| Not Yet Recruiting | An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patient NCT07377981 | The First Affiliated Hospital with Nanjing Medical University | Phase 4 |
| Recruiting | A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease NCT06937229 | Bristol-Myers Squibb | Phase 3 |
| Recruiting | Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's NCT06052254 | Teikoku Pharma USA, Inc. | Phase 2 |
| Not Yet Recruiting | Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery NCT07051096 | University of British Columbia | N/A |
| Recruiting | Detection of Risk Behaviors: Pilot Observational Study With Bedridden and Agitated Patients. NCT05522647 | University Hospital, Clermont-Ferrand | — |
| Not Yet Recruiting | Comparison of Haloperidol and Dexmedetomidine for Delirium and Agitation in ICU Patients With Traumatic Brain NCT06993194 | Benha University | N/A |
| Recruiting | Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Part NCT06808984 | Celgene | Phase 2 |
| Recruiting | Acute Agitation in Emergency Psychiatry NCT06752616 | Lone Baandrup | Phase 2 / Phase 3 |
| Recruiting | Neurosteer Bedside Monitoring System NCT06718764 | Icahn School of Medicine at Mount Sinai | N/A |
| Active Not Recruiting | Life's End Benefits of cannaBidiol and tetrahYdrocannabinol NCT05644262 | University of Southern California | Phase 2 |
| Completed | Doll Therapy for Agitated Elderly Dementia People NCT06578819 | Karadeniz Technical University | N/A |
| Withdrawn | Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in t NCT05974527 | Brigham and Women's Hospital | Phase 4 |
| Unknown | A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD) NCT06140342 | Autotune Me LLC | — |
| Unknown | Premature Enhanced Automated Capture of Comfort Knowledge NCT06037629 | Newcastle University | — |
| Terminated | Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III) NCT05665088 | BioXcel Therapeutics Inc | Phase 3 |
| Recruiting | Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type NCT05397639 | Suven Life Sciences Limited | Phase 3 |
| Completed | A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Alzheimer's Disease Agitation NCT05557409 | Axsome Therapeutics, Inc. | Phase 3 |
| Completed | Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II) NCT05271552 | BioXcel Therapeutics Inc | Phase 3 |
| Unknown | Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatrics NCT05273671 | Alexandria University | Phase 4 |
| Terminated | An Efficacy, and Safety Study Of BXCL501 For The Treatment Of Agitation Associated With Dementia NCT05276830 | BioXcel Therapeutics Inc | Phase 2 |
| Unknown | The Effectiveness of Acupuncture for Complications in Critically Ill Patients NCT04950738 | China Medical University Hospital | N/A |
| Completed | Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine NCT04908605 | Ain Shams University | Phase 4 |
| Completed | Midazolam Effect on Agitation Postnasal Surgery NCT05165914 | Jordanian Royal Medical Services | N/A |
| Completed | Music and Essential Oil in Agitation NCT04722614 | Alexandria University | N/A |
| Withdrawn | Study of BXCL501 In Agitation Associated With Delirium in ICU Patients NCT05313386 | BioXcel Therapeutics Inc | Phase 2 |
| Recruiting | Nabilone for Agitation Blinded Intervention Trial NCT04516057 | Sunnybrook Health Sciences Centre | Phase 3 |
| Completed | Different Premedication in Pediatric Patients NCT04266340 | Eye & ENT Hospital of Fudan University | N/A |
| Unknown | The Effectiveness of Acupuncture for Delirium in Critically Ill Patients NCT04312893 | China Medical University Hospital | N/A |
| Completed | Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia NCT04268303 | BioXcel Therapeutics Inc | Phase 3 |
| Completed | Sub-Lingual Dexmedetomidine in Agitation Associated With Schizophrenia NCT04010305 | BioXcel Therapeutics Inc | Phase 1 |
| Completed | TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting NCT03639558 | Joseph Dib | Phase 4 |
| Completed | Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care Units NCT03773874 | Hospital Universitario Getafe | — |
| Unknown | Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery NCT03398759 | RenJi Hospital | N/A |
| Completed | Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial) NCT03317067 | University Hospital, Clermont-Ferrand | Phase 3 |
| Completed | Ketamine Versus Midazolam for Prehospital Agitation NCT03554915 | Hennepin Healthcare Research Institute | — |
| Terminated | A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression NCT03044249 | Mediti Pharma Inc. | Phase 2 |
| Terminated | Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients. NCT02846740 | University of Maryland, Baltimore | N/A |
| Completed | Phase IV to Evaluate the Safety of Self-administered ADASUVE® in Agitated Patients Outside the Hospital Settin NCT02525991 | Ferrer Internacional S.A. | Phase 4 |
| Completed | Helping Older Persons Emerge Stronger NCT02863081 | Ohio State University | — |
| Completed | Comparison of Ketamine-propofol Combinations NCT02848963 | Cukurova University | Phase 4 |
| Completed | Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Children NCT02720705 | Assiut University | Phase 2 / Phase 3 |
| Unknown | Naturalistic Adasuve Clinical Trial Study NCT02877108 | Mt Sinai Hospital, Chicago | — |
| Unknown | Effects of Preoperative Using of Eye Patches on Prevention of Emergence Agitation After Cataract Surgery NCT02590744 | Xiaoliang Gan | N/A |
| Completed | Scalp Nerve Block on Emergence Agitation NCT02428283 | Ajou University School of Medicine | Phase 4 |
| Completed | Safety and Efficacy of Nabilone in Alzheimer's Disease NCT02351882 | Sunnybrook Health Sciences Centre | Phase 2 / Phase 3 |
