| Recruiting | Establishment and Clinical Application of Reference Intervals of Salivary Cortisol NCT07168122 | Shanghai 6th People's Hospital | — |
| Not Yet Recruiting | Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Imp NCT06980753 | University of Sao Paulo General Hospital | N/A |
| Completed | Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function NCT06608433 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent Wit NCT06955286 | Qifu Li | — |
| Not Yet Recruiting | Treatment Study in Patients Treated With Both Insulin & Hydrocortisone NCT05716607 | Vastra Gotaland Region | N/A |
| Not Yet Recruiting | Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatrics NCT06435481 | Hospital Universitari Vall d'Hebron Research Institute | Phase 4 |
| Recruiting | A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemi NCT06861530 | University Children's Hospital Basel | — |
| Recruiting | A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement NCT06430528 | University of Michigan | — |
| Unknown | Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP) NCT06148090 | University Hospital, Bordeaux | N/A |
| Unknown | Diagnosis of Adrenal Insufficiency in Liver Cirrhosis Patients NCT06206655 | Seoul National University Hospital | — |
| Unknown | Feasibility and Validation of the Fluispotter®, a Novel Intravenous System for Serial Blood Sampling NCT05931926 | Rigshospitalet, Denmark | — |
| Completed | Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure NCT05806190 | Imperial College Healthcare NHS Trust | — |
| Unknown | Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care Unit NCT05741762 | Dr Adnan Agha | — |
| Unknown | Residual Adrenal Function in Addison's Disease NCT06309498 | Istituto Auxologico Italiano | — |
| Unknown | The Treatment of Adrenal Crisis With Inhaled Prednisolone NCT05639127 | University Medical Center Groningen | EARLY_Phase 1 |
| Recruiting | Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency NCT05435781 | Marianne Christina Klose | Phase 4 |
| Recruiting | Updated Diagnostic Cortisol Values for Adrenal Insufficiency NCT05149638 | Montefiore Medical Center | N/A |
| Recruiting | Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoi NCT05193396 | Marianne Andersen | Phase 4 |
| Unknown | Impact of Exogenous Estrogens on Cotisol Levels During Synacthen Stimulation NCT05302726 | Rigshospitalet, Denmark | N/A |
| Unknown | Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids NCT06008184 | Centre Hospitalier Universitaire Vaudois | — |
| Completed | Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis NCT04642391 | University of Virginia | — |
| Completed | Neonatal, Infant and Toddler Salivary Study (NITS Study) NCT05350982 | Sheffield Children's NHS Foundation Trust | — |
| Completed | Assessment of Diurnal Salivary Cortisol Production in COVID-19 NCT04988269 | National and Kapodistrian University of Athens | — |
| Completed | Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men NCT05806723 | Hopital La Rabta | Phase 4 |
| Completed | The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course. NCT05070091 | Medical University of Gdansk | — |
| Completed | Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone. NCT05457296 | University Tunis El Manar | Phase 4 |
| Unknown | Hydrocortisone Use During Peri-operation for Pituitary Adenomas NCT04621565 | Peking Union Medical College Hospital | N/A |
| Active Not Recruiting | Improved Diagnostics and Monitoring of Polymyalgia Rheumatica NCT04519580 | Kresten Krarup Keller | — |
| Recruiting | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Stan NCT04278404 | Duke University | — |
| Completed | Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant NCT04488432 | University Hospital, Brest | — |
| Unknown | Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study) NCT03936517 | Imperial College London | Phase 3 |
| Withdrawn | Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers NCT03752190 | Johns Hopkins University | Phase 4 |
| Completed | Rheumatoid Arthritis Adrenal Recovery Study NCT03294876 | University of Edinburgh | — |
| Unknown | Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders NCT04374721 | University of Roma La Sapienza | N/A |
| Unknown | Objective Markers and New Indicators in AI Disease (OMNI-AID Study) NCT03615859 | Imperial College London | — |
| Unknown | Hydrocortisone Vs Prednisolone in AI (HYPER-AID) NCT03608943 | Imperial College London | — |
| Completed | A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects NCT03311932 | Neurocrine UK Limited | Phase 1 |
| Completed | A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects NCT03343327 | Neurocrine UK Limited | Phase 1 |
| Completed | Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? NCT03368066 | University of Virginia | Phase 3 |
| Completed | Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study NCT03709381 | Nationwide Children's Hospital | EARLY_Phase 1 |
| Unknown | Optimising Steroid Replacement in Patients With Adrenal Insufficiency NCT03282487 | The Adelaide and Meath Hospital, incorporating The National Children's Hospital | Phase 4 |
| Completed | The Prevalence of Secondary Adrenal Insufficiency in Patients With Exacerbation of COPD in Glucocorticoid Trea NCT03140761 | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | — |
| Completed | Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral Administration NCT03178214 | Neurocrine UK Limited | Phase 1 |
| Completed | Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon NCT03074123 | Bnai Zion Medical Center | N/A |
| Completed | Prevalence of Adrenal Insufficiency in Kidney Transplanted Patients in Glucocorticoid Treatment NCT03136562 | Rigshospitalet, Denmark | — |
| Unknown | Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients NCT03083834 | Bnai Zion Medical Center | N/A |
| Completed | Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal Insuffici NCT03505775 | Wuerzburg University Hospital | N/A |
| Completed | Vaginal Prednisone Administration for Prevention of Adrenal Crisis NCT02689960 | Wuerzburg University Hospital | Phase 2 |
