NCT04439409

Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH).

AVASNA : Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH).

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 19 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cluster Headache (CH) is associated with ipsilateral vegetative signs, related to parasympathetic system hyperactivity and/or signs of sympathetic hypoactivity. The precise mechanism of Cluster Headache (CH) is still unknown. The question is whether these dysautonomic disorders are simply secondary to the Cluster Headache (CH) process or whether they are the triggering factor.

Detailed description

This study cares about the evolution of the Autonomic Nervous System (ANS) in Cluster Headache (CH) seizures. Patients will be offered Holter ECG to study the temporal relationships between changes in Autonomic Nervous System (ANS) activity during Headache (CH) seizures and changes in Autonomic Nervous System (ANS) activity before and after seizure treatment, using heart rate variability measurement. The hypothesis is that there would be an initial temporary sympathetic activation, followed quickly by parasympathetic hyperactivation and a return to a state of equilibrium.

Conditions

• Cluster Headache

Interventions

Type	Name	Description
DEVICE	Holter electrocardiogram	Holter electrocardiogram will be carried during 7 days to measure heart's electrical activity continuously.

Timeline

• Start date: 2020-08-19
• Primary completion: 2021-12-07
• Completion: 2021-12-15
• First posted: 2020-06-19
• Last updated: 2023-10-27

Locations

1 site across 1 country: France