| Recruiting | Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmun NCT07284641 | Paul Szabolcs | Phase 2 |
| Enrolling By Invitation | A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive C NCT06559176 | Prime Medicine, Inc. | Phase 1 / Phase 2 |
| Enrolling By Invitation | pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic G NCT06253507 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Unknown | Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel Disease NCT06162936 | National Institute for Mother and Child Health Alessandrescu Rusescu | — |
| Withdrawn | Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations NCT03278912 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Terminated | Whole Blood Biospecimen Collection for Subjects With Chronic Granulomatous Disease (CGD) NCT05915897 | Sanguine Biosciences | — |
| Active Not Recruiting | Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease NCT05600907 | National Institute of Allergy and Infectious Diseases (NIAID) | EARLY_Phase 1 |
| Completed | Baby Detect : Genomic Newborn Screening NCT05687474 | Centre Hospitalier Universitaire de Liege | — |
| Enrolling By Invitation | Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications NCT05104723 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Recruiting | NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) NCT05189925 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Recruiting | Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab NCT05463133 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Completed | Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease NCT03983837 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Active Not Recruiting | Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and NCT03910452 | National Institute of Allergy and Infectious Diseases (NIAID) | EARLY_Phase 1 |
| Completed | Vitamin D3 For CGD Patients With BCGosis/Itis NCT03984890 | Children's Hospital of Fudan University | Phase 2 / Phase 3 |
| Unknown | Plerixafor/G-CSF as Additional Agents for Conditioning Before HSCT in CGD Patients NCT03547830 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | Phase 2 |
| Enrolling By Invitation | Early Check: Expanded Screening in Newborns NCT03655223 | RTI International | — |
| Unknown | Lentiviral Gene Therapy for CGD NCT03645486 | Shenzhen Geno-Immune Medical Institute | N/A |
| Completed | Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation NCT03513328 | University of Florida | Phase 1 / Phase 2 |
| Completed | Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Ex NCT03548818 | University of Colorado, Denver | — |
| Terminated | Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Pa NCT03333486 | Roswell Park Cancer Institute | Phase 2 |
| Terminated | Pioglitazone Therapy for Chronic Granulomatous Disease NCT03080480 | Children's Hospital of Fudan University | Phase 1 / Phase 2 |
| Completed | Effect of IFN-γ on Innate Immune Cells NCT02609932 | University of Colorado, Denver | Phase 1 |
| Completed | IL-1 Receptor Inhibitor for Granulomatous Complications in Patients With Chronic Granulomatous Disease NCT04136028 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | EARLY_Phase 1 |
| Terminated | Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclophosphamide NCT02282904 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Completed | Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995 NCT02116764 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Study of Voicing My CHOiCES as a Tool for Advanced Care Planning in Young Adults With Cancer NCT02108028 | National Cancer Institute (NCI) | — |
| Completed | Bone Marrow Transplant With Abatacept for Non-Malignant Diseases NCT01917708 | Emory University | Phase 1 |
| Completed | Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1 NCT01998633 | Medical College of Wisconsin | Phase 2 |
| Active Not Recruiting | Immune Disorder HSCT Protocol NCT01821781 | Washington University School of Medicine | Phase 2 |
| Active Not Recruiting | Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies NCT01652092 | Masonic Cancer Center, University of Minnesota | N/A |
| Unknown | Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Chronic Gra NCT01338675 | Seoul National University Hospital | Phase 1 / Phase 2 |
| Terminated | Generation of Powerful Biological Tools for Understanding the Pathophysiology of Chronic Granulomatous Disease NCT02926963 | University Hospital, Grenoble | N/A |
| Terminated | Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation NCT01319851 | Emory University | N/A |
| Completed | Pharmacokinetics of Posaconazole in Children With Chronic Granulomatous Disease (CGD) NCT00799071 | Radboud University Medical Center | Phase 2 |
| Terminated | Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells NCT02512679 | Children's Hospital Los Angeles | Phase 2 |
| Withdrawn | Gene Therapy for Chronic Granulomatous Disease in Korea NCT00778882 | Helixmith Co., Ltd. | Phase 1 / Phase 2 |
| Terminated | Gene Therapy for Chronic Granulomatous Disease NCT00394316 | National Institute of Allergy and Infectious Diseases (NIAID) | EARLY_Phase 1 |
| Completed | Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease NCT00368446 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Terminated | Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease NCT00325078 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 / Phase 2 |
| Completed | Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) in Children NCT00927134 | University of Zurich | Phase 1 / Phase 2 |
| Completed | Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease NCT00578643 | Baylor College of Medicine | Phase 2 |
| Completed | Treatment of Chronic Granulomatous Disease With Allogeneic Stem Cell Transplantation Versus Standard of Care NCT00023192 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | Modified Stem Cell Transplantation Procedure for Treating Chronic Granulomatous Disease NCT00006417 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders NCT00005933 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Terminated | Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies NCT00006054 | Fairview University Medical Center | N/A |
| Completed | Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease NCT00001765 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | Diagnostic Effectiveness of Virtual Bronchoscopy NCT00001515 | National Institutes of Health Clinical Center (CC) | Phase 1 |
| Completed | Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-up NCT00001476 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Chil NCT00001317 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 4 |