| Unknown | Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism NCT02282150 | Ulla Feldt-Rasmussen | Phase 4 |
| Completed | Dynamic Hormone Diagnostics in Endocrine Disease NCT02934399 | Haukeland University Hospital | — |
| Unknown | Adherence in Chronic Adrenal Insufficiency NCT03399383 | Wuerzburg University Hospital | N/A |
| Completed | THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortison NCT03013166 | Shire | — |
| Completed | Study to Investigate Adrenal Crisis (Six-year Follow-up) NCT03499990 | Wuerzburg University Hospital | — |
| Recruiting | Evaluation of Children With Endocrine and Metabolic-Related Conditions NCT02769975 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests NCT02818660 | Haukeland University Hospital | N/A |
| Completed | Extension Study for Patients Entered Into Study Infacort 003 NCT02733367 | Neurocrine UK Limited | Phase 3 |
| Unknown | Predisposing Factors for the Incidence of Adrenal Crisis NCT03410160 | Wuerzburg University Hospital | — |
| Completed | Management of Adrenal Emergency in Germany NCT03426332 | Wuerzburg University Hospital | — |
| Completed | Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency NCT03000231 | University of Chicago | — |
| Active Not Recruiting | Self-management in Patients With Adrenal Insufficiency. NCT06637722 | Region Stockholm | — |
| Unknown | Inhalation/Nasal Corticosteroids and Prevalence of Hypothalamic-pituitary-adrenal (HPA) Axis Suppression in Hu NCT02501486 | Radboud University Medical Center | N/A |
| Completed | Treatment of Adrenal Insufficiency in Children NCT02720952 | Neurocrine UK Limited | Phase 3 |
| Completed | National Education Programme for Patients With Chronic Adrenal Insufficiency NCT02694926 | Wuerzburg University Hospital | N/A |
| Completed | Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome NCT02368379 | Nationwide Children's Hospital | N/A |
| Completed | An Investigational Study of Hydrocortisone NCT01960530 | Neurocrine UK Limited | Phase 1 |
| Completed | Cardiovascular Status in Adrenal Insufficiency NCT03426319 | Wuerzburg University Hospital | — |
| Completed | Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia NCT01859312 | National Institutes of Health Clinical Center (CC) | Phase 2 |
| Completed | Physiological Response of Cortisol to Cardiac Catheterization NCT01822847 | Creighton University | — |
| Unknown | The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung NCT01703013 | Cantonal Hospital of St. Gallen | — |
| Completed | Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH NCT01735617 | Neurocrine UK Limited | Phase 2 |
| Completed | Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal NCT01652495 | Istituto Ortopedico Rizzoli | Phase 4 |
| Completed | Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) NCT01546922 | University Medical Center Groningen | Phase 4 |
| Completed | Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency NCT06260462 | University of Palermo | Phase 3 |
| Completed | Value of 25 mcg Cortrosyn Stimulation Test NCT01428336 | The Cleveland Clinic | N/A |
| Completed | Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I NCT01452893 | University of Wuerzburg | — |
| Completed | A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort Formulations NCT03051893 | Neurocrine UK Limited | Phase 1 |
| Completed | Cortisol Response to Moderate and Deep Sedation in Children NCT01265966 | Tripler Army Medical Center | — |
| Completed | Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury NCT01093261 | Nantes University Hospital | Phase 3 |
| Withdrawn | The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery NCT01045876 | St. Paul's Hospital, Canada | Phase 4 |
| Completed | An Open Label Study in Healthy Volunteers to Compare Chronocort® to Hydrocortisone NCT03019614 | Neurocrine UK Limited | Phase 1 |
| Completed | Pilot Study Assessing Oxidative Stress in Children NCT01052207 | Emory University | — |
| Unknown | Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARD NCT00773058 | Southeast University, China | Phase 4 |
| Completed | Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test NCT00851942 | Cardiff University | Phase 4 |
| Completed | Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With Shock NCT00974337 | All India Institute of Medical Sciences | — |
| Completed | Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency NCT00915343 | Shire | Phase 2 / Phase 3 |
| Withdrawn | Gene Polymorphisms Influencing Steroid Synthesis and Action NCT00485186 | University Hospital Schleswig-Holstein | — |
| Terminated | Does Inhaled Busedonide or Fluticasone Impair Adrenal Function? NCT00560625 | HaEmek Medical Center, Israel | — |
| Unknown | Adrenal Insufficiency in Critical Emergencies in Digestive Diseases NCT00562445 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency NCT01184209 | University of Wuerzburg | — |
| Withdrawn | Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe NCT00368381 | CAMC Health System | Phase 4 |
| Completed | Adrenal Function in Patients With Newly Diagnosed Lung Cancer NCT00364624 | Princess Margaret Hospital, Hong Kong | — |
| Completed | Evaluation of Etomidate on Adrenal Function in Trauma Patients NCT00462644 | University of Tennessee | N/A |
| Completed | Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis NCT00552487 | University of Wuerzburg | N/A |
| Completed | Adrenal Function in Critical Illness NCT00156767 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |
| Completed | Survey in Patients With Chronic Adrenal Insufficiency in Germany NCT00444119 | University of Wuerzburg | — |
| Completed | Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate NCT00575029 | University of Arkansas | N/A |
| Completed | Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency NCT00575341 | University Hospital Tuebingen | Phase 3 |
| Completed | Six Months DHEA Treatment in Female Adrenal Failure NCT00471900 | University of Aarhus | N/A |
| Terminated | Evaluation of Patients With Endocrine-Related Conditions NCT00005664 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |