| Not Yet Recruiting | An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to L NCT05477953 | Bayer | — |
| Recruiting | A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. NCT06632600 | Novartis Pharmaceuticals | Phase 2 |
| Enrolling By Invitation | University-Based Chagas Testing in Salta Province, Argentina NCT07033325 | Mundo Sano Foundation | — |
| Completed | Delivering a Multi-disease Screening Tool to Migrant Populations NCT05868005 | Barcelona Institute for Global Health | N/A |
| Recruiting | Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease NCT04897516 | Laboratorio Elea Phoenix S.A. | Phase 3 |
| Active Not Recruiting | SBRT in Chagas Disease Ventricular Tachycardia NCT04984265 | University of Sao Paulo General Hospital | Phase 1 / Phase 2 |
| Completed | New Therapies and Biomarkers for Chagas Infection NCT03981523 | University of Texas, El Paso | Phase 2 |
| Completed | Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Cha NCT04023227 | Novartis Pharmaceuticals | Phase 4 |
| Active Not Recruiting | Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease NCT04024163 | Insud Pharma | Phase 3 |
| Unknown | Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Disea NCT04084379 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Di NCT03334838 | Bayer | Phase 1 |
| Completed | Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age NCT03672487 | Tulane University School of Public Health and Tropical Medicine | Phase 3 |
| Completed | Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Huma NCT03784391 | Bayer | — |
| Unknown | Colchicine for Patients With Chagas´ Disease( B1 Stage) NCT03704181 | University of Sao Paulo General Hospital | Phase 2 |
| Completed | Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg NCT03350295 | Bayer | Phase 1 |
| Unknown | Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease Treatment NCT04274101 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. NCT03191162 | Hospital Universitari Vall d'Hebron Research Institute | Phase 2 |
| Unknown | BENDITA BEnznidazole New Doses Improved Treatment and Associations NCT03378661 | Drugs for Neglected Diseases | Phase 2 |
| Completed | A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Dise NCT02625974 | Bayer | Phase 3 |
| Completed | Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients NCT02606864 | Bayer | Phase 1 |
| Unknown | CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) NCT02369978 | Universidad Autónoma de Bucaramanga | Phase 2 / Phase 3 |
| Completed | Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy NCT02346123 | Hospital Sao Rafael | — |
| Completed | Physical Exercise Program in Chronic Chagas Heart Disease NCT02517632 | Evandro Chagas National Institute of Infectious Disease | Phase 3 |
| Completed | Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evalua NCT04090489 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | Pharmacokinetic Drug-Drug Interaction Study NCT03892213 | Drugs for Neglected Diseases | Phase 1 |
| Unknown | Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease NCT02498782 | Drugs for Neglected Diseases | Phase 2 |
| Unknown | Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease NCT02099903 | InCor Heart Institute | N/A |
| Completed | Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients NCT01927224 | Bayer | Phase 1 |
| Completed | Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project) NCT02646943 | University of Sao Paulo | — |
| Terminated | Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease NCT01539161 | Medtronic Cardiac Rhythm and Heart Failure | Phase 4 |
| Unknown | Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction NCT02295215 | University of Sao Paulo General Hospital | N/A |
| Completed | Cardiac Rehabilitation in Chagas Heart Failure NCT02516293 | Evandro Chagas National Institute of Infectious Disease | Phase 2 / Phase 3 |
| Completed | New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease NCT01755377 | Barcelona Centre for International Health Research | — |
| Completed | Study Of Nifurtimox Transfer Into Breastmilk In Lactating Women With Chagas Disease NCT01744405 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease NCT01755403 | Barcelona Centre for International Health Research | Phase 4 |
| Completed | Improving Blood Safety and HIV Testing in Brazil NCT01681420 | Vitalant Research Institute | N/A |
| Completed | Abbott ESA Chagas Assay Post-Market Study NCT01662362 | Abbott Diagnostics Division | N/A |
| Completed | Effect of Ganglionar Electrical Stimulation on Central Arterial Pressure NCT01874795 | University of Brasilia | N/A |
| Completed | Study of Benznidazole Transfer Into Breastmilk in Lactating Women With Chagas Disease NCT01547533 | Hospital de Niños R. Gutierrez de Buenos Aires | — |
| Completed | A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) NCT01377480 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease NCT01549236 | Drugs for Neglected Diseases | Phase 4 |
| Completed | Congenital Transmission of Lineages I and II of Trypanosoma Cruzi NCT01787968 | Tulane University School of Public Health and Tropical Medicine | — |
| Completed | Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease NCT01678599 | Drugs for Neglected Diseases | Phase 4 |
| Completed | Galectin-3 as a Biomarker in Patients With Chagas Disease NCT01842854 | Hospital Sao Rafael | — |
| Completed | Syndecan-4 as a Biomarker in Patients With Chagas Disease NCT01842867 | Hospital Sao Rafael | — |
| Completed | Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease NCT02327052 | Hospital Sao Rafael | — |
| Completed | MicroRNAs as Biomarkers in Patients With Chagas Disease NCT01842880 | Hospital Sao Rafael | — |
| Completed | Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole NCT01162967 | Hospital Universitari Vall d'Hebron Research Institute | Phase 2 |
| Completed | Outcomes of an Anticoagulation Clinic in an University Hospital NCT01006486 | Federal University of Minas Gerais | Phase 4 |
| Unknown | Selenium Treatment and Chagasic Cardiopathy (STCC) NCT00875173 | Oswaldo Cruz Foundation | Phase 3 |
| Completed | Population Pharmacokinetics of Benznidazole in Children With Chagas Disease NCT00699387 | Hospital de Niños R. Gutierrez de Buenos Aires | N/A |
| Completed | Exercise Training in Chagas Cardiomyopathy NCT01006473 | Federal University of Minas Gerais | Phase 4 |
| Completed | Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram NCT00453700 | Olive View-UCLA Education & Research Institute | — |
| Completed | BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Diseas NCT00123916 | Population Health Research Institute | Phase 3 |
| Completed | Genetic Architecture of Heart Disease in Rural Brazil NCT00023556 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Tri NCT02386358 | Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben | Phase 3 |
| Completed | Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States NCT00005455 | National Heart, Lung, and Blood Institute (NHLBI) | — |