| Completed | Learning Oriented Physiotherapy - a New Approach NCT02194036 | Helse Nord-Trøndelag HF | N/A |
| Completed | Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure NCT02203019 | Texas Tech University Health Sciences Center | Phase 4 |
| Completed | Treatment of Psychosis and Agitation in Alzheimer's Disease NCT02129348 | New York State Psychiatric Institute | Phase 2 |
| Unknown | Effect of Deksmedetomidine and Remifentanil in Extubation Agitation NCT02104297 | Diskapi Yildirim Beyazit Education and Research Hospital | Phase 4 |
| Unknown | A Naturalistic Two-year Cohort Study of Agitation and Quality of Life in Care Homes NCT02216396 | University College, London | — |
| Withdrawn | Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital NCT02103881 | Hennepin Healthcare Research Institute | Phase 4 |
| Unknown | Long Term Memory Preoperative Preparation Reduce Post Operative Behavioral Change NCT04039269 | Prince of Songkla University | N/A |
| Unknown | Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation. NCT02164773 | Ain Shams University | Phase 4 |
| Completed | Safety Study of Dexmedetomidine in Septic Patients NCT01976754 | First Affiliated Hospital of Zhejiang University | N/A |
| Completed | Dexmedetomidine to Prevent Agitation After Free Flap Surgery NCT01904760 | Peking University | Phase 4 |
| Completed | Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit NCT01848158 | Seattle Children's Hospital | N/A |
| Completed | Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency De NCT01747824 | Hennepin Healthcare Research Institute | — |
| Completed | Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of A NCT01584440 | Avanir Pharmaceuticals | Phase 2 |
| Completed | Agitation in Post Operative Neurosurgical Patients NCT00590499 | Capital Medical University | — |
| Completed | Treating Acutely Agitated Patients With Asenapine Sublingual Tablets NCT01400113 | Unity Health Toronto | Phase 4 |
| Completed | Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for t NCT01501123 | Catholic Health East | N/A |
| Completed | Effect of Single-dose Dexmedetomidine on Emergence Excitement in Adults With Nasotracheal Intubation After Ort NCT01524367 | Yonsei University | Phase 4 |
| Completed | Continuing Education in Nursing Home Dementia Care NCT01715506 | Bergen University College | N/A |
| Unknown | ED50 of Dexmedetomidine to Prevent Emergence Agitation in Children NCT01374737 | Seoul National University Hospital | Phase 4 |
| Withdrawn | Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patient NCT02118688 | Rochester General Hospital | Phase 4 |
| Completed | Effects of Serotonin Inhibitors on Patient-controlled Analgesia Related Nausea and Vomiting NCT01517438 | Seoul National University Hospital | N/A |
| Completed | Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia NCT01856010 | Pine Rest Christian Mental Health Services | — |
| Completed | Person- Centred Care Among Nursing Home Patients With Dementia NCT01280890 | Norwegian Centre for Ageing and Health | N/A |
| Completed | The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer's Disease NCT01329536 | Avera McKennan Hospital & University Health Center | — |
| Completed | Collaboration Between Department of Old Age Psychiatry and Nursing Homes NCT01217541 | Sykehuset Innlandet HF | N/A |
| Completed | The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients Afte NCT01440114 | Prince of Songkla University | N/A |
| Completed | Pain in Patients With Dementia and Behavioural Disturbances NCT01021696 | University of Bergen | Phase 2 / Phase 3 |
| Completed | Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children NCT00857727 | St. Luke's-Roosevelt Hospital Center | Phase 3 |
| Completed | Citalopram for Agitation in Alzheimer's Disease NCT00898807 | JHSPH Center for Clinical Trials | Phase 3 |
| Completed | A Study To Evaluate The Efficacy And Safety Of Intramuscular Levosulpiride In Patients With Agitation Of Schiz NCT00866645 | Shanghai Mental Health Center | Phase 2 / Phase 3 |
| Withdrawn | Ziprasidone vs Standard Therapy for Agitated Patients in the ED NCT00786318 | George Washington University | Phase 4 |
| Terminated | Haloperidol vs Olanzapine for the Management of ICU Delirium NCT00833300 | Richard Hall | N/A |
| Completed | Escitalopram Treatment for BPSD in Alzheimer's Disease in Comparison to Risperidone NCT01119638 | Abarbanel Mental Health Center | Phase 4 |
| Completed | Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia NCT00797277 | National Taiwan University Hospital | Phase 3 |
| Terminated | Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With NCT00315900 | Tuscaloosa Research & Education Advancement Corporation | Phase 3 |
| Completed | A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room NCT00457366 | University of Southern California | Phase 4 |
| Completed | Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium NCT00351299 | Brigham and Women's Hospital | Phase 2 |
| Completed | A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitatio NCT00505804 | Austin Health | Phase 2 |
| Completed | Antipsychotic Discontinuation in Alzheimer's Disease NCT00417482 | New York State Psychiatric Institute | Phase 4 |
| Completed | Quality Improving Program on Agitation in the Surgical Intensive Care Unit NCT02199262 | University Hospital, Geneva | N/A |
| Completed | Liquid Risperidone in the Treatment of Acute Agitation in Psychiatrically Hospitalized Children NCT00790075 | Stony Brook University | Phase 4 |
| Completed | Treatment of Behavioral Symptoms in Alzheimer's Disease NCT00009217 | New York State Psychiatric Institute | Phase 4 |