NCT04441112

Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Saint Alphonsus Regional Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Conditions

• Arthritis Knee
• Arthritis of Hip

Interventions

Type	Name	Description
DRUG	Ketorolac Intraarticular Injection	Injections will be given under ultrasound guidance with one of two possible medications.
DRUG	Triamcinolone Intraarticular Injection	Injections will be given under ultrasound guidance with one of two possible medications.

Timeline

• Start date: 2018-05-20
• Primary completion: 2019-08-20
• Completion: 2019-08-20
• First posted: 2020-06-22
• Last updated: 2020-06-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study