| Not Yet Recruiting | Enhancing Screening Practices for BE NCT07335445 | Rutgers, The State University of New Jersey | N/A |
| Recruiting | A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk NCT06523374 | University Hospital, Antwerp | N/A |
| Recruiting | Navicam for Detection of Barrett's Esophagus NCT06748911 | Mayo Clinic | N/A |
| Completed | Real-life Prospective Evaluation of Computer-aided Detection (CAD) of Barrett's Neoplasia NCT05965921 | Portsmouth Hospitals NHS Trust | — |
| Recruiting | The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE NCT05818072 | E-DA Hospital | N/A |
| Completed | Detection of Barrett s Esophagus in Patients Without GERD Symptoms NCT04880044 | Case Comprehensive Cancer Center | N/A |
| Unknown | Efficacy and Safety of HYbrid Argon Plasma Coagulation Technique in Patients With Barrett's Esophagus-Related NCT05645679 | Istituto Clinico Humanitas | — |
| Completed | Survey Study on Barrett's Esophagus Screening NCT04408105 | University of Colorado, Denver | — |
| Terminated | Eradicating Barrett's Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Techn NCT03621319 | Erbe Elektromedizin GmbH | N/A |
| Unknown | Application of hybridAPC in the Treatment of Barrett NCT03418584 | Changhai Hospital | N/A |
| Terminated | "Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance NCT02614703 | DHR Health Institute for Research and Development | Phase 2 / Phase 3 |
| Unknown | Radiofrequency Ablation in Patients With Barrett's Esophagus NCT02793479 | Matthias Paireder | — |
| Unknown | Barrett's Dysplasia Detection Pilot Trial Using the NvisionVLE® Imaging System NCT02864043 | NinePoint Medical | N/A |
| Recruiting | Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System NCT02947971 | Massachusetts General Hospital | N/A |
| Completed | pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients Aft NCT02922049 | Institute for Clinical and Experimental Medicine | N/A |
| Completed | Confocal Laser Endomicroscopy vs Conventional Histology for the Identification of Intestinal Metaplasia NCT02632682 | Minnesota Institute for Minimally Invasive Surgery | — |
| Completed | CAlorie and Protein REstriction PROgram in Barrett's Esophagus Patients (CARE-PRO). NCT03813381 | Istituto Oncologico Veneto IRCCS | N/A |
| Completed | Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transitio NCT02579460 | Dallas VA Medical Center | N/A |
| Completed | The Captivator EMR Registry NCT02482701 | Boston Scientific Corporation | — |
| Completed | Cytosponge Adequacy Study Evaluation II NCT02395471 | Medtronic - MITG | N/A |
| Completed | Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome NCT02513784 | Columbia University | N/A |
| Enrolling By Invitation | University of North Carolina (UNC) Barrett's Esophagus and Esophageal Cancer Biorepository NCT02427269 | University of North Carolina, Chapel Hill | — |
| Unknown | Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neopl NCT02464930 | Midwest Biomedical Research Foundation | — |
| Completed | Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium NCT02534233 | Johns Hopkins University | N/A |
| Completed | Efficacy of CryoBalloon Focal Ablation System on Human Esophageal Barrett's Epithelium NCT02249975 | Pentax Medical | N/A |
| Recruiting | TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) NCT02634645 | University of Colorado, Denver | — |
| Completed | Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule NCT02445014 | Massachusetts General Hospital | N/A |
| Completed | Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy NCT02106910 | University of North Carolina, Chapel Hill | N/A |
| Completed | Cryo Balloon for Residual Barrett's Esophagus NCT02230410 | Mayo Clinic | N/A |
| Terminated | Effect of Dexlansoprazole 60 mg QD and 60 mg BID on Recurrence of Intestinal Metaplasia in Subjects Who Have A NCT02162758 | Takeda | Phase 2 |
| Completed | Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe NCT02210039 | Massachusetts General Hospital | N/A |
| Active Not Recruiting | Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule NCT02422433 | Massachusetts General Hospital | N/A |
| Unknown | The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients NCT02149914 | Taichung Tzu Chi Hospital | N/A |
| Recruiting | Australian Barrett's Cohort With Dysplasia and Early Cancer Study NCT02198976 | Professor Michael Bourke | — |
| Completed | Stratifying Risk in Barrett's Esophagus: A Pilot Study for Biomarker-based Patient Management NCT02075905 | University of North Carolina, Chapel Hill | — |
| Completed | Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett's Esophagus Compared With Standard End NCT02066233 | Mayo Clinic | N/A |
| Completed | Confocal Laser Probe to Treat Barrett's Esophagus NCT02852525 | Virendra Joshi | N/A |
| Unknown | Decision Aid for Gastroesophageal Reflux Disease Management NCT01641887 | Massachusetts General Hospital | — |
| Unknown | Patient Registry: Radio Frequency Ablation of Barrett's Esophagus Using HALO System NCT02033070 | Ochsner Health System | — |
