NCT01439594

Optical Frequency Domain Imaging (OFDI) Assessment in Radiofrequency Ablation

Pilot Study to Evaluate Optical Frequency Domain Imaging as a Tool for Assessing the Tissue Response to Radiofrequency Ablation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this research is to conduct a pilot clinical study to evaluate the potential use of esophageal Optical Frequency Domain Imaging (OFDI) for assessing the success and degree of injury associated with therapeutic radiofrequency ablation techniques.

Detailed description

This is a single center pilot study conducted in 30 patients scheduled for therapeutic intervention. As the purpose of the study is to assess the response of the esophagus to radio frequency (RF) ablation, and the degree of residual Barrett's Esophagus (BE) remaining following treatment, OFDI imaging of study participants will occur prior to the scheduled BARRX RF treatment, and at the standard 3 and 6 month follow-up visits. Following initial visual surveillance of the esophagus, the study experimental procedure will begin. Imaging will be performed with the OFDI system in 4 longitudinal (\~5cm) volumetric segments that are spaced equally circumferentially along the esophagus in a similar fashion to the standard 4-quadrant biopsy protocol. Each of the 4 OFDI imaging segments will be acquired in less than 1 minute.

Conditions

• Barrett's Esophagus

Interventions

Type	Name	Description
DEVICE	MGH OFDI Imaging	Imaging of Esophagus with OFDI system

Timeline

• Start date: 2008-10-01
• Primary completion: 2014-03-01
• Completion: 2014-03-01
• First posted: 2011-09-23
• Last updated: 2019-11-22
• Results posted: 2019-11-22

Locations

1 site across 1 country: United States