| Not Yet Recruiting | Zynrelef Versus Adductor Canal Block NCT07216586 | University of Miami | Phase 4 |
| Recruiting | Precision of Pacient-specific Instrumented Open Wedge High Tibial Osteotomy vs Conventional Technicque NCT07212777 | University of Malaga | N/A |
| Withdrawn | The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty NCT06489626 | F. Johannes Plate | Phase 4 |
| Active Not Recruiting | Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With NCT07391592 | MicroPort Orthopedics Inc. | — |
| Not Yet Recruiting | Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health NCT06907121 | Integrant Pty Ltd | Phase 2 / Phase 3 |
| Enrolling By Invitation | Health Coaching for Patients Waiting for Total Hip or Knee Replacements NCT06596031 | Sheffield Hallam University | N/A |
| Not Yet Recruiting | Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic an NCT06709703 | Université de Sherbrooke | N/A |
| Withdrawn | Robotic Assisted Knee Arthroplasty - Retain the Anterior Cruciate Ligament or Not NCT06264999 | St. Olavs Hospital | N/A |
| Recruiting | Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Trans NCT06522152 | Istituto Ortopedico Rizzoli | — |
| Recruiting | Total Versus Robotic Assisted Unicompartmental Knee Replacement NCT05290818 | NHS Lothian | N/A |
| Completed | Risk of Revision Following Knee Arthroplasty in Bariatric Surgery Patients NCT06433700 | Bispebjerg Hospital | — |
| Completed | The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA NCT06112548 | Damascus University | N/A |
| Recruiting | Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery NCT05957822 | Konkuk University Medical Center | Phase 4 |
| Recruiting | Developing an Opioid Taper Intervention Before Total Joint Arthroplasty NCT05788016 | University of Alabama at Birmingham | N/A |
| Completed | Persistent Pain After Knee Replacement NCT05900791 | University Hospital Bispebjerg and Frederiksberg | — |
| Unknown | Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties NCT06024161 | Bispebjerg Hospital | — |
| Unknown | Muscles Strength and Gait Parameteres After TKA NCT06061367 | Medical University of Warsaw | — |
| Recruiting | Functional Recovery After Total Knee Arthroplasty NCT06821269 | University of Pittsburgh | — |
| Completed | Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia NCT05760534 | Seoul National University Hospital | Phase 4 |
| Unknown | Quantitative Assessment of Walking (Squawk) With the Canary canturioTM te (CTE) Tibial Extension NCT05693818 | Canary Medical | — |
| Unknown | Dextrose Prolotherapy on Articular Cartilage NCT06301958 | Chang Gung Memorial Hospital | N/A |
| Completed | Assessing Function and Pain After Total Knee Arthroplasty With Combined Femoral and Popliteal Nerve Block NCT06196359 | University of Haifa | N/A |
| Unknown | Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Tot NCT05476367 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | The Effect of Stress on the Residual Gastric Volume NCT05406245 | Seoul National University Bundang Hospital | — |
| Completed | Heat Application to Quadriceps Effect on Pain After a Total Knee Arthroplasty NCT05462483 | The Idaho Clinic | N/A |
| Enrolling By Invitation | Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With NCT04816773 | MicroPort Orthopedics Inc. | — |
| Completed | Bioavailability of Intranasal Dexmedetomidine NCT05065775 | Turku University Hospital | Phase 4 |
| Completed | The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study NCT04956393 | University of British Columbia | N/A |
| Completed | Gastric Volume in Elderly Patients Undergoing Staged Bilateral Total Knee Arthroplasty NCT04814706 | Seoul National University Bundang Hospital | — |
| Completed | Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA NCT05696418 | Damascus University | N/A |
| Completed | Effectiveness of Client-centered Intervention in After Total Knee Arthroplasty NCT04969432 | Saglik Bilimleri Universitesi | N/A |
| Completed | Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA NCT05691751 | Damascus University | N/A |
| Terminated | Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilater NCT04712019 | Solventum US LLC | N/A |
| Completed | How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Tot NCT04648072 | Health Sciences North Research Institute | N/A |
| Completed | Tourniquet on Total Knee Arthroplasty NCT04923724 | Washington University School of Medicine | N/A |
| Completed | Efficacy of iPACK After Unilateral TKA NCT04565093 | King Khalid University Hospital | N/A |
| Unknown | The Establishment of Total Joint Arthroplasty Registry Database NCT04479462 | Chang Gung Memorial Hospital | — |
| Withdrawn | Univation XM France NCT04199481 | Aesculap AG | — |
| Not Yet Recruiting | Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty NCT04432259 | Henry Ford Health System | Phase 4 |
| Completed | Exparel Use in Adductor Canal Block After Total Knee Arthroplasty NCT04910165 | St. Luke's Hospital, Pennsylvania | Phase 3 |
| Completed | Intraosseous Morphine in Primary TKA NCT04388111 | The Methodist Hospital Research Institute | Phase 4 |
| Unknown | Prevalence of Coronal Femoral Bowing in the Egyptian Arthritic Knee NCT03874468 | Kerolos Naiem Shehata Rofael | — |
| Withdrawn | Comparing Pain and Kinematic Outcomes of Two Gait-Modifying Shoe Interventions NCT03760380 | University of Florida | N/A |
| Withdrawn | Assessing if Cryoneurolysis Improves Prehabilitation and Decreases Pain After Surgery With Less Opioid Use in NCT03836313 | Brigham and Women's Hospital | N/A |
| Unknown | Validation of Consumer Activity Monitors in Postoperative Total Arthroplasty Patients NCT03958370 | Benaroya Research Institute | — |
| Unknown | Prediction Model of Acute Postoperative Pain in Bilateral Total Knee Replacement Arthroplasty Patient NCT03765723 | Seoul National University Hospital | — |
| Withdrawn | Preoperative Radiographic Evaluation of Medial Tibiofemoral Knee Osteoarthritis NCT03704558 | Rennes University Hospital | — |
| Completed | Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Tri NCT04441112 | Saint Alphonsus Regional Medical Center | Phase 2 / Phase 3 |
| Completed | Study of Hip and Knee Arthroplasty in South Africa NCT03540667 | University of Cape Town | — |
| Terminated | Magnesium and Postoperative Pain NCT03253224 | Seoul National University Hospital | Phase 4 |
| Completed | Retrospective Simplex High Viscosity (HV) Bone Cement Study NCT05659329 | Stryker Orthopaedics | — |
| Completed | Feasibility of Multi-modal Physical Therapy in Latino Older Adults With Moderate Knee Osteoarthritis NCT04219423 | Kaiser Permanente | N/A |
| Completed | Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Repla NCT02288923 | Royal Devon and Exeter NHS Foundation Trust | N/A |
| Completed | Anti Inflammatory Effects of Local Cryotherapy in Knee Arthritis NCT03850392 | Centre Hospitalier Universitaire de Besancon | N/A |
| Completed | Supporting Decision Making for Musculoskeletal Preference-Sensitive Care NCT01345123 | Health Dialog | N/A |