| Completed | Comparison of Treatments for Barrett's Esophagus With High-Grade Dysplasia/Early Adenocarcinoma NCT01961778 | Massachusetts General Hospital | N/A |
| Completed | YF476 in Barrett's Esophagus NCT02597712 | Trio Medicines Ltd. | Phase 2 |
| Terminated | A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cr NCT01845454 | CSA Medical, Inc. | N/A |
| Unknown | The Safety and Tolerability of Secretrol in Patients With Barrett's Esophagus NCT01905202 | Effexus Pharmaceutical | Phase 1 |
| Completed | DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma NCT03526328 | University of Oklahoma | — |
| Completed | Prevalence of Dysplasia of the Gastric Cardia NCT01787864 | University of North Carolina, Chapel Hill | — |
| Completed | Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids NCT01733147 | Mayo Clinic | Phase 4 |
| Suspended | Narrow Band Imaging Project on Barrett's Esophagus NCT01580631 | Midwest Biomedical Research Foundation | — |
| Unknown | Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma NCT02018367 | Anandasabapathy, Sharmila, M.D. | Phase 2 |
| Completed | A In-Vivo Esophageal Protocol for Detection of Neoplasia in the Digestive Tract NCT01630798 | University of Michigan | Phase 1 |
| Completed | Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Pr NCT01913223 | Hospices Civils de Lyon | N/A |
| Completed | Gene Methylation in the Diagnosis of Barrett's Esophagus: Identification of Candidate Diagnostic Markers NCT02066701 | Mayo Clinic | — |
| Completed | Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study NCT01566474 | Aragon Institute of Health Sciences | Phase 3 |
| Completed | Study to Image the Esophagus Using the OFDI Capsule NCT02204150 | Massachusetts General Hospital | N/A |
| Completed | Betrnet Stem Cells and the Origins of Barrett's Esophagus Project 3 RF Ablation NCT01568723 | Mayo Clinic | — |
| Completed | High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE) NCT01503411 | NinePoint Medical | — |
| Completed | Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Barrett's Epithelium NCT01633411 | Pentax Medical | — |
| Completed | BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus NCT01484925 | Abramson Cancer Center at Penn Medicine | — |
| Terminated | Endoscopic Resection or Ablation for Patients With Dysplasia or Cancer Requiring Treatment of Barrett's Esopha NCT01572987 | Midwest Biomedical Research Foundation | N/A |
| Completed | Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia NCT01384864 | Anandasabapathy, Sharmila, M.D. | EARLY_Phase 1 |
| Terminated | Polar Wand Carbon Dioxide Cryotherapy for Barrett's Esophagus NCT01477177 | Mayo Clinic | N/A |
| Unknown | Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders NCT01438385 | Weill Medical College of Cornell University | — |
| Completed | Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus? NCT01373125 | University of North Carolina, Chapel Hill | — |
| Completed | Racial Disparity in Barrett's Esophagus NCT01374074 | University of North Carolina, Chapel Hill | — |
| Terminated | High Definition White Light Endoscopy and Narrow Band Imaging for the Assessment of Barrett's Disease After En NCT01360801 | Mayo Clinic | — |
| Completed | Comparative Effectiveness of Endoscopic Assessment of Gastroesophageal Reflux and Barretts Esophagus NCT01288612 | Mayo Clinic | N/A |
| Completed | Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium NCT01293448 | Pentax Medical | N/A |
| Completed | The Role of the Fujinon Intelligent Chromo Endoscopy (FICE™) in Barrett's Esophagus NCT01084629 | Mayo Clinic | — |
| Completed | Optical Frequency Domain Imaging (OFDI) Surveillance and Image Guided Biopsy of the Esophagus NCT01439633 | Massachusetts General Hospital | N/A |
| Completed | Early Increase in Blood Supply in Patients With Barrett's Esophagus NCT01188980 | Mayo Clinic | — |
| Completed | Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus NCT01298999 | Columbia University | Phase 2 |
| Completed | Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Abl NCT01093755 | Mayo Clinic | Phase 4 |
| Completed | CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia NCT01032044 | Mauna Kea Technologies | N/A |
| Completed | To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use NCT01306799 | University of Pennsylvania | — |
| Terminated | Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease NCT01572974 | Midwest Biomedical Research Foundation | — |
| Completed | Epidemiology of Barrett's Esophagus: A Population Based Study NCT01286155 | Mayo Clinic | — |
| Completed | Endoscopic Detection of Dysplasia in Barrett's Esophagus NCT01694511 | Göteborg University | N/A |
| Completed | Expression and Function of the Renin-Angiotensin System in the Esophagus NCT02879721 | Göteborg University | EARLY_Phase 1 |
| Terminated | Imaging Enhanced Endoscopy for the Screening of Barrett's Esophagus NCT01976351 | National Taiwan University Hospital | — |
