NCT02640105

Cluster Headache, Addictions and Vascular Function

Cluster Headache (CH), Addictions and Vascular Function

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 95 (actual)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions. CH has strong links to the vascular system but there is no study measuring endothelial function in CH sufferers.

Detailed description

Several studies have shown an association between Cluster headache (CH) and smoking. However, no data exists on the link between CH and other addictions, and impact of these addictions on clinical characteristics of the disease. In addition, despite the strong biological link between CH and the vascular system, systematic investigations about vascular functions in CH patients are lacking. This will be a prospective cohort study of 150 patients with CH, conducted in the Headache Center in Bordeaux, France.

Conditions

• Cluster Headache

Interventions

Type	Name	Description
OTHER	Neurological clinical examination	Diagnostic and description of cluster headache
OTHER	Psychological clinical examination	Scale and questionnaires
OTHER	Questionnaires	Psychopathological and cognitive questionnaires
OTHER	Blood sample	Blood sample for DNA collection
OTHER	Endothelial function measurement	Endothelial function will be measured with a noninvasive Peripheral Arterial Tone (PAT) signal technology using the EndoPAT device

Timeline

• Start date: 2014-06-25
• Primary completion: 2016-06-10
• Completion: 2016-06-10
• First posted: 2015-12-28
• Last updated: 2022-03-31

Locations

1 site across 1 country: France