| Unknown | Physiotherapy Program for Cluster Headache NCT02460003 | AG Clinic | N/A |
| Completed | Cluster Headache, Addictions and Vascular Function NCT02640105 | University Hospital, Bordeaux | — |
| Completed | The Efficacy of L-cysteine in Prevention of Cluster Headache NCT02310828 | Biohit Oyj | N/A |
| Completed | Botox Injection in Treatment of Cluster Headache NCT02019017 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | Intranasal Cooling for Cluster Headache and Migraine NCT01898455 | Cumbria Partnership NHS Foundation Trust | N/A |
| Completed | A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache. NCT01958125 | ElectroCore INC | N/A |
| Completed | Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache NCT01792817 | ElectroCore INC | N/A |
| Completed | Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache NCT01677026 | Autonomic Technologies, Inc. | — |
| Completed | Sleep, Circadian Rhythms and Cluster Headache NCT01447641 | University of Surrey | — |
| Terminated | Saccadometry in Primary Headache Syndromes NCT01395264 | Tim Young | — |
| Terminated | A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache NCT01298921 | Geisinger Clinic | Phase 1 |
| Terminated | Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks NCT00458770 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study NCT03066037 | Charite University, Berlin, Germany | — |
| Completed | Cluster Headache Cortivazol Injection (CHCI) NCT00804895 | Assistance Publique - Hôpitaux de Paris | Phase 2 / Phase 3 |
| Completed | DBS of the Third Ventricle for Cluster Headache and Obesity NCT02782533 | University Hospital, Grenoble | N/A |
| Completed | A Research Study to Examine Cutaneous Allodynia and Cluster Headache NCT00329836 | Thomas Jefferson University | — |
| Completed | Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster NCT00662935 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Prophylactic Treatment of Episodic Cluster Headache NCT00184587 | Norwegian University of Science and Technology | Phase 2 |
| Terminated | A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache NCT00203190 | Thomas Jefferson University | Phase 4 |
| Completed | An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster H NCT00203242 | Thomas Jefferson University | N/A |