| Terminated | A Feasibility Study of Confocal Microendoscopy in the Evaluation of Gastrointestinal Neoplasia -Project 1 NCT01384695 | Anandasabapathy, Sharmila, M.D. | EARLY_Phase 1 |
| Completed | CryoSpray Ablation (TM) GI Patient Registry NCT00747448 | CSA Medical, Inc. | — |
| Completed | The Efficacy and Patient Tolerance of Ultrathin Nasal Endoscopy to Detect Barrett's Oesophagus NCT02498041 | University of Cambridge | N/A |
| Unknown | Acetic Acid Guided Biopsies Compared With High Definition Endoscopy in the Detection of Barrett's Esophagus NCT01442506 | Johannes Gutenberg University Mainz | — |
| Completed | Evaluation of a Miniaturized Microscope Device for the Detection of Barrett's Neoplasia: A Pilot Study NCT01384227 | Anandasabapathy, Sharmila, M.D. | EARLY_Phase 1 |
| Completed | Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophag NCT00754468 | CSA Medical, Inc. | Phase 4 |
| Completed | Barrett's Esophagus in Olmsted County NCT00943280 | Mayo Clinic | — |
| Completed | Detection Of Neoplastic Tissue in Barrett's Esophagus With In vivO Probe-based Confocal Endomicroscopy NCT00795184 | Mauna Kea Technologies | N/A |
| Completed | Optical Frequency Domain Imaging (OFDI) Assessment in Radiofrequency Ablation NCT01439594 | Massachusetts General Hospital | N/A |
| Completed | Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus NCT01281618 | Mayo Clinic | — |
| Terminated | WavSTAT® Optical Biopsy System to Target Esophageal Biopsies NCT00747136 | SpectraScience | — |
| Terminated | A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies NCT01030263 | Mayo Clinic | Phase 4 |
| Completed | Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue NCT00909350 | Mayo Clinic | — |
| Terminated | Study of Endoscopic Barrett's Esophagus Diagnosis NCT00591461 | Oregon Health and Science University | — |
| Completed | PillCam® ESO 2 in Esophageal Pathologies NCT00885469 | Medtronic - MITG | — |
| Terminated | The Study of Barrett's Esophagus: What Are the Factors of Progression NCT00586404 | Midwest Biomedical Research Foundation | — |
| Completed | Preliminary Longitudinal Validation of Biomarkers Predictive of Barrett's Esophagus NCT00844077 | University of Michigan | — |
| Completed | Endoscopic Mucosal Resection (EMR) in Barrett's Esophagus NCT00586872 | Mayo Clinic | — |
| Terminated | Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus NCT00526786 | CSA Medical, Inc. | Phase 4 |
| Completed | Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus NCT00573911 | Mayo Clinic | Phase 1 |
| Completed | Barrett's Esophagus & Gastroesophageal Reflux Disease NCT00513331 | Valley Health System | — |
| Recruiting | Barrett's Esophagus Related Neoplasia (BERN) Project NCT00590239 | Midwest Biomedical Research Foundation | — |
| Completed | Confocal Endomicroscopy for Barrett's Esophagus NCT00487695 | Johns Hopkins University | Phase 3 |
| Unknown | Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer NCT00628784 | Walter Reed Army Medical Center | Phase 4 |
| Completed | Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction NCT01401699 | Massachusetts General Hospital | N/A |
| Terminated | APE-Study: Ablation of Barrett's Mucosa vs. Surveillance Without Ablation in Patients Cured From Barrett's Can NCT00546065 | HSK Wiesbaden | N/A |
| Completed | Confocal Microscopy in Barrett's Esophagus NCT00587184 | Mayo Clinic | — |
| Unknown | The Effect of Nexium on Transmucosal Esophageal Leak NCT00216788 | Main Line Health | Phase 1 |
| Recruiting | Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registr NCT00574327 | Midwest Biomedical Research Foundation | — |
| Completed | An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients NCT00352261 | AstraZeneca | Phase 4 |
| Recruiting | Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma NCT00288119 | Case Western Reserve University | — |
| Completed | Ramanspectroscopy in Barrett's Esophagus NCT00588575 | Mayo Clinic | — |
| Completed | Early Detection of Barrett's Esophagus NCT00081354 | National Cancer Institute (NCI) | — |
| Enrolling By Invitation | The Effect of Ablation Therapy on Barrett's Esophagus NCT00587314 | Mayo Clinic | — |
| Completed | Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity F NCT01238042 | Roswell Park Cancer Institute | Phase 1 |
| Completed | Biomarkers in Phototherapy of Barrett's Esophagus NCT00587600 | Mayo Clinic | Phase 2 / Phase 3 |
| Completed | Barrett's Esophagus - 315 - 3 Way Cross Over NCT00637988 | AstraZeneca | Phase 4 |
| Completed | Barrett's Esophagus - 315 - 3 Way Cross-Over NCT00637559 | AstraZeneca | Phase 4 |
| Completed | Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) NCT00872755 | G. Hatzikosta General Hospital | Phase 4 |
| Completed | Study of Photodynamic Therapy (PDT) Using HPPH in Barrett's Esophagus NCT01236443 | Roswell Park Cancer Institute | Phase 1 |
| Withdrawn | Case Analysis on Real Life Incidence of Photodynamic Therapy (PDT) Safety Outcomes NCT01203163 | Pinnacle Biologics Inc. | — |