NCT04409977

Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing systems.

Detailed description

Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes in the functional connectivity, spectroscopy, iron deposition and perfusion of the brain. In addition, we plan to investigate circadian changes in the pain threshold of the brain using quantitative sensory testing (QST). Finally, we will investigate changes in the autonomic nervous system measuring the pupillary response.

Conditions

• Cluster Headache

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI examination	Patient will be scanned in the MRI twice, once at noon (+/- 1 hour), once at 1 a.m. (+/- 1 hour). The investigators will search for any changes in functional connectivity, particular regarding the connection between the hypothalamus and pain-processing networks.

Timeline

• Start date: 2019-06-26
• Primary completion: 2020-06-30
• Completion: 2020-06-30
• First posted: 2020-06-01
• Last updated: 2020-06-01

Locations

1 site across 1 country: Switzerland