NCT06489626

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: F. Johannes Plate · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in controlling acute pain following total knee arthroplasty. This study aims to evaluate the effect of a post-operative steroid (methylprednisolone) taper in improving functional and patient-reported outcomes following total knee arthroplasty. A taper means taking a high dose of a medication followed by taking lower doses and each following day until the medication is stopped.

Conditions

• Arthritis Knee
• Knee Osteoarthritis
• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Methylprednisolone 4 milligram Tab	6-day 4 milligram methylprednisolone oral taper
DRUG	Dexamethasone injection	4 milligram intravenous dexamethasone will be administered intraoperatively

Timeline

• Start date: 2025-11-01
• Primary completion: 2027-10-01
• Completion: 2027-12-01
• First posted: 2024-07-08
• Last updated: 2026-02-05

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study